Association between the Clinical Presentation and Epidemiological Features of Familial Prostate Cancer in Patients Selected for Radical Prostatectomy

Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC study

“…Following the Carter et al 10 categorization of prostate cancer into sporadic, familial, and hereditary subgroups, the clinical characteristics of HPC families, and how they differ from sporadic cases, have been the subject of considerable controversy in the literature. [16][17][18][19] A review of the clinical characteristics of 74 North American HPC families potentially linked to the HPC1 locus on chromosome 1 demonstrated three distinct clinical characteristics, including earlier age of onset, higher grade tumors, and more advanced disease at diagnosis compared to agematched sporadic cases. 20 Bratt et al 21 recently reported earlier age of onset in Swedish HPC families compared to sporadic cases, but found no differences in clinical characteristics or survival between the two groups.…”

Polymorphism L26V in the Cathepsin B Gene may be Associated with a Risk of Prostate Cancer and Differentiation

“…29 This finding is further supported by data from another study that showed no difference in clinical presentation or epidemiological features (except age of onset) when comparing familial and sporadic PCa, indicating that the two entities are the same disease. 30 The controls in the present study were drawn from a general population of younger people. For association studies of PCa, the ideal control group should comprise healthy old men without benign prostatic hyperplasia and PCa, but these samples would be difficult to find.…”

“…29 This finding is further supported by data from another study that showed no difference in clinical presentation or epidemiological features (except age of onset) when comparing familial and sporadic PCa, indicating that the two entities are the same disease. 30 The controls in the present study were…”

Diversity of cancer-related identities in long-term prostate cancer survivors after radical prostatectomy

“…Data were gathered as part of the German research project ‘Familial Prostate Cancer’, which since 1993 has prospectively recruited PCa patients regardless of a family history of PCa via collaborating urologists and clinics. Further details about the research project and its multi-centric database has been described elsewhere [ 15 , 18 ]. In short, participants receive annual questionnaires (conducted in German) concerning clinical, sociodemographic, and psychosocial information, with further clinical information being obtained through the corresponding treating urologist.…”