Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population

Abstract

Background Studies have shown that some genetic polymorphisms associated with breast cancer susceptibility may also be associated with abortion. The TOX3 gene plays a key role during the onset of breast cancer, and reproductive factors such as abortion are risk factors for breast cancer. However, there is currently no study describing the relationship between the TOX3 rs3803662 C>T polymorphism and the risk of recurrent miscarriage. Therefore, we investigated whether the TOX3 rs3803662 C>T polymorphism is associated with recurrent miscarriage susceptibility in this case‐control study. Methods We recruited 248 recurrent miscarriage patients and 392 healthy controls from the southern Chinese population and performed genotyping using the TaqMan method. Results The results showed no evidence that TOX3 rs3803662 C>T is associated with recurrent miscarriage (CT and CC: corrected OR = 1.038, 95% CI = 0.737‐1.461, P = .8321; TT and CC: adjusted OR = 0.989, 95% CI = 0.591‐1.656, P = .9659; dominant model: adjusted OR = 1.027, 95% CI = 0.742‐1.423, P = .8712; recessive model: adjusted OR = 0.969, 95% CI = 0.600‐1.566, P = .8975). Conclusion According to this study, the TOX3 rs3803662 C>T polymorphism may not be associated with recurrent miscarriage in the southern Chinese population. A larger multicenter study is needed to confirm the results.

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

“…The researchers supposed that TOX3 mutation is related to RM. Similar to the genetic polymorphism of LncRNA CCAT2, which is related to both breast cancer and RM (Che, Huang, et al, 2019a), but they did not find any significant correlation with TOX3 rs3803662 polymorphism and repeated miscarriages(W. Huang, Zhou, Li, et al, 2019).…”

Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population

“…Shi et al recently published a large meta‐analysis in which 53 polymorphisms of 37 genes were shown to be associated with RM 8 . Our laboratory had also conducted relevant researches by investigating the association between TOX3(rs3803662) and RM, but there was no significant correlation discoverd 10 . Inspiringly, other researches have found that some polymorphisms related to susceptibility of breast cancer are also participated in occurrence of RM 11‐13 .…”

“… 8 Our laboratory had also conducted relevant researches by investigating the association between TOX3(rs3803662) and RM, but there was no significant correlation discoverd. 10 Inspiringly, other researches have found that some polymorphisms related to susceptibility of breast cancer are also participated in occurrence of RM. 11 , 12 , 13 Soon after, another results we conducted 14 have noticed the polymorphism of LncRNA HULC was associated with susceptibility of recurrent spontaneous abortion, which is also associated with the promotion of breast cancer.…”