Association between SIRT2 gene polymorphism and height in healthy, elderly Japanese subjects

Haketa, Akira; Soma, Masayoshi; Nakayama, Tomohiro; Kosuge, Kotoko; Aoi, Noriko; Hishiki, Mikano; Hatanaka, Yoshinari; Ueno, Takayoshi; Doba, Nobutaka; Hinohara, Shigeaki

doi:10.1016/j.trsl.2012.07.002

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…26 Studies in humans concluded that polymorphisms in SIRT2 affected height among elderly Japanese subjects and were associated with risk of Alzheimer's disease. 18,27 Since its development, T-ARMS-PCR method has become one of the most commonly used methods for SNP genotyping. 2,3 It is a signicant advantage over the commonly used PCR-RFLP method in which partial digests oen lead to inaccurate genotype inference.…”

Section: Discussionmentioning

confidence: 99%

“…12 Mechanistically, SIRT2 suppresses adipogenesis by deacetylating FOXO1 to promote FOXO1's binding to PPARg and subsequent repression on PPARg transcriptional activity. 17 Because of the important role of SIRT2 in metabolism and studies in humans have concluded that polymorphisms in SIRT2 affect height among elderly Japanese subjects, 18 here, we developed a sensitive, quick and low-cost T-ARMS-PCR assay to reliably detect bovine SIRT2 g.4140A > G polymorphism. We evaluated the accuracy of this method, and further investigated the genetic effects of this polymorphism on economic growth traits of Nanyang cattle.…”

Section: Introductionmentioning

confidence: 99%

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Tetra-primer ARMS-PCR is an efficient SNP genotyping method: An example from SIRT2

Sun

Jiang

et al. 2014

Anal. Methods

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tetra-primer ARMS-PCR is an efficient SNP genotyping method: An example from SIRT2

Sun

Jiang

et al. 2014

Anal. Methods

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“…The SIRT2 gene SNP (rs45592833G/T), which is located in the 3'-untranslated regions (3'UTR), is significantly associated with human longevity [41]. SIRT2 gene SNPs, rs2241703 in the 3’ untranslated region and rs11879029 in an intron, have been reported to be associated with height in a Japanese population [42]. The intronic SNP (rs10410544) in the SIRT2 gene significantly increases risk of Alzheimer's disease [43].…”

Section: Discussionmentioning

confidence: 99%

Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction

et al. 2017

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Coronary artery disease (CAD), including acute myocardial infarction (AMI) is the complication of atherosclerosis. Recently, genome-wide association studies have identified a large number of CAD-related genetic variants. However, only 10% of CAD cases could be explained. Low frequent and rare genetic variants have been recently proposed to be main causes for CAD. SIRT2 is a member of sirtuin family, NAD(+)-dependent class III deacetylases. SIRT2 is involved in genomic stability, metabolism, inflammation, oxidative stress and autophagy, as well as in platelet function. Thus, we hypothesized that genetic variants in SIRT2 gene may contribute to AMI. In this study, SIRT2 gene promoter was analyzed in large cohorts of AMI patients (n = 375) and ethnic-matched controls (n = 377). Three novel heterozygous DSVs (g.38900888_91delTAAA, g.38900270A>G and g.38899853C>T) were identified in three AMI patients, but in none of controls. These DSVs significantly altered the transcriptional activity of the SIRT2 gene promoter (P<0.05) in both HEK-293 and H9c2 cells. Five novel heterozygous DSVS (g.38900562C>T, g.38900413A>C, g.38900030G>A, g.38899925A>C and g.38899852C>T) were only found in controls, which did not significantly affected SIRT2 gene promoter activity (P>0.05). In addition, four novel heterozygous DSVs and five SNPs were found in both AMI patients and control with similar frequencies (P>0.05), two SNPs of which were examined and did not affect SIRT2 gene promoter activity (P>0.05). Taken together, the DSVs identified in AMI patients may change SIRT2 level by affecting the transcriptional activity of SIRT2 gene promoter, contributing to the AMI development as a rare risk factor.

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Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle

et al. 2018

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Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and SIRT3) play crucial roles in regulating lipid metabolism, cellular growth and metabolism, suggesting that they are potential candidate genes affecting body measurement traits in animals. Hence, the objective of this work aimed to detect novel insertions/deletions (indels) of SIRT1, SIRT2 and SIRT3 genes in 955 cattle belonging to five breeds, as well as to evaluate their effects on body measurement traits. Herein, the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc. (P < 0.05 or P < 0.01). Therefore, based on these findings, the two novel indel variants within bovine SIRT1 and SIRT2 genes could be considered as potential molecular markers for growth traits in cattle selection practices and breeding.

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Association between SIRT2 gene polymorphism and height in healthy, elderly Japanese subjects

Cited by 7 publications

References 12 publications

Tetra-primer ARMS-PCR is an efficient SNP genotyping method: An example from SIRT2

Tetra-primer ARMS-PCR is an efficient SNP genotyping method: An example from SIRT2

Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction

Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle

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