Association between the CD14−260C>T gene polymorphism and susceptibility to myocardial infarction: Evidence from case−control studies

Abstract

Numerous published studies have investigated the relationship between the CD14−260C>T (rs2569190) polymorphism and the risk of myocardial infarction (MI). However, the results are still conflicting and inconclusive. Potentially eligible published articles were searched in four databases including PubMed, Web of Science, EMBASE and Chinese Biomedical Database (CBM). The odds ratio (OR) with its 95% confidence interval (CI) was used to estimate the strength of the associations. Thirteen papers including 17 case–control studies were included, reporting a total of 6,443 MI patients and 6,315 controls. A significant increase in overall MI susceptibility was identified in the homozygote model. In the subgroup analysis, with respect to the type of MI, a significantly increasing acute MI susceptibility was found in the homozygote model. In the subgroup analysis for ethnicity, a significant increased susceptibility was found in Asian populations in allele, homozygote, recessive and dominant models. However, no significant association was found among Caucasian populations. In conclusion, there may be a moderate association between the CD14−260C>T polymorphism and acute MI susceptibility. This association may be different between ethnicities with the CD14−260C>T polymorphism being a risk factor for myocardial infarction in Asian populations.

The Effects of Hypoxic Preconditioned Murine Mesenchymal Stem Cells on Post-Infarct Arrhythmias in the Mouse Model

“…CD14 is one the characteristic markers of classical macrophages. Known polymorphism of CD14 showed susceptibility to MI in humans [ 31 ]. CD74, also known as MIF receptor, promotes cardiac stem cell survival proliferation and differentiation [ 32 ].…”

Identification and Interaction Analysis of Molecular Markers in Myocardial Infarction by Integrated Bioinformatics Analysis

“…Molecular biology investigation have identified numerous biomarkers and signaling pathway that contribute to MI, including HMGA1 [12], STXBP2 [13], CCL19 and CCL21 [14], NLRP3 [15], CD14 [16], Nrf2 signaling pathway [17], Wnt signaling pathways [18], β2AR, cAMP/PKA, and BDNF/TrkB signaling pathways [19], PTEN/PI3K/Akt signaling pathway [20] and TGF-β1 signaling pathway [21]. A further study into the molecular events linked with MI is required.…”