Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players

Massidda, Myosotis; Miyamoto‐Mikami, Eri; Kumagai, Hiroshi; Ikeda, Hayato; Shimasaki, Yu; Yoshimura, Masafumi; Cugia, Paolo; Piras, Francesco; Scorcu, Marco; Kikuchi, Naoki; Calò, Carla Maria; Fuku, Noriyuki

doi:10.1080/02640414.2020.1787683

Cited by 19 publications

(47 citation statements)

References 42 publications

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“…Sample sizes ranged from 43 to 2637, and the average age of participants ranged from 19.7 to 41.3 years. While three studies also included children, their results obtained in adult subjects met our inclusion criteria 26,37,38 . Eleven studies included men exclusively, 22–29,33,37,38 one study only females 31 and five both genders 30,32,34–36 .…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies assessed the link between genetic polymorphisms and NCMI risk (injured subjects vs. non‐injured subjects), 30–37 eight studies between genetic polymorphisms and NCMI incidence, 22–27,36,38 12 between genetic polymorphisms and injury severity, 22–29,35–38 and three between genetic polymorphisms and recovery time 22,27,28 …”

Section: Resultsmentioning

confidence: 99%

“…The two most studied polymorphisms ACTN3 rs1815739 22,23,30,31,33,36,38 and COL5A1 rs12722 23,24,[27][28][29]35 were examined in seven and six of the studies, respectively. CCL2 rs2857656, SOX15 rs4227, and IGF2 rs3213221 were investigated in four studies 23,[27][28][29] ; COL1A1 rs1800012, TNC rs2104772, and TTN rs2742327 in three 23,28,29 ; ACE I/D (rs1799752) in three 23,31,37 ; ELN rs2289360 in two 28,29 ; and GDF5 rs143383 and MMP3 rs679620 also in two. 23,27 The remaining polymorphisms examined were only analyzed in one study each (Table 2).…”

Section: Overall Study Characteristicsmentioning

confidence: 99%

“…Two studies 31,37 addressed the impacts of the Angiotensin I-converting enzyme (ACE) I/D polymorphism (rs1799752). Iwao-Koizumi et al 31 found a possible relationship between NCMI risk and an ACE genotype in Japanese athletes, the DD genotype being less frequent in their non-injured group.…”

Section: Acementioning

confidence: 99%

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Genetic variations associated with non‐contact muscle injuries in sport: A systematic review

Lim

Santiago

Pareja‐Galeano

et al. 2021

Scandinavian Med Sci Sports

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Introduction Non‐contact muscle injuries (NCMI) account for a large proportion of sport injuries, affecting athletes’ performance and career, team results and financial aspects. Recently, genetic factors have been attributed a role in the susceptibility of an athlete to sustain NCMI. However, data in this field are only just starting to emerge. Objectives To review available knowledge of genetic variations associated with sport‐related NCMI. Methods The databases Pubmed, Scopus, and Web of Science were searched for relevant articles published until February 2021. The records selected for review were original articles published in peer‐reviewed journals describing studies that have examined NCMI‐related genetic variations in adult subjects (17–60 years) practicing any sport. The data extracted from the studies identified were as follows: general information, and data on genetic polymorphisms and NCMI risk, incidence and recovery time and/or severity. Results Seventeen studies examining 47 genes and 59 polymorphisms were finally included. 29 polymorphisms affecting 25 genes were found significantly associated with NCMI risk, incidence, recovery time, and/or severity. These genes pertain to three functional categories: (i) muscle fiber structural/contractile properties, (ii) muscle repair and regeneration, or (iii) muscle fiber external matrix composition and maintenance. Conclusion Our review confirmed the important role of genetics in NCMI. Some gene variants have practical implications such as differences of several weeks in recovery time detected between genotypes. Knowledge in this field is still in its early stages. Future studies need to examine a wider diversity of sports and standardize their methods and outcome measures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Overall Study Characteristicsmentioning

confidence: 99%

Section: Acementioning

confidence: 99%

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Genetic variations associated with non‐contact muscle injuries in sport: A systematic review

Lim

Santiago

Pareja‐Galeano

et al. 2021

Scandinavian Med Sci Sports

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“…The final number of participants in the case–control association analyses for fatigue fracture and muscle injury was (i) 216 athletes with fatigue fracture and 1420 athletes without fatigue fracture and (ii) 191 athletes with muscle injury and 1373 athletes without muscle injury, respectively. In J-HAP, the history of up to three sports-related injuries in the descending order of severity was assessed using a questionnaire as described previously ( 4 , 21 ). A questionnaire was designed and administered on the basis of the consensus statement made available by the Fédération Internationale de Football Association (FIFA) ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury: Potential Role of COL1A1 Variant

Miyamoto‐Mikami

Kumagai

Tanisawa

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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A Systematic Review of the Genetic Predisposition to Injury in Football

McAuley

Hughes

Tsaprouni

et al. 2022

J. of SCI. IN SPORT AND EXERCISE

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Purpose Synthesise genetic association studies investigating injury involving football players to identify which genetic variants have the most empirical evidence to date. Methods A comprehensive search of the PubMed, SPORTDiscus, and MEDLINE databases until March 11th 2022 identified 34 studies. Inclusion criteria: primary investigations, included football players, examined the association of a genetic variant with injury, and were published in English. Risk of bias was assessed using the Newcastle–Ottawa Scale. A narrative synthesis summarised results. Results There were 33 candidate gene studies and one genome-wide study, with 9642 participants across all studies (range = 43–1311; median = 227). Ninety-nine polymorphisms were assessed within 63 genes. Forty-one polymorphisms were associated with injury once. Three polymorphisms had their specific allelic associations with injury replicated twice in independent cohorts: ACTN3 (rs1815739) XX genotype was associated with an increased susceptibility to non-contact muscle injuries, ACAN (rs1516797) G allele was associated with increased susceptibility to anterior cruciate ligament (ACL) injuries, and VEGFA (rs2010963) CC genotype was associated with an increased susceptibility to ACL and ligament or tendon injuries. However, several methodological issues (e.g., small sample sizes, cohort heterogeneity, and population stratification) are prevalent that limit the reliability and external validity of findings. Conclusion At present, the evidence base supporting the integration of genetic information as a prognostic or diagnosis tool for injury risk in football is weak. Future participation of organisations in international consortia is suggested to combat the current methodological issues and subsequently improve clarity concerning the underlying genetic contribution to injury susceptibility.

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Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players

Cited by 19 publications

References 42 publications

Genetic variations associated with non‐contact muscle injuries in sport: A systematic review

Genetic variations associated with non‐contact muscle injuries in sport: A systematic review

Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury: Potential Role of COL1A1 Variant

A Systematic Review of the Genetic Predisposition to Injury in Football

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