Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Abstract

Aims/IntroductionAdiponectin has been proposed to have an essential role in the regulation of insulin sensitivity and metabolism, but previous studies on levels of adiponectin in prediabetes remain inconsistent. The present study aimed to assess the differences of adiponectin levels between prediabetes patients and healthy controls by carrying out a meta-analysis.Materials and MethodsWe carried out a systematic literature search of PubMed, EMBASE, and other databases for case–control studies and cohort studies measuring adiponectin levels in serum or plasma from prediabetes patients and healthy controls. The pooled weighted mean difference (WMD) and 95% confidence interval (CI) were used to estimate the association between adiponectin levels and prediabetes.ResultsThree cohort studies and 15 case–control studies with a total of 41,841 participants were included in the meta-analysis. The results showed that circulating adiponectin levels in prediabetes patients were significantly lower than that of healthy controls (WMD –1.694 μg/mL; 95% CI –2.151, –1.237; P < 0.001). Subgroup analysis showed more significant differences between prediabetes patients and healthy controls when the ratio of the homeostatic model assessment of insulin resistance was >2.12 (WMD −2.95 μg/mL; 95% CI –4.103, –1.806; P < 0.001) and average age was >60 years (WMD −2.20 μg/mL; 95% CI –3.207, –1.201; P < 0.001). Additionally, WMD in adiponectin showed a trend of direct correlation in subgroups of homeostatic model assessment of insulin resistance ratio, body mass index and age.ConclusionsThe present meta-analysis supports adiponectin levels in prediabetes patients being lower than that of healthy controls,indicating that the level of circulating adiponectin decreases before the onset of diabetes.

Adiponectin and pro‐inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus

“…In the normal condition, the circulating adiponectin serum levels are high in contrast to the low level of other adipocytokines 29 . In line with other studies [30][31][32][33][34][35] , the present study also showed that adiponectin levels were significantly decreased in patients with type 2 diabetes mellitus compared with individuals without type 2 diabetes mellitus. In addition, decreased adiponectin levels observed in overweight individuals supports the fact that adiponectin serum levels were inversely correlated with obesity, especially with the accumulation of visceral fat 33 .…”

Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

“…Nonetheless, due to the observational nature of our study, it remains to be elucidated whether the observed associations are causal. While experimental and animal studies clearly point towards insulin‐sensitizing properties of adiponectin, MR studies yielded mixed evidence regarding a causal role of adiponectin in the development of insulin resistance and type 2 diabetes . In line with the weak associations seen for hsCRP in the present analysis, a large previous MR study concluded that associations between CRP and insulin resistance, glycaemia and diabetes are most likely noncausal .…”

Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study

“…Another important marker for the prediabetic condition is the low level of adiponectin, an adipokine that plays a crucial role in insulin sensitivity and regulation of glucose metabolism, and is also considered a risk factor for cardiovascular disease (Banerjee et al, 2017;Lai, Lin, Xing, Weng, & Zhang, 2015). Previous studies showed citrus flavonoids positively regulate adiponectin transcription in adipocytes and increase their levels in patients with myocardial infarction (Haidari et al, 2015;Liu et al, 2008).…”