Association between the Dietary Inflammatory Index and All-Cause Mortality in Adults with Obesity

Background: Dietary Inflammation Index (DII) increases the risk of cardiovascular disease (CVD). However, few studies have revealed an association between DII with Incidence of Both All-cause and CVD Mortality among CVD populations. Methods: The effect of DII on all-cause and CVD mortality was assessed using weighted multivariable Cox proportional hazards models. Weighted restricted cubic spline (RCS) and weighted Kaplan-Meier survival curves were used to determine the linearity between DII and mortality. Subgroup analysis was performed to explore whether the effect of DII on all-cause and CVD mortality was influenced by confounding factors. Results: The data in this study were obtained from The National Health and Nutrition Examination Survey (NHANES) 2003-2018. During the mean follow-up time of 7.13 years, all-cause mortality and cardiovascular mortality were 38.96% and 13.51%, respectively. Furthermore, we found a linear relationship between the DII and all-cause and CVD mortality. After full adjustment for potential confounders (Model 3), the presence of the DII increased the risk of all-cause mortality by 4.3% (HR, 1.043; 95% CI, 1.006-.082; P-value =0.023) and the risk of CVD mortality by 8.3% (HR, 1.083; 95% CI, 1.020-1.150; P-value =0.009). Weighted Kaplan-Meier survival curves and weighted RCS plots revealed that All-cause and CVD mortality increased as DII increased. Conclusion: Elevated DII levels were independently associated with an increased risk of all-cause and CVD mortality among CVD populations. However, the existence of a causal relationship between the two needs to be explored further.

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The dietary inflammatory index and asthma prevalence: a cross-sectional analysis from NHANES

Lu,

Zhu

2024

Front. Nutr.

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BackgroundInflammation is a key factor in the development of asthma, and diet significantly influences inflammatory responses. This study examines the relationship between the Dietary Inflammatory Index (DII) and asthma prevalence.MethodsWe conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Demographic details, anthropometric measurements, dietary habits, lifestyle factors, and asthma status were recorded for all participants. Multivariable logistic regression was utilized to assess the relationship between DII and asthma prevalence. Additionally, restricted cubic spline (RCS) analysis was employed to explore the nonlinearity and dose–response relationship between DII and asthma risk. Subgroup analyses were stratified by gender, age, race, body mass index (BMI), poverty income ratio (PIR), education, smoking status, alcohol use, and family medical history to dissect the association between DII and asthma across diverse populations.ResultsThe analysis included 37,283 adults from NHANES. After adjusting for potential confounders in the multivariable logistic regression model, a significant positive association was identified between DII and asthma (OR, 95% CI: 1.05, 1.02–1.09, per 1 SD increase). The RCS analysis revealed a nonlinear association (p for nonlinearity = 0.0026), with an inflection point at 1.366, beyond which an increase in DII was significantly associated with asthma risk. Furthermore, the stratified analyses indicated a positive association between DII and asthma in the majority of subgroups.ConclusionThe findings underscore a significant and nonlinear association between DII and asthma. To enhance asthma prevention and management, greater emphasis should be placed on modulating dietary-induced inflammation.

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Association between the Dietary Inflammatory Index and All-Cause Mortality in Adults with Obesity

Cited by 3 publications

References 34 publications

The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review

The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review

The Association of Dietary Inflammation Index with Incidence of Both All-cause and Cardiovascular Mortality among US Adults with Cardiovascular Diseases

The dietary inflammatory index and asthma prevalence: a cross-sectional analysis from NHANES

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