Association Between Sputum Atypia and Lung Cancer Risk in an Occupational Cohort in Yunnan, China

Fan, Yaguang; Hu, Ping; Jiang, Yong; Chang, Runsheng; Yao, Shuntian; Wang, Ke; He, Jie; Prorok, Philip C.; Qiao, You‐Lin

doi:10.1378/chest.08-1469

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…Since 1986, the NCI/NIH has worked with the Cancer Institute, Chinese Academy of Medical Sciences (CICAMS), and the Labor Protection Institute of Yunnan Tin Corporation (YTC) to conduct a number of different scientific studies among tin miners at the YTC, located in Gejiu, Yunnan Province, China, the largest tin industry site in Asia. Dr. Ping Hu (National Cancer Institute, National Institutes of Health) indicated that several studies have been initiated to identify early biomarkers and evaluate etiologic factors in tin miners in China (1).…”

Section: Introductionmentioning

confidence: 99%

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Bode¹,

Cao²,

Dong³

2010

Cancer Prevention Research

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Cancer is one of the major physical, social, and economic burdens and public health threats worldwide. Citizens everywhere face the challenge of dealing with the costs and devastation of this dreadful disease regardless of country of residence. In October 2009, a joint China-U.S. forum focusing on cancer prevention was held in Changsha, China. The goal of this timely joint conference was to provide a forum for the exchange of the most recent and relevant information on cancer control, translational cancer prevention research, and clinical trials in China and the United States. The scientifically driven symposium comprised didactic sessions that included discussions focused on identifying and validating effective chemopreventive agents and their molecular and cellular targets. A major highlight of the meeting was the participation of Chinese and American experts from Xiangya Medical School, Central South University and the Center for Health Policy and Management (China), and the National Institutes of Health (NIH, United States), who provided a unique insight into each country's public efforts and progress in cancer prevention. Participants clearly agreed that our current understanding of the many factors influencing cancer causation indicates that as much as two thirds or more of human cancers can be prevented. This perspective presents an overview of the progress being made in cancer prevention in China and the United States. Cancer Prev Res; 3(12); 1630-7. Ó2010 AACR.

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Section: Introductionmentioning

confidence: 99%

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Bode¹,

Cao²,

Dong³

2010

Cancer Prevention Research

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“…The intra-epithelial neoplastic lesions may be asymptomatic and can only be identified by direct visualization at bronchoscopy. Screening test using sputum cytology has been used with limited success [4]. Evaluation of low dose spiral computer tomography (CT) scan as screening tool for lung cancer is being studied [5], and its limitations include high costs, need for repeated scanning and requirement of histological confirmation.…”

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confidence: 99%

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Gao

Asmitanand²,

Ren³

et al. 2012

neo

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White light bronchoscopy [WLB] has been used for identification and localization of intra-epithelial pre-neoplastic and neoplastic lesions within the bronchus. Aim of the study was to evaluate the uses of WLB to detect and localize the precancerous and cancerous lesions, and in addition to analyze morphologic presentation, and association to histological type and the variation between genders.A total of 4983 patients were examined by WLB from 2004 to 2009 in a local tertiary teaching hospital. The following parameters were collected: morphological presentation, biopsy sites, histology. The patients' records of age, sex, smoking status, blood-gas, X-RAY/CT, CBC, ECG, PT, and APTT were obtained for analysis. Differences between the patients groups were analyzed using Chi square test.1489 patients who had hyperplasia or neoplasic lesions were further confirmed as having lung cancer pathologically. Lung cancer was more commonly found in the right lung (51.58% vs 42.82%). The upper lobe was more frequently found to have lesions (44.17% vs 22.42%) than the lower lobe. Male patients with squamous cell carcinoma showed more commonly upper lobe involvement, while left main bronchus was more commonly involved in female patients. Adenocarcinoma was mostly involved in lesions of the upper lobe. Proliferative type was found in 80.15% of squamous cell carcinoma cases and in 76.16 % of small cell carcinoma cases.Fiberoptic bronchoscopy is an effective method for the detection of preinvasive neoplasic lesions. The morphological presentation is associated to histological type. There is variation in presentation and histology of cancerous lung lesion between the genders.

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“…Cytologic atypia in sputum was an independent risk factor for lung cancer. The authors concluded that sputum cytologic examination combined with other screening approaches could play an important role in the early detection of lung cancer or in the selection of the optimal target population for more intensive lung cancer screening in this high-risk occupational cohort (20).…”

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confidence: 99%

“…With a specificity of 85%, this study's FISH markers in sputum specimens collected within 18 months of clinical diagnosis exceeded the specificity of any other prospective lung cancer screening sputum test reported to date. Current research is comparing this original probe set to others based on chromosomal regions commonly amplified in lung cancer (20,24,26). In future studies, evaluation of additional chromosomal abnormalities, application of techniques for epithelial cell enrichment, and new methods for automated sputum assessment could allow for better scrutiny of abnormal cells and facilitate translation into clinical settings.…”

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confidence: 99%

“…In future studies, evaluation of additional chromosomal abnormalities, application of techniques for epithelial cell enrichment, and new methods for automated sputum assessment could allow for better scrutiny of abnormal cells and facilitate translation into clinical settings. These are additional features that may all contribute to augmenting the performance of this assay (20,24,26,31).…”

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confidence: 99%

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Lung Cancer Biomarkers: FISHing in the Sputum for Risk Assessment and Early Detection

Gomperts

Spira

Elashoff

et al. 2010

Cancer Prevention Research

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This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) discusses the role of sputum-based biomarkers in the risk assessment and early detection of lung cancer. The importance of the detection of sputum epithelial chromosomal aneusomy by fluorescence in situ hybridization (FISH) as a potential risk or early-detection biomarker is discussed in the context of other biomarkers and models in lung carcinogenesis. The presently reported findings on FISH in sputum cells are an important contribution worthy of further investigation in defined clinical settings. Cancer Prev Res; 3(4); 420-3. ©2010 AACR.

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Association Between Sputum Atypia and Lung Cancer Risk in an Occupational Cohort in Yunnan, China

Cited by 18 publications

References 21 publications

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Lung Cancer Biomarkers: FISHing in the Sputum for Risk Assessment and Early Detection

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Association Between Sputum Atypia and Lung Cancer Risk in an Occupational Cohort in Yunnan, China

Cited by 18 publications

References 21 publications

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Lung Cancer Biomarkers: FISHing in the Sputum for Risk Assessment and Early Detection

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Fiber-optic bronchoscope and detection of lung cancer: A five year study