Association between SSNHL and Thyroid Diseases

Kim, So Young; Song, Young Shin; Wee, Jee Hye; Min, Chanyang; Yoo, Dae Myoung; Choi, Hyo Geun

doi:10.3390/ijerph17228419

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Additionally, we analyzed other subgroups. We classified participants by obesity status (BMI < 23 or BMI ≥ 23), smoking status (nonsmoker or smoker), alcohol consumption (<1 time a week or ≥1 time a week), blood pressure (normal or hypertension (systolic blood pressure ≥ 120 mmHg or diastolic blood pressure ≥ 80 mmHg)), fasting blood glucose (normal (<100 mg/dL) or hyperglycemia (≥100 mg/dL)), and total cholesterol (normal (<200 mg/dL) or dyslipidemia (≥200 mg/dL)) [22][23][24]. An unconditional logistic regression model for osteoporosis associated with Hb level was constructed to analyze the ORs with 95% CIs.…”

Section: Statistical Analysesmentioning

confidence: 99%

Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort

Kim

Yoo

Min

et al. 2021

IJERPH

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An association between anemia and an increased risk of osteoporosis has been suggested. The goal of this study was to estimate the association of hemoglobin (Hb) level with osteoporosis. A total of 69,760 osteoporosis patients aged ≥ 40 years old from the Korean National Health Insurance Service Health Screening Cohort were enrolled. From an identical cohort database, 69,760 comparison participants were randomly selected. Hb levels before the onset of osteoporosis were evaluated. The association of Hb level with osteoporosis was analyzed using a conditional logistic regression model adjusted for obesity, smoking status, alcohol consumption, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, and the Charlson comorbidity index score. Fifteen percent of the osteoporosis group and 14.17% of the comparison group had anemia. The Hb level was associated with 0.98-fold lower odds for osteoporosis (95% confidence intervals = 0.97–0.99, p < 0.001). A low Hb level was associated with a high risk of osteoporosis in the adult population. There was a consistent association between a low Hb level and osteoporosis in patients with comorbidities.

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Section: Statistical Analysesmentioning

confidence: 99%

Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort

Kim

Yoo

Min

et al. 2021

IJERPH

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“…Recently, many studies have found that hematological indices, such as routine blood parameters, serum lipid level, and coagulation function, predicted a favorable prognosis in patients with SSNHL [24][25][26] . Kim et al 27 studied a large, representative population cohort found that SSNHL patients are more likely to have goiter and hypothyroidism than normal people. In addition, a large case-control study in Taiwan reported that pre-existing hypothyroidism and hyperthyroidism are associated with SSNHL susceptibility 28 .…”

Section: Discussionmentioning

confidence: 99%

Thyroid-related Hormone Levels in Clinical Patients with Moderately Severe-to-Profound Sudden Sensorineural Hearing Loss: A Prospective Study

Zheng¹,

Shen²,

Liang³

et al. 2021

Preprint

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Background and PurposeSSNHL is a common otology emergency, that may lead to hearing loss and impact quality of life. This study aims to investigate the association of thyroid-related hormone levels with moderately severe-to-profound sudden sensorineural hearing loss (SSNHL) that may contribute to treatment optimization.MethodsThe study included 70 patients with moderately severe-to-profound SSNHL and 100 age- and sex-matched healthy controls. Peripheral venous blood samples were taken from the participants, and their thyroid-related hormone levels were measured at admission and one week after treatment.ResultsThyroid-related hormone levels of total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) (all P < 0.05) were found to be at significantly lower levels in moderately severe-to-profound SSNHL patients to that of the control group. The increases of TT3, TT4, FT3, and TSH levels were significantly higher in the effective group than that in the ineffective group (all P < 0.05). Through receiver operating characteristic curve analyses, areas under the curve were 0.737, 0.636, 0.837, 0.458, and 0.903 for TT3, TT4, FT3, FT4, and TSH, respectively. Linear correlation analysis revealed that TSH level (R = 0.707, P < 0.05) elevation after treatment successfully predicted a favorable outcome of hearing recovery. Logistic regression analyses suggest low FT3 and TSH levels to be independent occurrence predictors while the increase of TSH level may be an independent favorable outcome predictor.ConclusionsThe results suggest low FT3 and TSH levels are risk factors for moderately severe-to-profound SSNHL. By discovering the positive association between TSH elevation and hearing recovery, along with the potential novel predictors of FT3 and TSH, our study may contribute valuable insights to the study and treatment of moderately severe-to-profound SSNHL.Trial RegistrationChinese Clinical Trial Registry; ChiCTR1800017072. Registered 10 July 2017, http://www.chictr.org.cn/showproj.aspx?proj=29023

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“…The demographic and clinical data before the onset of treatments were collected, including age, gender, body mass index (BMI, weight in kilograms divided by the square of height in meters), side, accompanied symptoms and audiogram type. The audiogram was divided into ascending, descending, flat and profound, as previously described ( Xie et al, 2020a ; Kim et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

Wang

Gao

Jiang

2022

Front. Mol. Biosci.

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Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments.

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Association between SSNHL and Thyroid Diseases

Cited by 8 publications

References 39 publications

Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort

Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort

Thyroid-related Hormone Levels in Clinical Patients with Moderately Severe-to-Profound Sudden Sensorineural Hearing Loss: A Prospective Study

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

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