Association Between Subclinical Hypothyroidism and Blood Pressure - A Meta-Analysis of Observational Studies

Ye, Yicong; Xie, Hongzhi; Zeng, Yong; Zhao, Xiliang; Tian, Zhuang; Zhang, Shuyang

doi:10.4158/ep13237.or

Cited by 39 publications

(28 citation statements)

References 39 publications

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“…Similarly, the present study implied that hypertension augments the total cSVD burden by 2.0‐fold (OR=2.002; 95%CI: 1.120‐3.340, P =.008). Previous cross‐sectional studies have consistently found an association between hypertension and SCH or higher TSH levels . Therefore, the link between SCH and the total cSVD burden may be partly mediated by hypertension.…”

Section: Discussionmentioning

confidence: 88%

Subclinical hypothyroidism and risk of cerebral small vessel disease: A hospital‐based observational study

Zhang

Xie

Ding

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 88%

Subclinical hypothyroidism and risk of cerebral small vessel disease: A hospital‐based observational study

Zhang

Xie

Ding

et al. 2017

Clinical Endocrinology

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“…Moreover, serum TSH was positively associated with total cholesterol and triglycerides among a cohort of 2,771 euthyroid Hispanic individuals and serum free T4 was positively correlated with serum HDL-C (331). Two meta-analyses found that systolic (332,333) and diastolic BP (333) were higher in the SHypo group than in euthyroid controls.…”

Section: Lipids Blood Pressure and Nonalcoholic Fatty Liver Diseasementioning

confidence: 94%

Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders

2019

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“…Thyroid hormones have different effects on the cardiovascular system. Subclinical hypothyroidism (SCH) has been associated with unfavorable effects, such as worsening blood pressure [3] , atherogenic dyslipidemia [4] , impaired cardiac contractile and diastolic function [5] , increased systemic vascular resistance [6] , endothelial dysfunction [6] , accelerated atherosclerosis [7] , enhanced in ammation level [8] , hypercoagulability, insulin resistance and oxidative stress [7] , all of which may increase the risk of death.…”

Section: Introductionmentioning

confidence: 99%

The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention

Liu

Wei

Wang

et al. 2020

Preprint

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Abstract BackgroundSubclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older patients undergoing PCI. Methods and Results 3168 patients aged 65 years or older who underwent PCI from January 2012 to October 2013 were included. Patients were divided into SCH group (n = 320) and euthyroidism (ET) group (n = 2848) based on thyroid function test. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) of all-cause death and cardiac death for patients with SCH during a 4-year follow-up period. There were 227 deaths during the follow-up period including 124 deaths caused by cardiac events. There was no significant difference in mortality rate between the SCH group and the ET group (p > 0.05). After adjustment for covariates, compared with patients with ET, the RRs of death from all-cause and cardiac in patients with SCH were 1.261 (95%CI: 0.802–1.982, p = 0.315) and 1.231 (95%CI: 0.650–2.334, p = 0.524), respectively. When SCH was stratified by age, gender, and degree of thyroid-stimulating hormone elevation, no significant associations were also found in any stratum. Conclusion Our investigation revealed that SCH was negatively associated with the outcome of PCI in older patients.

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Association Between Subclinical Hypothyroidism and Blood Pressure - A Meta-Analysis of Observational Studies

Cited by 39 publications

References 39 publications

Subclinical hypothyroidism and risk of cerebral small vessel disease: A hospital‐based observational study

Subclinical hypothyroidism and risk of cerebral small vessel disease: A hospital‐based observational study

Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders

The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention

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