Association between Stress and the HPA Axis in the Atopic Dermatitis

Lin, Ting Wei; Zhong, Lily; Santiago, Juan Luis

doi:10.3390/ijms18102131

Cited by 82 publications

(93 citation statements)

References 124 publications

(199 reference statements)

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“…Recently, a hypothesis of the gut-brain-skin axis is being developed [68]. It has been proved that various skin disorders (urticarial, atopic dermatitis, psoriasis) have a strong correlation with the emotional status of the patient [69,70,71,72]. It has been shown that there is a negative influence on the immune system causing a greater risk of infections in patients subjected to mild to severe chronic stress [72].…”

Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world's population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone's modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.

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Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

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“…The associations between stress and itch in patients with AD constitute a problem of particular complexity and importance and involve the components of the so-called neuro-endocrino-immunocutaneous system (NEICS) and the hypothalamo-pituitary-adrenal (HPA axis). The relevant aspects of this issue are covered in detail elsewhere (33)(34)(35)(36)(37)(38), although there is evidence that acute or chronic stress have different impacts on the HPA axis (39).…”

Section: Itch and Stressmentioning

confidence: 99%

Itch and Psyche: Bilateral Associations

Reszke¹,

Szepietowski²

2020

Acta Derm Venerol

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The relationship between itch and psyche is complex and bilateral. Increasing interest in itch and its associations with psyche is indicated by the abundance of experimental and clinical articles published in this field. This review covers the pathogenesis of itch, associations with stress, the contagiousness of itch, psychological and psychiatric aspects related to itch, and the burden of itch with respect to impairment of health-related quality of life and stigmatization. Beginning from embryological development, skin and psyche are closely related to physiological state regardless of age. Altering the homeostasis of one of these components impacts on the other, thereby substantiating that the relationship between itch and psyche is bilateral. Itch has a complex pathogenesis, which involves the peripheral and central nervous systems, as well as various inflammatory mediators. This paper reviews key aspects of itch pathogenesis, relevant associations with stress, the contagiousness of itch, psychological and psychiatric considerations related to itch, and the burden of itch with respect to impairment of health-related quality of life (HRQoL) and stigmatization. Despite the fact that itch-psyche associations still pose many questions, current knowledge supports the role of a holistic, interdisciplinary approach to these patients in order to improve their well-being.

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“…Olive oil contains linoleic acid, which is defined as an essential fatty acid for humans that is beneficial for skin health by overcoming problems related to scaly skin, eczema, and dry skin. Olive oil helps with pressure problems associated with thrombotic and vasoconstriction issues, especially in the peripheral circulation system (Lin, Zhong, & Santiago, 2017). Olive oil has a hard nature to remove the remains of dead skin but is soft for the skin.…”

Section: Discussionmentioning

confidence: 99%

Use of Olive Oil and Warm Water in Bathing Intervention in Preventing Risk of Skin Integrity Damage in Total Care Patients With Chronic Disease: A Case Study

Pele

Waluyo

2019

JPKI

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Chronic disease in total care patients can lead the damage of skin integrity. The skin integrity damage can be affected by various patient’s conditions, including physical immobilization, treatment, changes in skin turgor, immune decline, age, environmental changes and the effects of the diseases. Its can make the complications of patient condition such as infection so that can causes the longer length of stay and higher of hospitalization costs. The aim of this paper is to identified use of olive oil and warm water in bathing intervention in preventing risk of skin integrity damage in total care patients with chronic disease. This is a case study in one total care patient with chronic disease. Skin integrity assesed by Braden score and patient condition assesed by reseacher observations. Bathing the patient using olive oil and warm water has a calming effect on the patient and preventing damage to the integrity of the skin. Use of olive oil and warm water in bathing intervention can preventing risk of skin integrity damage in total care patients with chronic disease.ABSTRAKPenyakit kronis pada pasien dengan perawatan total dapat menyebabkan kerusakan integritas kulit. Kerusakan integritas kulit dapat dipengaruhi oleh berbagai kondisi pasien, termasuk imobilisasi fisik, perawatan, perubahan turgor kulit, penurunan kekebalan, usia, perubahan lingkungan dan efek penyakit. Hal ini dapat menyebabkan komplikasi pada kondisi pasien seperti infeksi sehingga dapat menyebabkan lama hari rawat lebih lama dan biaya rawat inap yang lebih tinggi. Tujuan dari tulisan ini adalah untuk mengidentifikasi penggunaan minyak zaitun dan air hangat dalam intervensi memandkani dalam mencegah risiko kerusakan integritas kulit pada pasien perawatan total dengan penyakit kronis. Ini adalah studi kasus pada satu pasien perawatan total dengan penyakit kronis. Integritas kulit dinilai oleh Braden score dan kondisi pasien dinilai dengan pengamatan peneliti. Memandikan pasien dengan minyak zaitun dan air hangat memiliki efek menenangkan pada pasien dan mencegah kerusakan integritas kulit. Penggunaan minyak zaitun dan air hangat dalam intervensi mandi dapat mencegah risiko kerusakan integritas kulit pada pasien perawatan total dengan penyakit kronis.

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Association between Stress and the HPA Axis in the Atopic Dermatitis

Cited by 82 publications

References 124 publications

Environmental risk factors and epigenetic alternations in psoriasis

Environmental risk factors and epigenetic alternations in psoriasis

Itch and Psyche: Bilateral Associations

Use of Olive Oil and Warm Water in Bathing Intervention in Preventing Risk of Skin Integrity Damage in Total Care Patients With Chronic Disease: A Case Study

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