Association between the blood manganese (Mn) and hemoglobin in patients undergoing maintenance hemodialysis

Liu, Yun; Hu, Jiangsheng; Tang, Ruiying; Guo, Haonan; Chen, Qiongmei; Qiu, Jingxian; Liu, Yan; Tan, Rongshao; Zhong, Xiaoshi

doi:10.1016/j.jtemb.2022.126947

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…Several previous reports have revealed the clinical consequences of Mn deficiency in hemodialysis patients. A low blood Mn level was independently associated with lower hemoglobin levels and anemia in patients undergoing hemodialysis [65]. This association was also observed in data and sample information of 110 hemodialysis patients downloaded from the UC San Diego Metabolomics Workbench public repository.…”

Section: Manganesesupporting

confidence: 58%

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Wakino

2023

Kidney and Dialysis

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Recently, as the number of elderly dialysis patients has been increasing, complications associated with low nutritional status such as infectious disease have had a strong influence on the prognosis of dialysis patients. Nutritional disorders are caused by the inadequate intake of the three major nutrients—proteins, fats, and carbohydrates—as well as vitamin and mineral deficiencies. Minerals are composed of various elements, including small-amount elements and trace elements, which are present in the human body in very small quantities lower than that of iron. In dialysis and predialysis patients, zinc, manganese, and selenium are the three major elements that are significantly depleted as compared to normal subjects; these deficiencies are sometimes symptomatic. Zinc deficiency is manifest as anemia, taste abnormality, and delayed wound healing, while selenium deficiency is associated with impaired cardiac function and immunocompromised condition. Zinc has multiple functions, since various enzymes, including DNA polymerase and RNA polymerase, need zinc as a cofactor, while selenium is a component of selenoproteins, including glutathione peroxidase and thioredoxin reductases, which are major antioxidative stress enzymes. These elements can only be supplemented exogenously and contribute to the sustainable QOL of dialysis patients. On the other hand, as regards other trace elements, including copper, chromium, manganese, lead, arsenic, etc., the association of their deficiency or intoxication with various involvements of dialysis patients were investigated, although all investigations were performed in cross-sectional studies or observational studies. Therefore, the supplementation of these elements is inconclusive, given the scarcity of other intervention studies. More conclusive studies are endorsed for the establishment of proper supplementation strategies.

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Section: Manganesesupporting

confidence: 58%

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Wakino

2023

Kidney and Dialysis

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“…The demographic and clinical data of these patients were extracted from the data management system for hemodialysis (Hope®, software) developed by our group [ 6 , 7 ]. Venous blood samples were collected before the hemodialysis session and sent to the clinical laboratory at our hospital within 2 h. The laboratory parameters were as follows: Kt/v, serum insulin, serum IGF-1, blood urea nitrogen (BUN), serum creatinine, serum phosphorus, serum parathyroid hormone, serum vitamin B12, serum folic acid, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol, serum total cholesterol, serum triglycerides, serum ferritin, serum transferrin, serum albumin, hemoglobin, serum prealbumin, serum interleukin-6, and serum high-sensitivity C-reactive protein.…”

Section: Methodsmentioning

confidence: 99%

Lower serum insulin-like growth factor-1 levels are independently associated with anemia in patients undergoing maintenance hemodialysis

Ren²,

Yao

et al. 2023

Renal Failure

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The relationship between serum insulin-like growth factor-1 (IGF-1) levels and anemia in patients undergoing maintenance hemodialysis (MHD) remains unclear. This cross-sectional study included patients who underwent MHD treatment for >3 months at our dialysis center in March 2021. Demographic and clinical data were recorded. Blood samples were collected before the hemodialysis sessions, and general serum biochemical parameters, routine blood markers, and serum IGF-1 levels were measured. Patients were divided into a group without anemia (hemoglobin ≥110 g/L) and a group with anemia (hemoglobin <110 g/L), and multivariable linear and binary logistic regression analyses were performed to study the relationship between the levels of serum IGF-1 and anemia. A total of 165 patients (male/female = 99:66) with MHD were enrolled in the study, with a median age of 66.0 (58.0, 75.0) years and a median dialysis vintage of 27.0 (12.0, 55.0) months. The mean hemoglobin level was 96.38 ± 16.72 g/L, and 126 patients had anemia (76.4%). Compared to patients without anemia, patients with anemia had lower serum IGF-1 and triglyceride levels and higher intravenous iron supplementation on dialysis (all p < 0.05). After adjusting for confounding factors in different models, the nine-model multivariate binary logistic regression analyses also confirmed that lower serum IGF-1 levels and serum IGF-1 < 197.03 ng/ml were both independently associated with anemia in patients undergoing MHD. However, further multicenter studies with larger sample sizes are required to confirm these findings.

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“…Its deficiency can decrease MnSOD activity and aggravate oxidative damage in human body [ 194 , 195 ]. The level of blood Mn in dialysis patients decreased, and the level of blood Mn was independently correlated with the level of hemoglobin [ 196 , 197 ]. For iron deficiency in dialysis patients [ 198 ], many studies have been conducted and their results are relatively clear; hence, we will not repeat them here.…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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Association between the blood manganese (Mn) and hemoglobin in patients undergoing maintenance hemodialysis

Cited by 7 publications

References 32 publications

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Trace Elements and Their Management in Dialysis Patients—Pathophysiology and Clinical Manifestations

Lower serum insulin-like growth factor-1 levels are independently associated with anemia in patients undergoing maintenance hemodialysis

Progress in the study of nutritional status and selenium in dialysis patients

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