Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case–Control Studies

Abstract

Published data regarding the association between the XRCC1 Arg399Gln polymorphism and head and neck cancer (HNC) susceptibility showed inconsistent results. This meta-analysis of eligible literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of Oct 28, 2013. Summary odds ratios (ORs) with 95% CIs were used to assess the strength of association between XRCC1 Arg399Gln polymorphism and HNC susceptibility using random-effect model. A total of 27 case-control studies including 5942 cases and 9041 controls were included for analysis. Meta-analysis of total studies showed that the XRCC1 Arg399Gln variant carriers were not susceptible to HNC (AA vs. GG: OR=0.92, 95% CI=0.77-1.11; AG vs. GG: OR=1.05, 95% CI=0.76-1.44; the dominant model AA+AG vs. GG: OR=1.00, 95% CI=0.78-1.29; the recessive model AA vs. AG+GG: OR=0.91, 95% CI=0.71-1.16). Further, subgroup analyses by ethnicity and source of controls did not identify any significant associations of XRCC1 Arg399Gln polymorphism with head and neck susceptibility in any populations. Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility.

Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?

“…Polymorphisms of MTHFR C677T, 6 EPHX1 Tyr113His, 7 and CYP1B1 Leu432Val 8 have been suggested to increase HNC risk. However, a positive association of CCND1 G870A, 9 XRCC1 Arg399Gln, 10 and XPD Lys751Gln 11 with HNC susceptibility was not indicated. Thus, the functions of different gene polymorphisms for HNC risk may differ because of their exact mechanisms.…”