Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis

Wei, Zhenxing; Chang, Kunpeng; Fan, Chongsheng

doi:10.1007/s00405-020-06305-z

Eur Arch Otorhinolaryngol

2020

DOI: 10.1007/s00405-020-06305-z

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Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis

Zhenxing Wei

Kunpeng Chang

Chongsheng Fan

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2024

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Changes in urinary proteome of rats before and after noise exposure

Yang,

Zhao,

Gao

2024

Preprint

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This study established an acute noise exposure model in which 10 rats were exposed to a 119 dB noise environment for 9 hours daily over a period of 7 consecutive days. Proteomic analysis was performed on urine samples collected from the rats. A comparison of protein expression profiles before and after noise exposure identified 219 differentially expressed proteins, 30 of which are known to be associated with hearing loss. Notably, Gelsolin plays a critical role in regulating the growth and stability of the mechanosensory hair bundles in mammalian cochlear outer hair cells. Deficiency of Lysosome-associated membrane glycoprotein 1 has been reported to cause vacuolization and structural alterations in lysosomal membrane proteins in cochlear marginal cells, leading to hearing loss in mice. Similarly, SLIT and NTRK-like family member 6 deficiency is linked to delayed synaptogenesis and auditory dysfunction in mice. These findings indicate that high-decibel noise exposure induces significant changes in urinary protein expression, many of which are associated with auditory damage as previously reported.

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Changes in urinary proteome of rats before and after noise exposure

Yang,

Zhao,

Gao

2024

Preprint

View full text Add to dashboard Cite

show abstract

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Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis

Cited by 1 publication

References 27 publications

Changes in urinary proteome of rats before and after noise exposure

Changes in urinary proteome of rats before and after noise exposure

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