Association between the <i>miRNA‐149</i> rs2292832 T&gt;C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

Li, Jiawen; Su, Xiaoping; Jiang, Zhi‐Yong; Rong, Xing; Gu, Xueping; Jia, Chang; Zeng, Ling‐Li; Zheng, Hao; Gu, Xiaoqiong; Chu, Maoping

doi:10.1002/jcla.23125

“…The miR-146a “rs57095329” variant was associated with increased SLE risk in East Asian regions [ 74 , 79 , 80 ]. The miR-149 rs2292832 polymorphism may confer susceptibility to Kawasaki disease [ 81 ], allergic rhinitis, and comorbid asthma in Chinese children [ 82 ]. The association of the miRNA-34a rs2666433 variant with SLE susceptibility and the miR-17 rs4284505 variant with susceptibility and severity of SLE were also evident in the present cohort [ 2 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous

Khired

¹

,

Kattan

²

,

Alzahrani

³

et al. 2023

Life

0

View full text Add to dashboard Cite

Multiple microRNAs (miRs) are associated with systemic autoimmune disease susceptibility/phenotype, including systemic lupus erythematosus (SLE). With this work, we aimed to unravel the association of the miR-27a gene (MIR27A) rs11671784G/A variant with SLE risk/severity. One-hundred sixty-three adult patients with SLE and matched controls were included. A TaqMan allelic discrimination assay was applied for MIR27A genotyping. Logistic regression models were run to test the association with SLE susceptibility/risk. Genotyping of 326 participants revealed that the heterozygote form was the most common genotype among the study cohort, accounting for 72% of the population (n = 234), while A/A and G/G represented 15% (n = 49) and 13% (n = 43), respectively. Similarly, the most prevalent genotype among cases was the A/G genotype, which was present in approximately 93.3% of cases (n = 152). In contrast, only eight and three patients had A/A and G/G genotypes, respectively. The MIR27A rs11671784 variant conferred protection against the development of SLE in several genetic models, including heterozygous (G/A vs. A/A; OR = 0.10, 95% CI = 0.05–0.23), dominant (G/A + G/G vs. AA; OR = 0.15, 95% CI = 0.07–0.34), and overdominant (G/A vs. A/A + G/G; OR = 0.07, 95% CI = 0.04–0.14) models. However, the G/G genotype was associated with increased SLE risk in the recessive model (G/G vs. A/A+ G/G; OR = 17.34, 95% CI = 5.24–57.38). Furthermore, the variant showed significant associations with musculoskeletal and mucocutaneous manifestations in the patient cohort (p = 0.035 and 0.009, respectively) and platelet and white blood cell counts (p = 0.034 and 0.049, respectively). In conclusion, the MIR27A rs11671784 variant showed a potentially significant association with SLE susceptibility/risk in the studied population. Larger-scale studies on multiethnic populations are recommended to verify the results.

show abstract

“…The rs2292832 T>C mutation of miR-149 may affect its expression and susceptibility to disease [40,63]. miR-149 is a proapoptotic miRNA that affects the expression of the Akt1 15 Disease Markers and E2F1 gene, which has been shown to promote cell growth and cell cycle progression in IBD-associated colorectal cancer [120].…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

Zhang

¹

,

Tan

²

,

Cao

³

et al. 2021

View full text Add to dashboard Cite

Purpose. Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. Methods. Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. Results. In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08 , 95% CI: 1.01-1.15, P = 0.019 ; allele model, OR = 1.09 , 95 CI: 1.05-1.15, P < 0.001 , respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92 , 95% CI: 0.88-0.97, P = 0.001 ) as well as miR-499 rs3746444 (allele model, OR = 1.16 , 95% CI: 1.03-1.29, P = 0.011 ). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15 , 95% CI: 1.06-1.24, P < 0.001 ; allele model, OR = 1.11 , 95% CI:1.01-1.22, P = 0.043 , respectively). Conclusions. Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.

show abstract

“…Although no significant correlation was revealed, the subgroup analysis showed that the rs1625579 T>G polymorphism of miRNA-137 increased the risk of KD in southern Chinese children aged<12 months. Later, several one-center studies demonstrated that the miR-218 rs11134627 A>G, miR-146a rs2910164 C>G, miR-196a2 rs11614913 T >C, miRNA-149 rs2292832 T >C polymorphisms are not associated with the susceptibility of Kawasaki disease ( 64 – 67 ). However, these results still need to be confirmed in a multi-center study involving of larger sample.…”

Section: The Inherent Mechanism Of Mirnas In Kawasaki Diseasementioning

confidence: 99%

MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring

Xiong

¹

,

Xu

²

,

Zhang

³

et al. 2022

View full text Add to dashboard Cite

Kawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susceptibility, infection, and immunity. In recent years, many studies revealed that miRNAs, a novel class of small non-coding RNAs, may play an indispensable role in the development of KD via differential expression and participation in the central pathogenesis of KD comprise of the modulation of immunity, inflammatory response and vascular dysregulation. Although specific diagnose criteria remains unclear up to date, accumulating clinical evidence indicated that miRNAs, as small molecules, could serve as potential diagnostic biomarkers and exhibit extraordinary specificity and sensitivity. Besides, miRNAs have gained attention in affecting therapies for Kawasaki disease and providing new insights into personalized treatment. Through consanguineous coordination with classical therapies, miRNAs could overcome the inevitable drug-resistance and poor prognosis problem in a novel point of view. In this review, we systematically reviewed the existing literature and summarized those findings to analyze the latest mechanism to explore the role of miRNAs in the treatment of KD from basic and clinical aspects retrospectively. Our discussion helps to better understand the pathogenesis of KD and may offer profound inspiration on KD diagnosis, treatment, and prognosis.

show abstract

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

Cited by 4 publications

References 55 publications

Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous

Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous

Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring

Contact Info

Product

Resources

About