Association between the Finnish Diabetes Risk Score and cancer in middle-aged and older adults: Involvement of inflammation

Yu, Peng; Wang, Peng; Gong, Jiyong; Liu, Fubin; Qiao, Yating; Si, Changyu; Wang, Xixuan; Zhou, Huijun; Song, Fang

doi:10.1016/j.metabol.2023.155586

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…8 Furthermore, inflammation worsened the progression of diabetes, and dysglycemia caused significant endothelial dysfunction and upregulation of inflammation within the vasculature and finally increased the risk of AMI morality. 9,10 Our study has several major strengths. Firstly, it was the first cohort study with large sample size to report the association between multifaceted sleep habits and AMI mortality among DM patients.…”

Section: Commentmentioning

confidence: 99%

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Association of healthy sleep pattern with lower risk of acute myocardial infarction mortality among people with diabetes: A prospective cohort study

Du,

Liu,

Liu

2024

Journal of Diabetes

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Association of healthy sleep pattern with lower risk of acute myocardial infarction mortality among people with diabetes: A prospective cohort study

Du,

Liu,

Liu

2024

Journal of Diabetes

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“…Long-term hyperglycemia in patients with diabetes activates the growth factor cascade in the body through neurohumoral regulation, thereby increasing the production of inflammatory cytokines and chemokines. Studies have demonstrated that diabetes can promote the secretion of VEGF, IL, TNF, NF-kB, and other inflammatory factors and chemokines, and these are closely related to the occurrence of tumors 98 , 99 ( Figure 2 ). Additionally, NF-kB is a regulatory factor that inhibits apoptosis.…”

Section: The Underlying Mechanisms Of Diabetes and Thyroid Cancermentioning

confidence: 99%

“…Figure 2Increased secretion of inflammatory factors and chemokines promotes the occurrence and progression of thyroid cancer. Note: Data from these studies 98,99. …”

mentioning

confidence: 99%

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Wu,

Zhang,

Zou

et al. 2024

DMSO

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The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. The relationship between thyroid cancer and diabetes is a popular topic in medicine. Increasing evidence has shown that diabetes increases the risk of thyroid cancer to a certain extent. This mechanism may be related to genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia, elevated insulin-like growth factor-1 levels, abnormal secretion of adipocytokines, and increased secretion of inflammatory factors and chemokines. This article reviews the latest research progress on the relationship between thyroid cancer and diabetes, including the association between diabetes and the risk of developing thyroid cancer, its underlying mechanisms, and potential anti-thyroid cancer effects of hypoglycemic drugs. It providing novel strategies for the prevention, treatment, and improving the prognosis of thyroid cancer.

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“…The Finnish Diabetes Risk Score (FINDRISC) is a functional tool designed in Finland to identify people at high risk of developing T2DM. An article published recently found that a higher FINDRISC is related to increased cancer incidence and mortality, a risk factor that is partially mediated by low-grade inflammation [ 55 ].…”

Section: Cancer Influencing Diabetes and Viceversamentioning

confidence: 99%

Diabetes and Cancer: A Twisted Bond

Cosmin Stan,

Paul

2024

Oncol.Rev.

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This paper presents an overview of the interconnection between various factors related to both cancer and type 2 diabetes mellitus (T2DM). Hyperglycemia, hyperinsulinemia, chronic inflammation, and obesity are involved in the development and progression of both diseases but, strong evidence for a direct causal relationship between diabetes and cancer, is lacking. Several studies described a relationship between hyperglycemia and cancer at the cellular, tissular and organismic levels but at the same time recent Mendelian randomization studies proved a significant causal relationship only between hyperglycemia and breast cancer. On the other hand, the association between both hyperinsulinemia and obesity and several cancer types appears to be robust as demonstrated by Mendelian randomized studies. Metabolic alterations, including the Warburg effect and excessive glucose consumption by tumors, are discussed, highlighting the potential impact of dietary restrictions, such as fasting and low-carb diets, on tumor growth and inflammation. Recent data indicates that circulating branched-chain amino acids levels, may represent novel biomarkers that may contribute to both better diabetes control and early pancreatic cancer detection. Understanding the underlying mechanisms and shared risk factors between cancer and T2DM can provide valuable insights for cancer prevention, early detection, and management strategies.

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Association between the Finnish Diabetes Risk Score and cancer in middle-aged and older adults: Involvement of inflammation

Cited by 7 publications

References 39 publications

Association of healthy sleep pattern with lower risk of acute myocardial infarction mortality among people with diabetes: A prospective cohort study

Association of healthy sleep pattern with lower risk of acute myocardial infarction mortality among people with diabetes: A prospective cohort study

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Diabetes and Cancer: A Twisted Bond

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