Association between SNPs within candidate genes and compounds related to boar taint and reproduction

Moe, Maren; Lien, Sigbjørn; Aasmundstad, T.; Meuwissen, Theo H. E.; Hansen, Marianne Helén Selander; Berthou, Christian; Grindflek, Eli

doi:10.1186/1471-2156-10-32

Cited by 48 publications

(53 citation statements)

References 70 publications

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“…Although lack of sufficient phenotypic data for these traits prevent considering this idea in breeding experiments, direct selection of genes or markers which carry favourable alleles for two traits in small selection groups could be practical in dairy cattle breeding programmes. Such ideas for animal genotyping is introduced by Moe et al (2009), which were based on selection against defective sires when considering fertility.…”

Section: Discussionmentioning

confidence: 99%

Case–control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle

et al. 2015

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Mastitis is a major source of economic loss in dairy herds. The objective of this research was to evaluate the association between genotypes within SLC11A1 and CXCR1 candidate genes and clinical mastitis in Holstein dairy cattle using the selective genotyping method. The data set contained clinical mastitis records of 3,823 Holstein cows from two Holstein dairy herds located in two different regions in Iran. Data included the number of cases of clinical mastitis per lactation. Selective genotyping was based on extreme values for clinical mastitis residuals (CMR) from mixed model analyses. Two extreme groups consisting of 135 cows were formed (as cases and controls), and genotyped for the two candidate genes, namely, SLC11A1 and CXCR1, using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), respectively. Associations between single nucleotide polymorphism (SNP) genotypes with CMR and breeding values for milk and protein yield were carried out by applying logistic regression analyses, i.e. estimating the probability of the heterogeneous genotype in the dependency of values for CMR and breeding values (BVs). The sequencing results revealed a novel mutation in 1139 bp of exon 11 of the SLC11A1 gene and this SNP had a significant association with CMR (P < 0.05). PCR-RFLP analysis leads to three banding patterns for CXCR1c.735C>G and these genotypes had significant relationships with CMR. Overall, the results showed that SLC11A1 and CXCR1 are valuable candidate genes for the improvement of mastitis resistance as well as production traits in dairy cattle populations.

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Section: Discussionmentioning

confidence: 99%

Case–control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle

et al. 2015

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“…In a study with Nellore heifers, Andréa et al (2007) did not find a significant association between CYP21 gene polymorphisms with weight at 450 days and between prolactin gene polymorphisms with age at first calving. In pigs, Moe et al (2009) did not find a significant association between SNPs at the CYP21 and the estimated steroid levels of these animals.…”

Section: Resultsmentioning

confidence: 62%

Association between IGF2 and CYP21 gene polymorphisms and characteristics of economic interest in Nellore cattle

Martins-da-Silva¹,

Rios²,

Ramos³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. We analyzed two single nucleotide polymorphisms (SNPs) of the IGF2 and CYP21 genes in Nellore cattle participating in the Brazilian Animal Breeding Program. The SNPs were found in exon 6 of the IGF2 (insulin-like growth factor 2) gene (RFLP/MboII) as well as in the promoter region of the CYP21 (steroid 21-hydroxylase) gene (RFLP/HpaII) of these animals. The TC heterozygotes were significantly more frequent than CC and TT homozygotes in the RFLP/ MboII polymorphism. The T allele was significantly more frequent than the C allele in RFLP/HpaII polymorphism. This population was found IGF2 and CYP21 gene polymorphisms in Nellore cattle to be in Hardy-Weinberg equilibrium for these SNPs. Association of these polymorphisms with expected progeny differences of reproductive and productive traits was investigated, but proved to be significant only for DP550 (expected progeny differenced for weight at 365 days -IGF2 -RFLP/MboII) and DP450 (expected progeny differenced for weight at 450 days -CYP21 -RFLP/HpaII). This is the first study on the occurrence of these two polymorphisms in this Zebu breed of cattle. A total of 147 Nellore animals participating in the Breeding Program of the Nellore Breed (PMGRN) under the management of the National Association of Breeders and Researchers (ANCP) in the city of Ribeirão Preto were analyzed.

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“…Another interesting candidate on our list is CYP2E1, which is involved in steroid metabolism (Ball et al 1990). Polymorphisms of porcine CYP2E1 show an effect on skatole level, a compound causing boar taint (Moe et al 2009). The question of whether CYP2E1 polymorphisms show pleiotropic effects also on cortisol levels merits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress

Muráni¹,

Ponsuksili²,

D’Eath³

et al. 2011

Journal of Molecular Endocrinology

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To gain insight into the adrenal stress response, we analysed differential mRNA expression of genes associated with psychosocial stress in the pig (Sus scrofa domestica). Various levels of psychosocial stress were induced by mixing groups of unfamiliar pigs with different aggressiveness. We selected two experimental groups for comparison, each comprising eight animals, which differed significantly in aggressive behaviour and plasma cortisol levels. To identify differentially expressed genes, we compared the adrenal transcriptome of these two groups of pigs, using the Affymetrix GeneChip porcine Genome Array. Bioinformatic analysis revealed that psychosocial stress induced upregulation of transcripts enriched for functions associated with cholesterol accumulation and downregulation of transcripts enriched for functions associated with cell growth and death. These responses are similar to those induced by ACTH stimulation. Nevertheless, the majority of the differentially expressed genes were so far not described as ACTH responsive. Some, such as GAL and GALP, may have responded to sympathoadrenal stimulation. Several of the differentially expressed transcripts, such as AGT, are associated with processes modulating steroidogenic response of adrenocortical cells to ACTH. One of the most significant findings was upregulation of LOC100039095, comprising a precursor of the microRNA miR-202, pointing to a previously unrecognised layer of regulation of adrenal steroidogenesis by microRNA. Our study, performed under entirely physiological conditions, complements previous studies focusing either on a single adrenal tissue and/or on a single stimulus, and contributes to understanding of the fine-tuning of adrenal stress response.

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Association between SNPs within candidate genes and compounds related to boar taint and reproduction

Cited by 48 publications

References 70 publications

Case–control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle

Case–control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle

Association between IGF2 and CYP21 gene polymorphisms and characteristics of economic interest in Nellore cattle

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress

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