Association between the insulin‐like growth factor axis in serum and periodontitis in the Study of Health in <scp>P</scp>omerania: an exploratory study

Harb, Ali N.; Holtfreter, Birte; Friedrich, Nele; Wallaschofski, Henri; Nauck, Matthias; Albers, Martin; Meisel, Peter; Biffar, Reiner; Kocher, Thomas

doi:10.1111/j.1600-051x.2012.01935.x

Cited by 10 publications

(10 citation statements)

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“…This decrease may be part of a general suppression of endocrine and energy pathways as a consequence of aging [70]. It was also found in SHIP data that low values of an IGF binding protein, IGFBP-3, were associated with increased levels of periodontitis [71]. Moreover, a protective role of IGF-1 was suggested for vascular aging [72].…”

Section: Discussionmentioning

confidence: 99%

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers

et al. 2017

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Lifespan is a complex trait, and longitudinal data for humans are naturally scarce. We report the results of Cox regression and Pearson correlation analyses using data of the Study of Health in Pomerania (SHIP), with mortality data of 1518 participants (113 of which died), over a time span of more than 10 years. We found that in the Cox regression model based on the Bayesian information criterion, apart from chronological age of the participant, six baseline variables were considerably associated with higher mortality rates: smoking, mean attachment loss (i.e. loss of tooth supporting tissue), fibrinogen concentration, albumin/creatinine ratio, treated gastritis, and medication during the last 7 days. Except for smoking, the causative contribution of these variables to mortality was deemed inconclusive. In turn, four variables were found to be associated with decreased mortality rates: treatment of benign prostatic hypertrophy, treatment of dyslipidemia, IGF-1 and being female. Here, being female was an undisputed causative variable, the causal role of IFG-1 was deemed inconclusive, and the treatment effects were deemed protective to the degree that treated subjects feature better survival than respective controls. Using Cox modeling based on the Akaike information criterion, diabetes, mean corpuscular hemoglobin concentration, red blood cell count and serum calcium were also associated with mortality. The latter two, together with albumin and fibrinogen, aligned with an”integrated albunemia” model of aging proposed recently.

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Section: Discussionmentioning

confidence: 99%

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers

et al. 2017

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“…Over 90% of IGF-I is bound to IGF binding protein-3 (IGFBP-3) [9]. IGFBP-3 is also found to be increased in patients with acromegaly [3, 10]. Free serum IGF-I is considered the biologically active form of IGF-I [11].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that high IGFBP-3 levels are associated with less periodontal disease in the general population [10]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Periodontal Status in Acromegalic Patients: A Comparative Study

et al. 2012

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Aim. The aim was to compare the periodontal status of the acromegalic patients with healthy subjects from a large population-based cohort (Study of Health in Pomerania, SHIP). Materials and Methods. We studied 32 acromegalic patients (16 females) and 128 randomly selected SHIP subjects (controls) using a 1 : 4 matching. Serum IGF-I and IGFBP-3 levels were measured using the Immulite 2500 system. Periodontitis was assessed by clinical attachment loss (CAL), probing depth (PD), and number of missing teeth. Linear and logistic regression models were used to assess differences in periodontal variables between acromegalic patients and controls. Results. IGF-I levels were comparable in acromegalic patients and controls, whereas IGFBP-3 levels were significantly higher in acromegalic patients (P = 0.004). In multivariate modelling, both groups did not differ significantly with respect to mean CAL (P = 0.12) and high tooth loss (P = 0.36). Mean PD was higher in acromegalic patients by trend (B = 0.28 (−0.00; 0.56)). Conclusion. In acromegalic patients, periodontal disease severity did not differ from their healthy SHIP controls.

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“…Decreasing insulin-like growth factor 1 (IGF-1) binding proteins are associated with variable tissue outcomes, ranging from periodontal attachment loss to decreased IGF-1. (37) IGF-1 has been shown to be significantly underexpressed in periodontitis lesions compared to healthy periodontal sites. (38) MMP-9 is a well-established inflammatory marker in periodontitis; elevated expression of MMP-9 was demonstrated in close relationship to chronic periodontal disease.…”

Section: Discussionmentioning

confidence: 98%

“…Odontogenic ameloblast‐associated protein has been shown to mediate junctional epithelial attachment to teeth, is present in a healthy periodontium, and is absent in the pathologic periodontitis pocket as was created in ExP. Decreasing insulin‐like growth factor 1 (IGF‐1) binding proteins are associated with variable tissue outcomes, ranging from periodontal attachment loss to decreased IGF‐1 . IGF‐1 has been shown to be significantly underexpressed in periodontitis lesions compared to healthy periodontal sites …”

Section: Discussionmentioning

confidence: 99%

Identification of Genes Differentially Expressed in Simvastatin‐Induced Alveolar Bone Formation

et al. 2019

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Local delivery of simvastatin (SIM) has exhibited potential in preventing inflammation and limiting bone loss associated with experimental periodontitis. The primary aim of this study was to analyze transcriptome changes that may contribute to SIM's reduction of periodontal inflammation and bone loss. We evaluate the global genetic profile and signaling mechanisms induced by SIM on experimental periodontitis bone loss and inflammation. Twenty mature female Sprague Dawley rats were subjected to ligature‐induced experimental periodontitis around maxillary second molars (M2) either unilaterally (one side untreated, n = 10) or bilaterally (n = 10). After the ligature removal at day 7, sites were injected with either carrier, pyrophosphate (PPi ×3), 1.5‐mg SIM‐dose equivalent SIM‐pyrophosphate prodrug, or no injection. Three days after ligature removal, animals were euthanized; the M1‐M2 interproximal was evaluated with μCT, histology, and protein expression. M2 palatal gingiva was harvested for RNA sequencing. Although ligature alone caused upregulation of proinflammatory and bone catabolic genes and proteins, seen in human periodontitis, SIM‐PPi upregulated anti‐inflammatory (IL‐10, IL‐1 receptor‐like 1) and bone anabolic (insulin‐like growth factor, osteocrin, fibroblast growth factor, and Wnt/ β‐catenin) genes. The PPi carrier alone did not have these effects. Genetic profile and signaling mechanism data may help identify enhanced pharmacotherapeutic approaches to limit or regenerate periodontitis bone loss. © 2018 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.

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Association between the insulin‐like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study

Abstract: Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.

Cited by 10 publications

References 52 publications

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers

Evaluation of the Periodontal Status in Acromegalic Patients: A Comparative Study

Identification of Genes Differentially Expressed in Simvastatin‐Induced Alveolar Bone Formation

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