Association between systemic inflammation and serum prostatespecific antigen in a healthy Korean population

Abstract

Objective: Serum prostate-specific antigen (PSA) may be elevated in healthy men with systemic inflammation. We aimed to investigate the association between systemic inflammation markers and serum PSA in a healthy Korean population. Material and methods:A cohort of 20,151 healthy native Korean men without prostate disease between the ages of 40 and 65 years who underwent medical checkups were studied from January 2007 to December 2013. Serum total PSA and serum C-reactive protein concentrations, neutrophil, lymphocyte, and platelet counts were determined. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated. We checked the correlation between systemic inflammation markers and PSA.Results: Data obtained from 18,800 healthy men were analyzed. The mean age of the study subjects was 50.72±7.62 years and the mean NLR was 1.764±0.804. Correlation analysis after adjustment for age and body mass index (BMI) revealed that neutrophil count (coefficient = 0.028, p value <0.001), and NLR (coefficient = 0.027, p value <0.001) correlated with PSA. Multivariate analysis using the full model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.043 respectively). Multivariate analysis using a stepwise model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.040, respectively) and BMI was negatively correlated with PSA (p<0.001). Conclusion:Systemic inflammation markers are useful with a serum PSA in a healthy Korean population. NLR in particular is significantly associated with serum PSA.

Systematic review and meta-analysis of the associations between body mass index, prostate cancer, advanced prostate cancer, and prostate-specific antigen

“…Of the 34 studies providing information on the association between BMI (as a continuous variable) and PSA [25,27,28,, 15 studies (42%) could not be included in the meta-analysis due to insufficient data but were included in an albatross plot [131][132][133][134][135][136][137][138][139][140][141][142][143][144][145]. All included studies are detailed Fig.…”

Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer

“…There was no statistically significant difference in the distribution of baseline characteristics between the two treatment groups (Table 1). The median number of assessments in the study cohort was 25 (IQR: [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Median follow-up for surviving patients was 52.3 months (IQR: 51.6-53.5) for the abiraterone arm and 51 months (IQR: 50-52) for the ADT alone arm.…”

“…In a large population-based study, higher baseline NLR or PLR and lower baseline hemoglobin (Hb) were associated with increased risk of mortality [24]. Similarly, prior work has demonstrated the prognostic association of baseline hemoglobin and PSA with OS in de novo mHSPC [25][26][27]. However, given the inherent limitation of static baseline prognostic models [28], they fail to show the real-time association of survival with dynamic changes in these markers over time, which potentially reflects a combined time-and treatment-dependent variation in the underlying disease process among patients [29,30].…”

Elevation of Serum Prostate-Specific Antigen Levels in Males With Pulmonary Embolism

“…Interesting, a positive association between serum PSA levels and systemic inflammatory markers has been demonstrated in healthy population. 21 Similarly, systemic inflammatory markers are associated with elevated serum PSA levels in males without known prostatic diseases. 22 Serum PSA levels have been suggested to be positively correlated with CRP levels in the general population.…”