Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People

Abstract

Aim:The aim of this study was to investigate the cross-sectional association between arterial stiffness (AS) measured with the cardio-ankle vascular index (CAVI) and executive function in communitydwelling elderly people. Methods: Subjects were 140 community-dwelling elderly people who participated in the study at Kobe, Japan during the period of August-September 2014, of which 126 (mean age SD: 73.2 6.1, female: 67.5%) met the inclusion criteria and completed the study. Age, sex, body mass index, global cognition, existence of chronic disease, medication, smoking history, and years of education were assessed. The degree of AS was assessed using CAVI. Executive function was assessed using the Category Word Fluency Test (CWFT), Letter Word Fluency Test (LWFT), and Digit Symbol Substitution Test (DSST). We used a correlation analysis and multiple linear regression analysis to investigate whether higher CAVI was independently associated with lower executive function.

Early Detection System of Vascular Disease and Its Application Prospect

“…A series of studies have found that CAVI as a new marker of vascular health was closely related to arterial injury in patients with hypertension, diabetes, metabolic syndrome, and blood lipid disorder and became a useful tool for health screening because of the blood pressure dependence [30–35]. In addition, higher CAVI was also associated with lower executive function in older adults [36], and CAVI was also an effective predictor of cardiovascular events in obese patients [37]. In addition, a new classification of vascular health has regarded CAVI as an important evaluation index of vessel in clinical practice [38].…”

Noninvasive Assessment of Arterial Stiffness Using Oscillometric Methods: baPWV, CAVI, API, and AVI

“…An improvement in these risk factors decreased CAVI. In the Journal of Atherosclerosis and Thrombosis , CAVI was reported to be a predictor for cardiovascular events, independent of traditional coronary risk factors in 1562 outpatients with metabolic disorders 7 ) and to be associated with the executive function assessing letter word fluency test in140 community-dwelling elderly individuals 8 ) .…”