Association Between the <i>Taq</i>I (rs731236 T&gt;C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis

Wei, Lei; Tian, Haonan; Xia, Yinlan

doi:10.1089/gtmb.2020.0263

Cited by 9 publications

(7 citation statements)

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“…In our study, the frequency of T (known as T because it is not cleaved by Taq I) and C (also known as t because it is cleaved) alleles of the CC, CT and TT genotypes did not show significant differences between groups, indicating that this polymorphism does not contribute to oral mucositis. In contrast to our data, the CC/CT genotype was associated with periodontitis (Hamrun et al, 2022) and the C allele and CC genotype were associated with caries risk in children (Lei et al, 2021).…”

Section: Discussioncontrasting

confidence: 99%

“…The Bsm I (rs1544410), Fok I (rs2228570) and Taq I (rs731236) polymorphisms in the VDR gene are among the most studied and have been associated with oral diseases such as cancer, lichen planus, caries, periodontitis and temporomandibular disorders (Bektas‐Kayhan et al, 2010; Hamrun et al, 2022; Kujundzic et al, 2016; Lei et al, 2021; Yildiz et al, 2021). VDR methylation status was assessed in hand‐foot‐and‐mouth disease associated with enterovirus 71 in children (Li et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

et al. 2022

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ObjectiveTo investigate the relationship between the polymorphisms rs1544410 (BsmI), rs2228570 (FokI) and rs731236 (TaqI) and DNA methylation status in the VDR gene (vitamin D receptor) with oral mucositis (OM) in oncopaediatric patients treated with methotrexate (MTX®).MethodsThe population comprised healthy patients with haematological malignancies aged between 5 and 19 years. An evaluation of oral conditions was performed using the Oral Assessment Guide. Demographic, clinical, biochemical and haematological data were obtained from medical records. Genomic DNA from oral mucosal cells was used for the analysis of polymorphisms (n = 102) (PCR‐restriction fragment length polymorphism) and DNA methylation (n = 81) (methylation‐specific PCR).ResultsMales predominated (57.8%), and the mean age was 10.3 years (±4.7). OM affected 84.3% of patients, of which 53.1% developed severe oral mucositis (SOM). Patients with OM had lower platelet and leukocyte counts (p < 0.05). The G allele of rs1544410 (p = 0.040) and the CT genotype of rs2228570 polymorphisms were associated with SOM (p = 0.038). A partially methylated status in the VDR promoter was found in all patients.ConclusionOM is associated with lower leukocyte and platelet counts. SOM is associated with the rs1544410 and rs2228570 polymorphisms. The methylation status of the VDR is not associated with inflammation or exposure to MTX®.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

et al. 2022

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“…We found that homozygous (TT or CC) genotype at the rs731236 locus was associated with a 1.33-fold higher risk of caries than the heterozygous (TC) genotype (OR = 1.33, 95% CI 1.06-1.67, P = 0.02), which differs from the ndings of Lei et al [40] In Lei's study, rs731236 polymorphism with dental caries in the allele contrast model (C vs. T) and in the recessive genetic model (CC vs. TT/CT). This may be because, in our study, the subjects included were all ≤ 18 years old, and the oral environment, dietary habits, and microbial ora of adolescents differ from those in middle-aged and older adults [41] , who were also included in the study by Lei et al Moreover, basal and induced VDR expression can be regulated by environmental, genetic, and epigenetic factors [42] , which may account for the observed differences in research results.…”

Section: Discussioncontrasting

confidence: 90%

“…An insertion/deletion polymorphism in the gene encoding angiotensin converting enzyme may be related to permanent tooth caries but not to primary tooth caries, especially in women in the Czech population [45] . This study found similar results, in that the homozygous (TT or CC) genotype of rs731236 was associated with a higher risk of dental caries in permanent teeth than the heterozygous (TC) genotype under the overdominant genetic model (OR = 1.48, 95% CI: 1.07-2.03, P = 0.02), similar to the ndings of Lei et al [40] , suggesting that genetic polymorphisms at the rs731236 locus are likely to affect the incidence of dental caries in permanent teeth but not in primary and mixed dentition.…”

Section: Discussionsupporting

confidence: 89%

Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Qin,

Wang,

Wang

et al. 2024

Preprint

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Background In this study, we aimed to evaluate the association of Vitamin D receptor (VDR) gene polymorphisms with caries risk in children (< 18 years).Methods The electronic databases PubMed, Cochrane, EMBASE, Web of Science, CNKI, Cqvip, and Wanfang were searched for observational studies on the relationship between VDR polymorphisms and caries, including cohort, case-control, and cross-sectional studies. Quality assessment of selected studies was conducted using the Newcastle Ottawa scale. Odds ratios (OR) with 95% confidence intervals (CI) values for associations of individual VDR polymorphisms with dental caries were calculated based on four genetic models: allelic, recessive, dominant, and overdominant. Of 79 studies considered, 10 (nine case-control and one cross-sectional) were selected for analysis; the studies involved seven VDR single nucleotide polymorphisms: rs731236, rs739837, rs10735810, rs2228570, rs7975232, rs1544410, and rs11568820.Results Alleles C and T of rs10735810 were significantly differently distributed in the caries and caries-free groups (OR = 1.33, 95% CI: 1.30–2.30, P = 0.03), with CC + CT genotypes at this locus associated with greater risk of developing caries than the TT genotype (OR = 1.87, 95%CI: 1.15–3.04, P = 0.01). Further, TT + CC genotype at rs731236 was associated with a 1.33-fold higher risk of caries development than the TC genotype (OR = 1.33, 95%CI:1.06–1.67,P = 0.02). On subgroup analysis, the association between rs731236 and caries risk was affected by dentition type, ethnicity, and genotyping method (permanent dentition: OR = 1.48, 95%CI: 1.07–2.03, P = 0.02; Asian: OR = 1.38, 95%CI: 1.02–1.87, P = 0.03; quantitative PCR test: OR = 1.52, 95% CI: 1.10–2.10, P = 0.01). Genotype distributions at rs1544410, rs739837, rs2228570, and rs7975232 did not differ significantly between the caries and caries-free groups.Conclusions Caries risk was associated with rs731236 and rs10735810 genotypes, and rs731236 may be a risk factor for permanent teeth caries among Asian people.

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“…According to the World Health Organization, dental caries (hereafter termed "caries") is the third-leading major disease that seriously impacts human health (after cancer and cardiovascular disease; Lei et al, 2021). Consistently, a significant amount of research has been conducted on its development and etiology.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

et al. 2023

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IntroductionA lower prevalence of dental caries (hereafter termed “caries”) has been observed in children with dental extrinsic black stain (EBS).MethodsWe investigated the epidemiologic characterization of EBS and explored the possible role of the oral microbiome (OM) and gut microbiome (GM) in EBS formation and caries prevention. In an epidemiologic survey, 2,675 children aged 3–6 years were included. Thirty-eight of these children (7 children had both caries and EBS, 10 had EBS only, 11 had caries only, and 10 were healthy children) were recruited for 16S rRNA sequencing and collection of samples of supragingival plaque and feces. Collected plaque samples were divided into four groups: BCP (EBS+, caries+), BP (EBS+, caries−), CP (EBS−, caries+), and P (EBS−, caries−). Fecal samples were also divided into four groups: BCF (EBS+, caries+), BF (EBS+, caries−), CF (EBS−, caries+), and F (EBS−, caries−).ResultsEBS was observed in 12.10% of this population. Children with EBS had a significantly reduced prevalence of caries and a lower mean value of decayed–missing–filled teeth (dmft; p < 0.01). According to analyses of dental plaque, the P group had the most complex microbiome. The BCP group exhibited greater operational taxonomic unit (OTU) richness but a reduced evenness compared with the BP group, and the CP group showed greater OTU richness than the BP group. At the genus level, higher abundance of Actinomyces and Cardiobacterium species was observed in the BCP group. Higher abundance of Lautropia and Pesudopropionibacteriumin species was observed in the BP group compared with P and CP groups, respectively (p < 0.05). Veillonella species were significantly more common in P and CP groups than in BP groups, whereas Porphyromonas and Fusobacterium species were more common in the CP group (p < 0.05). With regard to the GM, the CF group exhibited greater OTU diversity than the BF group. The GM in the BCF group exhibited the most complex relationships across all fecal groups. GM groups could be distinguished by various unique biomarkers, such as Escherichia and Shigella species in the BCF group, Agathobacter and Ruminococcus species in the CF group, Lactobacillus species in the BF group, and Roseburia species in the F group. Our results suggest that EBS is a possible protective factor against early-childhood caries. Dental plaque and the GM may be relevant to EBS in primary dentition.

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Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis

Cited by 9 publications

References 33 publications

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Characterization of the oral microbiome and gut microbiome of dental caries and extrinsic black stain in preschool children

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