Association between stress and glycemic control in adults with type 1 (insulin-dependent) diabetes.

Lloyd, Cathy E.; Dyer, Philip; Lancashire, Robert J.; Harris, Thurl E.; Daniels, John; Barnett, Anthony

doi:10.2337/diacare.22.8.1278

Cited by 95 publications

(66 citation statements)

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“…However, it is important keep in mind that the differences in life events between diabetic patients and control subjects in the current study could be caused by events of independent illness or manifestations of early stages of diabetes. The institution of insulin treatment leading to improvement of glycemic control after the diagnosis may have induced an independent lifestyle in the diabetic patients (19,20), retrospectively explaining the differences found in social behavior between our diabetic patients and control subjects. Moreover, in keeping with our findings, major life stress and psychiatric disorders are not always found before the onset of childhood diabetes (21).…”

Section: Life Eventsmentioning

confidence: 85%

Family Characteristics and Life Events Before the Onset of Autoimmune Type 1 Diabetes in Young Adults

et al. 2001

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LARS WIBELL, MD, PHD 10OBJECTIVE -To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults.RESEARCH DESIGN AND METHODS -This investigation was based on a nationwide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age-and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis.RESULTS -The rate of response was 82% for the diabetic patients and 65% for the control subjects. Questionnaires from 349 diabetic patients and 979 control subjects were considered. Diabetes in relatives was more frequent in the patients (odds ratio [OR]2.6) who were born in Sweden and whose mothers were of Swedish origin. No major stress factors were detected in the diabetic patients; however, in comparison with the control subjects, the diabetic patients had experienced fewer conflicts with their parents and had less often broken contacts with friends.CONCLUSIONS -Young adults with recent-onset type 1 diabetes were more exposed to heredity for diabetes, but no major prediabetic stress factors were detected. Our study does not directly support the concept that psychosocial stressful life events are involved in the development of autoimmune type 1 diabetes in young adults.

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Section: Life Eventsmentioning

confidence: 85%

Family Characteristics and Life Events Before the Onset of Autoimmune Type 1 Diabetes in Young Adults

et al. 2001

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“…Stress negatively affects either people with diabetes [24,29,35,36] or without [17][18][19][20][21][22]. Positive life events were associated with improved glycemic control; on the other hand, recent severe stressors were associated with poorer glycemic control [35].…”

Section: Discussionmentioning

confidence: 99%

Lessons Learnt from Influences of the Marmara Earthquake on Glycemic Control and Quality of Life in People with Type 1 Diabetes

Şengül¹,

Özer

Salman

et al. 2004

Endocr J

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Abstract. To examine the short-and long-term influences of the Marmara earthquake, which occurred on August 17, 1999 in Turkey, on glycemic control and quality of life (QOL), HbA 1c, insulin requirement and QOL of 88 people with type 1 diabetes living in the quake zone were evaluated one year before (PreE), 3 months after (PostE) and one year after (FE) the earthquake. HbA 1c levels and daily insulin requirements increased significantly at PostE (HbA 1c from 7.4 ± 1.3% to 8.5 ± 1.8%, p<0.05; insulin from 0.58 ± 0.2 IU/kg/day to 0.77 ± 0.2 IU/kg/day, p<0.05). Mean total QOL scores at PostE were significantly lower than the scores obtained at PreE (62.7 ± 17.3 vs 74.2 ± 13.4, p<0.001). There were no significant differences between HbA 1c levels and total QOL scores at PreE and FE. People with type 1 diabetes living in the same house after the earthquake and not having enough food supply were reported to have lower QOL than people moving to another house and having enough food supply after the earthquake (p = 0.014, p<0.0001, respectively). The Marmara Earthquake had a negative impact on the glycemic control and QOL of the subjects with type 1 diabetes for the short term but prequake scores might be achieved after a long period.

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“…Whereas some research has demonstrated that life challenges are associated with higher levels of urinary epinephrine or norepinephrine (22,24), others found no such relationship (21,25). Other evidence suggests that life challenges may contribute to higher levels of interleukin-6 (IL-6) (26,27), dehydroepiandrosterone sulfate (DHEAS) (28), blood pressure (29 -31), cholesterol (32)(33)(34), triglycerides (31), and glycosylated hemoglobin (35)(36)(37).…”

Section: Link Between Stressful Life Events and Physiologymentioning

confidence: 99%

Do Chronic Stressors Lead to Physiological Dysregulation? Testing the Theory of Allostatic Load

Glei

Goldman²,

Chuang³

et al. 2007

Psychosomatic Medicine

124

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Objectives: To explore three questions: 1) Do chronic stressors predict physiological dysregulation? 2) Is that relationship moderated by characteristics of the individual and his or her social environment? and 3) Do perceived levels of stress mediate the relationship between stressors and dysregulation? Methods: Data come from a nationally representative, longitudinal study of older Taiwanese (n ϭ 916). Regression models are used to examine the relationship between the number of life challenges (i.e., stressors) during 1996 to 2000 and physiological dysregulation (in 2000) based on 16 biomarkers that reflect neuroendocrine function, immune system, cardiovascular function, and metabolic pathways. We include interaction terms to test whether psychosocial vulnerability moderates the impact of stressors. Additional models evaluate the mediating effects of perceived stress. Results: We find a positive association between the number of stressors and physiological dysregulation. The results indicate that this relationship is stronger for persons with greater psychosocial vulnerability, but even so, the magnitude of the effect remains modest. We find some evidence that the level of perceived stress mediates the relationship between chronic stressors and physiological dysregulation. Conclusions: Our results provide some support for the theory of allostatic load, although the relationship between life challenges and physiological dysregulation is weak. The evidence also supports the stress-buffering hypothesis: the combination of low social position, weak social networks, and poor coping ability is associated with greater physiological consequences of life challenges.

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Association between stress and glycemic control in adults with type 1 (insulin-dependent) diabetes.

Cited by 95 publications

References 1 publication

Family Characteristics and Life Events Before the Onset of Autoimmune Type 1 Diabetes in Young Adults

Family Characteristics and Life Events Before the Onset of Autoimmune Type 1 Diabetes in Young Adults

Lessons Learnt from Influences of the Marmara Earthquake on Glycemic Control and Quality of Life in People with Type 1 Diabetes

Do Chronic Stressors Lead to Physiological Dysregulation? Testing the Theory of Allostatic Load

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