Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies

Abstract

BackgroundData on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.MethodsWe searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI).ResultsA total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76–0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81–1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60–1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55–0.84, Pz<0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70–0.93, Pz = 0.003, respectively), but not in dominant model (TT+TC vs. CC: OR = 0.92, 95% CI: 0.77–1.11, Pz = 0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models.ConclusionThe IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians.

Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility

“…As a potent proinflammatory cytokine, IL-1β plays an important role in many inflammation-related diseases as well as cancer. Accordingly, IL1B gene polymorphisms, especially functional SNPs -31 T>C (rs1143627) and -511 G>A (rs16944) are associated with susceptibility to a number of diseases [11] , [12] , [13] , [14] . IL-1β is also important in the pathogenesis of TB in mice [15] , and polymorphisms in the human IL1B gene have been suggested to have differing effects on TB susceptibility.…”

The Effects of Kefir on the Inflamatory Status and Thyroid Function (Experimental Study on Wistar Rats After Exposed to Chlorpyrifos)

“…The previous study has proved that increasing the levels of TNF-α and IL-1β correlated with GD. In addition, IL-1β induces production of hyaluronan by primary thyroid epithelial cells and thyroid fibroblasts, a process that may contribute to the development of goiter in GD [15][16][17][18].…”

“…IL-1β also enhances T cell-dependent antibody production by augmenting CD40 ligand and OX40 expression on T-cells. IL-1β was shown to promote differentiation of T-helper 17 (Th17) cell, the proportion of which was reported to be higher in intractable GD than that of GD in remission [15]. In fact, patients with autoimmune diseases, such as systemic lupus erythematosus (SLE), have reduced TGF-β production in their peripheral blood cell cultures.…”

“…Thyroid follicular cells apoptosis can be sensitized by pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-1β (IL-1β) or tumor necrosis factor-α (TNF-α) and IL-1β through the mediation of Fas ligand or TNF-related apoptosis-inducing ligand [12][13][14]. Previous studies proved that the levels of TNF-α and IL-1β increased also correlated with GD [15][16][17][18].…”

Genetics of acute pancreatitis

“…In a meta-analysis of 37 studies Ying recently reported that IL-1β-31C>T polymorphism might confer susceptibility to gastric cancer in the presence of H.pylori infection, indicating gene-environment interaction in gastric carcinogenesis (82). Another analysis of 11 case-control studies by Chen et al confirmed significant protection of the IL-1b-511C>T polymorphism from Grave's Disease in Asians, but not in Caucasians (15). These results may indicate that the pancreatitis risk evaluation of IL polymorphisms is more complex than previously thought and future studies should be carefully designed to consider genetic background differences, as well as additional geneenvironment interactions.…”