Association between the diagnosis of atrial fibrillation and aspects of health status: a <scp>D</scp>anish cross‐sectional study

Hoegh, Vibeke; Lundbye‐Christensen, Søren; Delmar, Charlotte; Frederiksen, Kirsten; Riahi, Sam; Overvad, Kim

doi:10.1111/scs.12272

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…The proportion of patients with low annual income was higher in women (58.7% vs. 49.8%, P < 0.001) than men. Women had higher median CHA 2 DS 2 -VASc scores (4 [2][3][4][5] vs. 2 [1-3], P < 0.001) than men. Although no significant difference was observed in HAS-BLED scores between sexes, compared with men, fewer woman had high bleeding risk (HAS-BLED scores ≥3; 15.2% vs. 18.7%, P < 0.001).…”

Section: Baseline Characteristicsmentioning

confidence: 99%

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Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation

Chen

et al. 2023

CVIA

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Background: Women with atrial fibrillation (AF) have poorer quality of life (QoL) than men; however, the factors contributing to the poorer QoL in women is unclear. Methods: We analyzed data for 3562 patients with non-valvular AF enrolled in the China Registry of Atrial Fibrillation. The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) was used to evaluate QoL, which was compared between women and men. A multivariate logistic regression analysis model was used to explore factors potentially explaining the sex difference in QoL. Results: Overall, 43.3% of the cohort comprised women (n=1541) who were older than their male counterparts (72 ± 9.8 vs. 68 ± 11.9 years, P<0.001). Compared with men, women were more likely to have more symptoms, hypertension, diabetes mellitus, and heart failure. Women were less likely than men to receive catheter ablation (4.5% vs. 6.1%, P=0.044). Women also had lower physical component summary (PCS) scores (48 ± 9 vs. 51 ± 9, P<0.001) and mental component summary (MCS) scores (49 ± 10 vs. 51 ± 10, P<0.001) than men. In the multivariable analysis of the poorer PCS scores in women, patient age explained 32.9%, low socioeconomic status explained 20.0%, lifestyle explained 14.3%, cardiovascular comorbidities explained 15.7%, the presence of more symptoms explained 5.7%, and less catheter ablation explained 1.4%. These factors also explained similar proportions of the sex difference in MCS scores. Together, these factors explained 54.3% of the poorer physical function status and 46.8% of the poorer mental function status in women than men. Conclusions: Women with AF had poorer QoL than men. The following factors partly explained the poorer QoL in women: older age, low level of socioeconomic status, more cardiovascular comorbidities, less smoking and drinking, more symptoms, and less catheter ablation.

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Section: Baseline Characteristicsmentioning

confidence: 99%

“…Atrial fibrillation (AF) is a common cardiac arrhythmia that can contribute to adverse clinical outcomes and impaired quality of life (QoL) [1][2][3]. Although women have a lower incidence of AF, they usually experience higher risk of death and stroke than men [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation

Chen

et al. 2023

CVIA

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“…Patients with AF have a significantly lower QoL than the general population as measured by various validated QoL instruments. [3][4][5]7,38 The symptoms experienced by patients with AF have been associated with a 19% impairment in functional status, based on functional capacity as measured by the Goldman Specific Activity Scale, 38 a 25% disruption to daily activities as measured using the illness intrusiveness scale, 39 and a ≤47% reduction in QoL as measured using the SF-36 QoL scale. 38,39 Patients with AF or other cardiovascular diseases such as coronary artery disease, congestive heart failure, and history of heart attack have similar reductions in QoL.…”

Section: Clinical Consequences Of Atrial Fibrillationmentioning

confidence: 99%

“…Patients with AF have an increased risk of life-threatening complications and other diseases, and AF also increases the risk for heart failure 5.0-fold, stroke 2.4-fold, and mortality 2.0-fold. 1 Furthermore, AF worsens quality of life (QoL) for patients and caregivers, [2][3][4][5][6][7] increasingly places a critical financial burden on healthcare systems, and is rapidly becoming one of the world's most significant health issues.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Burden of Atrial Fibrillation: Understanding the Impact of the New Millennium Epidemic across Europe

et al. 2019

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Atrial fibrillation (AF), the most common form of arrhythmia, is fast becoming one of the world’s most significant health issues. It is well established that AF increases the risk of mortality, and is associated with significant morbidity, including an increased risk of stroke. AF also worsens quality of life for patients, which can also be a burden for caregivers. As a result of Europe’s ageing population, the prevalence of AF is expected to rise substantially in the future. With more patients expected to be affected by AF, rates for AF-related strokes, hospitalisations, and doctor visits are also expected to rise, ultimately raising healthcare system costs across Europe. It is estimated that up to 2.6% of total annual healthcare expenditure is associated with AF in European countries. The high cost of AF is largely attributable to hospitalisations and complications such as stroke, i.e., in 2015, stroke was estimated to cost €45 billion a year in the European Union (EU). The purpose of this review is to highlight the current scale and growing burden of this new millennium epidemic in Europe. This review aims to foster a greater awareness and understanding of the magnitude of the clinical, patient, and economic burden of AF. An understanding of the burden of AF is imperative for directing care pathway management and healthcare policies that can help alleviate the burden of AF experienced by patients, caregivers, and healthcare systems in Europe.

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“…The impact of AF on social health is significant because it is associated with high mortality and morbidity, and with significantly impaired quality of life for patients and their caregivers [ 5 , 6 , 7 ]. Patients with AF have an elevated risk of clinical complications and comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Impact of Catheter Ablation Procedure on Outcomes and Economic Burden in Patients with Atrial Fibrillation: Real-World Data from Italian Administrative Databases

Esposti¹,

Dovizio²,

Leogrande³

et al. 2022

Healthcare

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A real-world analysis among the Italian population has been carried out to estimate the number of atrial fibrillation (AF) patients undergoing catheter ablation and to evaluate their clinical outcome and economic burden. A retrospective analysis on administrative Italian databases has been performed. Between January 2011 and December 2019, all patients diagnosed with AF were considered and those undergoing catheter ablation were identified. Overall, 3084 (3.54%) of AF patients with at least one catheter ablation were included (mean age 63.2, 67.3% males). A significant decrease in the use of AF-related medications and in hospitalizations, mainly related to AF and heart failure, was observed during the 3-year post-ablation period. The average total cost per patient during the 1-year before ablation period was significantly higher compared to the 1-year post-ablation cost (EUR 5248 vs. 4008, respectively; p < 0.001). After propensity score matching, the overall mortality of patients who underwent ablation was significantly lower compared to that assessed in patients not treated with the procedure (9.386/1000 vs. 23.032/1000 person-year, respectively; p < 0.001). Moreover, the mean total costs were significantly higher in patients who did not undergo ablation compared to those who received ablation (EUR 5516 vs. 4008, respectively; p < 0.001). This real-world data analysis shows that in Italy, although catheter ablation is performed in a minority of AF patients, it is associated with significantly better post-procedure clinical outcomes and a significant reduction in healthcare-related costs.

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Association between the diagnosis of atrial fibrillation and aspects of health status: a Danish cross‐sectional study

Cited by 6 publications

References 30 publications

Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation

Sex Differences in Quality of Life and their Explanatory Variables in Patients with Non-Valvular Atrial Fibrillation

A Review of the Burden of Atrial Fibrillation: Understanding the Impact of the New Millennium Epidemic across Europe

Evaluation of the Impact of Catheter Ablation Procedure on Outcomes and Economic Burden in Patients with Atrial Fibrillation: Real-World Data from Italian Administrative Databases

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