Association between telomere length and BCL2 gene rearrangements in low- and high-grade non-Hodgkin lymphomas

Cottliar, Alejandra; Noriega, Maria Fernanda; Narbaitz, Marina; Rodríguez, Antonio E. Pérez; Slavutsky, Irma

doi:10.1016/j.cancergencyto.2006.05.016

Cited by 9 publications

(12 citation statements)

References 44 publications

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“…They suggested that TL is a more dynamic factor that do not correlate simply with GC-related origin but also would reflect the telomere shortening and lengthening process. In our experience, MM had the longest telomeres (16), DLBCL (unpublished data) intermediate TL, and FL (18) and MCL the shortest TRFs, supporting the hypothesis of Walsh et al (19), and probably reflecting the different proliferative activity in tumors during malignant transformation.…”

Section: Discussionsupporting

confidence: 88%

“…GC‐derived neoplasms have long telomeres, and postGC‐derived malignancies showed intermediate TL. Other authors (19) found that CLL and MCL had the shortest TRFs, diffuse large B‐cell lymphoma (DLBCL) and FL showed somewhat longer telomeres, whereas hairy cell leukemia and lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia displayed the longest telomeres. They suggested that TL is a more dynamic factor that do not correlate simply with GC‐related origin but also would reflect the telomere shortening and lengthening process.…”

Section: Discussionmentioning

confidence: 97%

“…A number of studies have observed telomere shortening in different histological subtypes of NHL (18–20), reflecting the heterogeneity of TL in B‐cell malignancies. Ladetto et al.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have observed telomere shortening in different histological subtypes of NHL (18)(19)(20), reflecting the heterogeneity of TL in B-cell malignancies. Ladetto et al (17) found a correlation between TL and tumor histopathogenesis in relation to the germinal center (GC) origin.…”

Section: Discussionmentioning

confidence: 99%

“…Different reports showed a wide heterogeneity among TL in B cell malignancies (16)(17)(18)(19)(20). In this study, we evaluated at molecular level, the modifications in the TL, measured by terminal restriction fragments (TRF) assay in tumor cells from patients with MCL.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of telomere length in mantle cell lymphoma

Cottliar

Panero

Pedrazzini

et al. 2009

European J of Haematology

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Mantle cell lymphoma (MCL) is a well defined lymphoid neoplasm genetically characterized by the t(11;14)(q13;q32). Telomeres play an essential role in preserving chromosomal integrity and genomic stability; their shortening can lead to telomere dysfunction and chromosomal instability, a critical factor in cancer development. In this study, telomere length (TL) measured by terminal restriction fragments (TRF) assay in DNA samples of tumor cells from 20 patients with MCL was evaluated. Results were correlated with clinical, morphologic and cytogenetic characteristics. In all cases, the presence of the CCND1/IGH@ rearrangement was confirmed by fluorescence in situ hybridization and/or PCR analysis. TL in total MCL patients revealed a mean TRF value (4.51 +/- 0.79 kb) significantly shorter than those observed in controls (7.49 +/- 1.94 kb) (P < 0.001); 30% of patients had TL shorter than 4.0 kb. TRF length was not associated with patients age (P = 0.07; r = 0.17) nor with sex (females: 4.33 +/- 0.51 kb and males: 4.57 +/- 0.85 kb; P = 0.63). No significant differences were found between patients studied at diagnosis (13) (4.44 +/- 0.81 kb) respect to those analyzed at relapse (7) (4.63 +/- 0.82 kb) (P = 0.53). In addition, we compared patients with (4.84 +/- 1.09 kb) and without (4.40 +/- 0.68 kb) complex karyotypes (P = 0.45) and cases with typical morphology (4.48 +/- 0.79 kb) vs. blastoid variant (4.63 +/- 1.04 kb) (P = 0.83), and no significant differences between them were found. Although the number of cases of our series is not large, our results showed that TL reduction in MCL is independent of the clinical characteristics, morphology and karyotype.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 97%

“…A number of studies have observed telomere shortening in different histological subtypes of NHL (18–20), reflecting the heterogeneity of TL in B‐cell malignancies. Ladetto et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of telomere length in mantle cell lymphoma

Cottliar

Panero

Pedrazzini

et al. 2009

European J of Haematology

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The use of telomere length in ecology and evolutionary biology

2010

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The measurement of telomere length (TL) is a genetic tool that is beginning to be employed widely in ecological and evolutionary studies as marker of age and fitness. The adoption of this approach has been accelerated by the development of telomere quantitative PCR, which enables the screening of large numbers of samples with little effort. However, the measurement and interpretation of TL change need to be done with a necessary level of rigour that has thus far often been missing where this approach has been employed in an ecological and evolutionary context. In this article, we critically review the literature available on the relationship between TL, age and fitness. We seek to familiarize geneticists, ecologists and evolutionary biologists with the shortcomings of the methods and the most common mistakes made while analysing TL. Prevention of these mistakes will ensure accuracy, reproducibility and comparability of TL studies in different species and allow the identification of ecological and evolutionary principles behind TL dynamics.

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A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma

Lan

Cawthon

Shen

et al. 2009

Clinical Cancer Research

107

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Purpose: Telomere length plays an important role in the maintenance of chromosomal stability and in tumorigenesis. We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma. Experimental Design: Using a new assay to measure relative telomere length, monochrome multiplex quantitative PCR, which strongly correlates with telomere length measured by Southern blot (Spearman r = 0.91, P < 0.0001) and has high precision (coefficient of variation = 7%), we compared telomere length in peripheral WBC DNA in 107 incident male non-Hodgkin lymphoma cases and 107 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. Results: Median (10th, 90th percentile) telomere length was 1.10 (0.79, 1.43) in cases and 1.02 (0.78, 1.26) in controls (P = 0.0017, Wilcoxon sign test). There was a strong dose-response relationship between quartiles of telomere length and risk of nonHodgkin lymphoma overall [odds ratios (95% confidence intervals) by quartile: 1.0; 1.1 (0.4-2.7); 1.8 (0.7-4.9); and 3.6 (1.4-8.9); P trend = 0.003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study. Conclusion: These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. (Clin Cancer Res 2009;15(23):7429-33) Telomeres are complexes of tandem repeats of the sequence TTAGGG that cap chromosomes. They are essential for protecting chromosomal integrity (1), and shorten after every cell division. Short telomere length can cause genomic instability, which is associated with the initiation and progression of human cancers (2). At the same time, many incipient tumors can terminate their own growth by shortening their telomeres sufficiently to trigger replicative senescence or apoptosis (3). However, if sufficient numbers of mutations that promote growth and block cell senescence and apoptotic pathways accumulate in a cell before its telomeres shorten enough to trigger senescence or apoptosis and protect it from cancer, then unlimited proliferation may ensue. It follows that in some cell types, under some circumstances, long telomeres may actually increase the risk of cancer, by allowing more time and more cell divisions during which the cell can accumulate oncogenic mutations.Most epidemiologic studies have reported that relatively shorter telomere length measured in peripheral WBC and in some instances buccal cells is associated with increased risk of cancer (4-10). In contrast, some recent reports have suggested that longer telomere length may be associated with increased risk of certain tumors, such as breast cancer and melanoma (11,12). Most studies have used a case-control design (4-8), with several more recent reports using a prospective cohort design (9-11).Given that peripheral WBC contain lymphocyte subsets that derive from lymphocytic stem cells and immunologically active tissue, we...

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Association between telomere length and BCL2 gene rearrangements in low- and high-grade non-Hodgkin lymphomas

Cited by 9 publications

References 44 publications

Analysis of telomere length in mantle cell lymphoma

Analysis of telomere length in mantle cell lymphoma

The use of telomere length in ecology and evolutionary biology

A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma

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