Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome

Shimono, Hirokazu; Tokushige, Akihiro; Kanda, Daisuke; Ohno, Ayaka; Hayashi, Masao; Fukuyado, Mana; Akao, Mitsumasa; Kawasoe, Mariko; Arikawa, Ryo; Otsuji, Hideaki; Chaen, Hideto; Okui, Hideki; Oketani, Naoya; Ohishi, Mitsuru

doi:10.1016/j.jjcc.2023.01.003

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…The ARC-HBR criteria have been widely used as a standardized definition of HBR in post-PCI patients 9,10) . The ARC-HBR criteria are independently associated with an increased risk of MACE in Japanese patients with acute coronary syndrome 39) . Several previous studies have found an association between J-HBR and total bleeding events in patients undergoing PCI [15][16][17][18] .…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 93%

Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction

Konoma,

Sakakura,

Jinnouchi

et al. 2024

JAT

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Aims: Bleeding complications are often observed in patients with ST-segment elevation myocardial infarction (STEMI). Although the Japanese version of the high bleeding risk criteria (J-HBR) were established, it has not been sufficiently validated in patients with STEMI. This retrospective study aims to examine whether J-HBR is associated with cardiovascular and bleeding events in patients with STEMI. Methods: We included 897 patients with STEMI and divided them into the J-HBR group ( n =567) and the non-J-HBR group ( n =330). The primary endpoint was the major adverse cardiovascular events (MACE), defined as the composite of all-cause death, non-fatal myocardial infarction, ischemic stroke, and systemic embolism. Another primary endpoint was total bleeding events defined as type 3 or 5 bleeding events as defined by the Bleeding Academic Research Consortium . Results: During the median follow-up duration of 573 days, 187 MACE and 141 total bleeding events were observed. The Kaplan–Meier curves showed that MACE and total bleeding events were more frequently observed in the J-HBR group than in the non-J-HBR group ( p ＜0.001). Multivariate Cox hazard analysis revealed that after controlling for multiple confounding factors, the J-HBR group was significantly associated with MACE (hazard ratio [HR] 4.676, 95% confidence interval (CI) 2.936–7.448, p ＜0.001) and total bleeding events (HR 6.325, 95% CI 3.376–11.851, p ＜0.001). Conclusions: J-HBR is significantly associated with MACE and total bleeding events in patients with STEMI. This study validated J-HBR as a risk marker for bleeding events and suggests J-HBR as a potential risk marker for MACE in patients with STEMI.

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Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 93%

Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction

Konoma,

Sakakura,

Jinnouchi

et al. 2024

JAT

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“…The PRECISE-DAPT score was classified into 3 categories (0–17, 18–24, ≥25), the ARC-HBR score was classified into three categories (0–0.5, 1–1.5, ≥2), and the J-HBR score was classified into four categories (0–0.5, 1–1.5, 2–2.5, ≥3). 8 , 19 , 22 Landmark analysis at 30 days was performed to distinguish between early and late events after PCI. Those patients who had individual endpoint events before 30 days were excluded from each landmark analysis beyond 30 days.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Discriminative Ability of Bleeding Risk Criteria and Scores for Predicting Short- and Mid-Term Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention

Shimono,

Tokushige,

Kanda

et al. 2024

Circ Rep

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Background: This study aimed to compare the discriminative ability of the Japanese Version of High Bleeding Risk (J-HBR), Academic Research Consortium for High Bleeding Risk (ARC-HBR), and Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) scores for predicting major bleeding events. Methods and Results: Between January 2017 and December 2020, 646 consecutive patients who underwent successful percutaneous coronary intervention (PCI) were enrolled. We scored the ARC-HBR and J-HBR criteria by assigning 1 point to each major criterion and 0.5 point to each minor criterion. The primary outcome was major bleeding events, defined as Bleeding Academic Research Consortium type 3 or 5 bleeding events. According to the J-HBR, ARC-HBR, and PRECISE-DAPT scores, 428 (66.3%), 319 (49.4%), and 282 (43.7%) patients respectively had a high bleeding risk. During the follow-up period (median, 974 days), 44 patients experienced major bleeding events. The area under the curve (AUC) using the time-dependent receiver operating characteristic curve for major bleeding events was 0.84, 0.82, and 0.83 within 30 days and 0.86, 0.83, and 0.80 within 2 years for the J-HBR, ARC-HBR, and PRECISE-DAPT scores, respectively. The AUC values did not differ significantly among the 3 bleeding risk scores. Conclusions: The J-HBR score had a discriminative ability similar to the ARC-HBR and PRECISE-DAPT scores for predicting short- and mid-term major bleeding events.

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Section: Accepted Manuscriptmentioning

confidence: 99%

“…Because of overlap of clinical risk factors for bleeding and ischemic cardiovascular events, patients identified at high risk of bleeding also exhibit a high risk of ischemic cardiovascular events. 19 20 The HAS-BLED score was similarly effective in predicting 3-year survival after myocardial infarction compared with established clinical risk scores such as the Thrombolysis In Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) scores. 19 The Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria were independently associated with an increased risk of major adverse cardiac events in patients with acute coronary syndrome after an emergent coronary intervention and the diagnostic utility was similar to that of a risk score focused on ischemia.…”

mentioning

confidence: 99%

Plasma Soluble Glycoprotein VI: A Biomarker of Bleeding

Schneider

2023

Thromb Haemost

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Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome

Cited by 5 publications

References 32 publications

Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction

Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction

Comparison of Discriminative Ability of Bleeding Risk Criteria and Scores for Predicting Short- and Mid-Term Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention

Plasma Soluble Glycoprotein VI: A Biomarker of Bleeding

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