Association between SNPs in genes involved in folate metabolism and preterm birth risk

Wang, B J; Liu, M J; Wang, Yaqiang; Dai, Juncheng; Tao, Jun; Wang, S N; Zhong, Nanbert; Chen, Yue

doi:10.4238/2015.february.2.9

Cited by 24 publications

(14 citation statements)

References 25 publications

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“…MTHFR plays an important role in the conversion of 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate. Therefore, MTHFR can indirectly regulate the plasma Hcy level [24 ].The MTHFR gene C677T can cause the originally synthesized alanine to become valine, thereby reducing the enzyme activity, leading to the hindrance of Hcy metabolism, and which nally causing hyperhomocystinemia (Hhcy) [25].The maternal blood circulation is connected to the fetus through the placenta. Hhcy will also be manifested in the fetal blood circulation, which can cause fetal blood vessel development abnormalities, neural tube development abnormalities, and premature delivery.…”

Section: Discussionmentioning

confidence: 99%

Significant Interaction of MTHFR C677T, A1298C and MTRR A66G Polymorphisms on the Risk of Low Birth Weight Infants

Sun

Liu

Guo

et al. 2021

Preprint

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Background: To explore the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C, Methionine Synthase Reductase (MTRR) gene A66G and the recurrence of low birth weight(LBW) in offspring. Methods: Allele-specific polymerase chain reaction (ASPCR) assay combined with TaqMan probe technique were used to detect the mother’s MTHFR and MTRR genotypes respectively. And unconditional logistic regression analysis was used to evaluate the associations of MTHFR and MTRR polymorphisms, and gene-gene interaction with low birth weight.Results: MTHFR 677TT and 1298CC were independently associated with a higher risk of LBW (OR:2.22, 95%CI:1.14-4.34 and OR:2.82, 95% CI:1.15-6.87,respectively). The MTRR A66G polymorphism was associated with an significant association of LBW when combined with the MTHFR 677TT genotype, although there was no association found between LBW and MTRR A66G alone.Moreover, two or more risk genotypes carriers showed higher odds of LBW than null risk genotype one.Conclusion: Maternal MTHFR gene 677TT, 1298CC can increase the risk of LBW in the offspring.The MTRR A66G polymorphism was not associated with LBW alone. But it may exacerbate the effect of the MTHFR C677T variant.

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Section: Discussionmentioning

confidence: 99%

Significant Interaction of MTHFR C677T, A1298C and MTRR A66G Polymorphisms on the Risk of Low Birth Weight Infants

Sun

Liu

Guo

et al. 2021

Preprint

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“…The research shows that genotypes of complex mutations may increase the risk of preterm delivery. The study lists: MTHFD-G1958A, MTR-A2756G, RFC1-G80A, MTHFD-G1958A, MTR-A2756G and CBS-C699T [12] However, the presence of SNP in candidate genes does not always have a negative effect on the length of pregnancy. In studies conducted in 2013 by Dr. Wei Wu, the reverse conclusions were drawn.…”

Section: Discussionmentioning

confidence: 99%

The role of prostaglandins and polymorphisms of A2 phospholipase genes in the occurrence of early uterine contractions during pregnancy

Borowiec

Hadada

Kosińska

2018

Medical Journal of Cell Biology

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This study focused on the role of polymorphisms in prostaglandin expression regulating genes in the occurrence of early uterine contractions during pregnancy. The analyzed genes were: PLA2G4C, encoding calcium independent phospholipase A2, and PLA2G4C, encoding IVD phospholipase A2. It was examined if known reference polymorphisms in these genes (rs1366442, [A/C/T] for PLA2G4C; and rs4924618, [A/T] for PLA2G4D), have any influence on preterm birth. Additionally, other biological, genetic and socio-economic factors were taken into account and analyzed, based on their role in induction of early resolve of pregnancy in the study group. Blood samples were taken from 20 patients. 15 of them gave birth preterm, 5 gave birth at the predicted date of pregnancy resolve. DNA was isolated from the samples, and subjected to PCR, with obtained amplified samples separated using electrophoresis on 1,5% agarose gel. Resulting material was subjected to high-throughput sequencing. Statistical analysis was performed using Statistica 13 software. Analyses have shown that the discussed biological, genetic and societal-economic factors have statistically significant influence on preterm birth. Sequencing results presented the suspected presence of the analyzed SNPs in most women from the studied groups, while not showing their presence in any of the controls. The biological, genetic, and socio-economic factors analyzed have a significant influence on pre-term birth. Presence of SNPs in PLA2G4C and PLA2G4D genes may increase the risk of early resolve of pregnancy. However, as the control and study groups were relatively small, it is suggested to repeat the studies on bigger samples to validate the results.

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“…The second most common complicated and multifactorial congenital malformation of central nervous system is Neural Tube Defects (NTD) [25,28]. According to 2012 WHO report, three lakh babies were affected per year worldwide by NTD.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of MTR and MTRR gene polymorphisms in healthy mothers from Eastern part of India

Sadhukhan

Paul

Bankura

et al. 2018

IJRDPL

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Available online on:15.01.2018@http://ijrdpl.com http://dx.doi.org/10.21276/IJRDPL. 2278-0238.2018.7(1).2896-2900 ABSTRACT:The polymorphic variation of MTR and MTRR genes can influence the folate metabolism and homeocysteine remethylation processes and consequently has strong impact on Neural Tube Defects (NTD). The SNP of MTR and MTRR genes has been reported in some populations, but in the Indian population has never been explored. This study is focused on the frequency distributions of rs1805087 (D919G/A2756G) and rs1801394 (I22M/A66G) of these genes in the West Bengal population, India for the first time. The G allele frequencies of rs1085087 and rs1801394 were 8% and 47% respectively. The G allele frequency of MTR rs1085087 in Indian population is less than the other major population; such as, in European (17%), American (18%), African (28%) and South Asian (32%) population. The G allele frequency of MTRR rs1801394 is quite like the European and south Asian population (G=52%) but greatly differs from African (25%), East Asian (26%) and mixed American (28%) population. This observation might help us to understand pattern of genetic alteration and development of single screening protocol for early detection and better prognosis in future.

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Association between SNPs in genes involved in folate metabolism and preterm birth risk

Cited by 24 publications

References 25 publications

Significant Interaction of MTHFR C677T, A1298C and MTRR A66G Polymorphisms on the Risk of Low Birth Weight Infants

Significant Interaction of MTHFR C677T, A1298C and MTRR A66G Polymorphisms on the Risk of Low Birth Weight Infants

The role of prostaglandins and polymorphisms of A2 phospholipase genes in the occurrence of early uterine contractions during pregnancy

Genetic analysis of MTR and MTRR gene polymorphisms in healthy mothers from Eastern part of India

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