Association between skeletal muscle changes, anthropometric measurements, and clinical outcomes in critically ill trauma and surgical patients: A prospective observational study

Kangalgil, Melda; Ulusoy, Hülya; Turan, Sekine; Öncü, K.

doi:10.1002/ncp.10865

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…Our findings on skeletal muscle loss concurred with other studies in critically ill populations. On day 7 of ICU admission, RFCSA decreased by 16–23.2% from baseline 36,37 . In the present study, malnutrition and frailty status are associated with baseline RFCSA.…”

Section: Discussionsupporting

confidence: 50%

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Nutrition determinants of acute skeletal muscle loss in critically ill patients: A prospective observational cohort study

Kangalgil,

Küçük,

Ulusoy

et al. 2023

Nut in Clin Prac

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BackgroundSkeletal muscle loss is associated with adverse outcomes in critically ill patients and risk factors of acute skeletal muscle loss are not well described. This study aims to determine the factors associated with acute skeletal muscle loss in critically ill patients.MethodsThis prospective observational cohort study was conducted with patients who were expected to stay in the intensive care unit (ICU) for at least a week. Rectus femoris cross‐sectional area (RFCSA) measurements were performed within 48 h of ICU admission and on study day 7. The percentage change in RFCSA and variables associated with this change were evaluated by univariate and multivariate regression analysis.ResultsOver a 12‐month period, 518 patients were assessed for eligibility and 44 critically ill patients with a mean age of 59.3 ± 10.9 years were enrolled; 52.3% of them were female. There were significant reductions in RFCSA (16.8 ± 16.5%; P < 0.001). The mean amounts of protein and energy consumed compared with those prescribed were 67.0 ± 28.8% and 71.5 ± 38.3%, respectively. Multivariate regression analysis revealed that frailty was independently associated with acute skeletal muscle loss after adjusting for confounding factors in our cohort of patients.ConclusionFrailty status before ICU admission is associated with acute skeletal muscle loss and may be important for identifying critically ill patients at high risk of muscle wasting.

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Section: Discussionsupporting

confidence: 50%

“…On day 7 of ICU admission, RFCSA decreased by 16-23.2% from baseline. 36,37 In the present study, malnutrition and frailty status are associated with baseline RFCSA. This is not surprising, as reduced muscle mass is often common in malnutrition and frailty.…”

Section: Discussionmentioning

confidence: 50%

Nutrition determinants of acute skeletal muscle loss in critically ill patients: A prospective observational cohort study

Kangalgil,

Küçük,

Ulusoy

et al. 2023

Nut in Clin Prac

Self Cite

View full text Add to dashboard Cite

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Acute Skeletal Muscle Wasting is Associated with Prolonged Hospital Stay in Critical Illness with Brain Injury

Kangalgil,

Ulusoy,

Ayaz

2024

Neurocrit Care

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Background Acute muscle wasting is common in critically ill patients, and this can lead to unfavorable clinical outcomes. The aim of this study was to identify factors associated with muscle wasting and to investigate the association between skeletal muscle wasting and prolonged hospital stay in critically ill patients with acute brain injury. Methods This single-center prospective observational study was conducted in critically ill patients with acute brain injury who stayed in the intensive care unit for at least 1 week. The rectus femoris cross-sectional area was measured via ultrasound at baseline and a week after the first assessment. Univariate and multivariate logistic regression analyses were performed to identify factors that predicted prolonged hospital stay. Results A total of 86 patients were included in the study. Their mean age was 49.4 ± 16.9 years, 57% were male, and 46.5% had an admission diagnosis of subarachnoid hemorrhage. The percentage change in the rectus femoris cross-sectional area was 15.8% (95% confidence interval [CI] − 19.8% to − 12.0%; p < 0.001), and 57% of all patients had acute muscle wasting. According to the univariate analysis, there was a significant association between prolonged hospital stay and acute muscle wasting (odds ratio [OR] 3.677; 95% CI 1.487–9.043; p = 0.005), mechanical ventilation status (OR 3.600; 95% CI 1.455–8.904; p = 0.006), and Glasgow Coma Scale score (OR 0.888; 95% CI 0.808–0.976; p = 0.014) at intensive care unit admission. The multivariate analysis demonstrated that acute muscle wasting (OR 3.449; 95% CI 1.344–8.853; p = 0.010) was an independent risk factor for prolonged hospital stay. Conclusions There was considerable muscle wasting in critically ill patients with brain injuries over a 1-week period. Acute muscle wasting was associated with prolonged hospital stay in critically ill patients with acute brain injury.

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Body Composition Assessment in Critically Ill Adults – Where are We now?

Lambell,

Paris,

Gonzalez

et al. 2024

Critical Care Clinics

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Association between skeletal muscle changes, anthropometric measurements, and clinical outcomes in critically ill trauma and surgical patients: A prospective observational study

Cited by 6 publications

References 47 publications

Nutrition determinants of acute skeletal muscle loss in critically ill patients: A prospective observational cohort study

Nutrition determinants of acute skeletal muscle loss in critically ill patients: A prospective observational cohort study

Acute Skeletal Muscle Wasting is Associated with Prolonged Hospital Stay in Critical Illness with Brain Injury

Body Composition Assessment in Critically Ill Adults – Where are We now?

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