Association between statin-associated myopathy and skeletal muscle damage

Mohaupt, Markus; Karas, Richard H.; Babiychuk, Eduard B.; Sánchez-Freire, Verónica; Monastyrskaya, Katia; Iyer, Lakshmanan K.; Hoppeler, Hans; Breil, Fabio; Draeger, Annette

doi:10.1503/cmaj.081785

Cited by 142 publications

(101 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In spite of all the degenerative findings encountered in the present study and in other studies, some researches considered atorvastatin and the other statins safe to use even in high doses [42] and consider statins the most effective prescribed drugs for lowering serum cholesterol [43] not only by inhibiting cholesterol synthesis, but also through other mechanisms.…”

Section: The Morphometric Resultscontrasting

confidence: 84%

Structural Changes in the Skeletal Muscle Fiber of Adult Male Albino Rat Following Atorvastatin Treatment; the Possible Mechanisms of Atorvastatin Induced Myotoxicity

Mokhmer¹,

Saber²,

Hamouda³

et al. 2017

J Cytol Histol

View full text Add to dashboard Cite

show abstract

Section: The Morphometric Resultscontrasting

confidence: 84%

Structural Changes in the Skeletal Muscle Fiber of Adult Male Albino Rat Following Atorvastatin Treatment; the Possible Mechanisms of Atorvastatin Induced Myotoxicity

Mokhmer¹,

Saber²,

Hamouda³

et al. 2017

J Cytol Histol

View full text Add to dashboard Cite

show abstract

“…A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 regulation of ryanodine receptor, suggestive of intracellular calcium increase, was found in muscle biopsies of statin treated patients showing evident structural damage [16]. Our previous studies have demonstrated that statin and fibrate affect skeletal muscle function also by modifying calcium homeostasis and resting chloride conductance (gCl).…”

Section: Page 4 Of 47mentioning

confidence: 98%

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

Camerino

Pellegrino

Brocca

et al. 2011

Biochemical Pharmacology

View full text Add to dashboard Cite

Statins and fibrates can cause myopathy. To further understand the causes of the damage we performed a proteome analysis in fast-twitch skeletal muscle of rats chronically treated with different hypolipidemic drugs. The proteomic maps were obtained from extensor digitorum longus (EDL) muscles of rats treated for 2-months with 10mg/kg atorvastatin, 20mg/kg fluvastatin, 60mg/kg fenofibrate and control rats. The proteins differentially expressed were identified by mass spectrometry and further analysed by immunoblot analysis. We found a significant modification in 40 out of 417 total spots analysed in atorvastatin treated rats, 15 out of 436 total spots in fluvastatin treated rats and 21 out of 439 total spots in fenofibrate treated rats in comparison to controls. All treatments induced a general tendency to a down-regulation of protein expression; in particular, atorvastatin affected the protein pattern more extensively with respect to the other treatments.Energy production systems, both oxidative and glycolytic enzymes and creatine kinase, were downregulated following atorvastatin administration, whereas fenofibrate determined mostly alterations in glycolytic enzymes and creatine kinase, oxidative enzymes being relatively spared. Additionally, all treatments resulted in some modifications of proteins involved in cellular defenses against oxidative stress, such as heat shock proteins, and of myofibrillar proteins. These results were confirmed by immunoblot analysis. In conclusions, the proteomic analysis showed that either statin or fibrate administration can modify the expression of proteins essential for skeletal muscle function suggesting potential mechanisms for statin myopathy.

show abstract

“…[1][2][3][4][5][6] Vitamin D deficiency is common in the U.S. and worldwide [7][8][9] and may cause muscle dysfunction. [10][11][12] Dietary vitamin D 3 or vitamin D 3 formed in the skin after sunlight exposure, is rapidly converted to 25-hydroxyvitamin D 3 [25(OH) D 3 ] in the liver.…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias

Linde

Peng

Desai

et al. 2010

Dermato-Endocrinology

View full text Add to dashboard Cite

Association between statin-associated myopathy and skeletal muscle damage

Cited by 142 publications

References 25 publications

Structural Changes in the Skeletal Muscle Fiber of Adult Male Albino Rat Following Atorvastatin Treatment; the Possible Mechanisms of Atorvastatin Induced Myotoxicity

Structural Changes in the Skeletal Muscle Fiber of Adult Male Albino Rat Following Atorvastatin Treatment; the Possible Mechanisms of Atorvastatin Induced Myotoxicity

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias

Contact Info

Product

Resources

About