Association between single nucleotide polymorphisms of the G-protein γ5 subunit and the risk of essential hypertension in the population of Poland

Hejduk, Paulina; Sakowicz, Agata; Mikołajczyk, Melania; Śliwińska, Agnieszka; Drzewoski, Józef; Pietrucha, Tadeusz

doi:10.20452/pamw.3207

Polish Archives of Internal Medicine

2015

DOI: 10.20452/pamw.3207

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Association between single nucleotide polymorphisms of the G-protein γ5 subunit and the risk of essential hypertension in the population of Poland

Paulina Hejduk¹,

Agata Sakowicz²,

Melania Mikołajczyk³

et al.

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“…In the long-term follow-up (mean, 4.7 years) of the HARVEST study participants, 825T allele of the C825T polymorphism in the GNB3 gene was associated with increased risk of hypertension and the necessity to start a pharmacological treatment. 7 In the current issue of the Polish Archives of Internal Medicine (Pol Arch Med Wewn), Hejduk et al 8 reported the results of their study on the association of 5 different SNPs with another G protein subunit gene, namely, the G protein γ5 subunit (GNG5) and the risk of essential hypertension. The authors recruited 536 patients with essential hypertension and 302 controls.…”

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Discovering the genetic basis of essential hypertension: hypes and hopes

Stolarz‐Skrzypek¹

2015

Polish Archives of Internal Medicine

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EDITORIAL Discovering the genetic basis of essential hypertension: hypes and hopes 891 the substitution of nucleotides, leading to the formation of 2 (or more) variants of a gene (alleles), with the prevalence within the general population of more than 1%.During the past 20 years, most researchers focused on the analysis of SNPs within the various genes encoding proteins involved in the regulation of BP (ie, candidate genes), as components of the renin-angiotensin-aldosterone system, natriuretic peptides, adrenergic receptors, or ion channels involved in renal reabsorption of sodium. 3 Association analyses, the most commonly used in the population studies, are designed to compare the distribution of alleles of the same gene in unrelated patients with hypertension and in normotensive individuals.It is anticipated that an allele of a particular gene is associated with the disease trait if it is observed with a much higher frequency in patients than in healthy subjects. The main disadvantage of this method is a high risk of falsepositive results (if the trait under investigation is relatively frequent in the studied population, the association might be detected for each allele common in this particular population). Thus, the important prespecified conditions for genetic studies include a proper selection of cases and controls, adequate number of participants, ethnically homogeneous groups, and, above all, rigorous phenotyping.G proteins represent the integral membrane cytoplasmic molecules acting as transmembrane biological signal amplifiers. They couple the receptors of hormones, biogenic amines, neurotransmitters with effectors acting inside cells, with the adenylate cyclase system, a metabolic pathway of inositol triphosphate or diacylglycerol or with ion channels. G proteins are built as heterotrimers and consist of 3 subunits: α, β, and γ. The main functional domains (associated with hydrolysis of guanine triphosphate) are in the α subunit. The β and γ subunits of G proteins anchor the membrane and are inolved in the interaction withIn the general population, blood pressure (BP) distribution is close to normal, which indicates a multifactorial etiology of essential hypertension, including both polygenetic and environmental factors. Tracing the natural history of hypertension is difficult because of the progress in the medical management of this condition and favorable changes to health care systems. As a result, a substantial number of hypertensive patients receive antihypertensive drugs that may affect changes in BP and hinder the analysis of genetic factors underlying hypertension. To perform genomic studies, first the extent of the genetic effect on the final phenotype of BP has to be elucidated.Data from family studies and twin studies have provided evidence for moderate heritability of BP values. The heritability of office BP was estimated at 15% to 40% for systolic BP and 15% to 30% for diastolic BP, while for ambulatory BP monitoring, the proportion of the share of the genetic effect was reported to be ...

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Discovering the genetic basis of essential hypertension: hypes and hopes

Stolarz‐Skrzypek¹

2015

Polish Archives of Internal Medicine

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Subtype-dependent regulation of Gβγ signalling

Tennakoon

Senarath

Kankanamge

et al. 2021

Cellular Signalling

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Association between single nucleotide polymorphisms of the G-protein γ5 subunit and the risk of essential hypertension in the population of Poland

Cited by 2 publications

References 2 publications

Discovering the genetic basis of essential hypertension: hypes and hopes

Discovering the genetic basis of essential hypertension: hypes and hopes

Subtype-dependent regulation of Gβγ signalling

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