Association between the number of oocytes retrieved and cumulative live birth rate in women aged 35–40 years undergoing long GnRH agonist IVF/ICSI cycles

Zhou, Jianjun; Wang, Bin; Hu, Yali; Sun, Haixiang

doi:10.1007/s00404-017-4503-9

Cited by 24 publications

(15 citation statements)

References 29 publications

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“…The authors concluded that the low response patient with a mean age of 31 years (1–3 oocytes) had a significantly lower cumulative LBR (22%) compared to other sub-groups, including the suboptimal response patient (4–9 oocytes) in whom the cumulative LBR was 40% and the optimal response patient (10–15 oocytes) for whom the cumulative LBR was 51%. These findings were recently corroborated by Zhou et al (2017) in patients aged 35–40 years [ 29 ]. Again, the low response patient (1–4 oocytes) had the lowest cumulative LBR (37%) as compared to other sub-groups.…”

Section: One More Oocyte Matterssupporting

confidence: 70%

Individualized controlled ovarian stimulation in expected poor-responders: an update

Haahr

Esteves

Humaıdan

2018

Reprod Biol Endocrinol

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Controlled ovarian stimulation with subsequent multi-follicular development continues to be a keystone in ART. Evidence supports an individualized approach to ovarian stimulation, usually involving combinations of ovarian reserve tests, body mass index and age to tailor the exogenous gonadotropin dose, and potentially adjuvant treatment aiming for high safety and a shortening of time to live birth. While stimulation and trigger concepts have been developed successfully in normo- and hyperresponder patients, the poor responder patient remains difficult to manage. However, recent advances in definition and classification of the expected poor ovarian responder patient might enable a more accurate and clinically useful interpretation of new treatment concepts in a more homogenous study population. In the present review, we discuss the classification of the expected poor ovarian responder patient as well as clinically useful measurements of efficacy for controlled ovarian stimulation, and finally, we discuss the evidence for clinical management of patients with expected poor ovarian response, including adjuvant treatments such as growth hormone, androgens, and LH activity.In conclusion, the best available evidence supports that the treatment of the expected poor ovarian response patient should be individualized in all steps of ART, including the choice of GnRH analogue, the gonadotropin type and dose, ovulation trigger, and the possible use of adjuvant therapies.

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Section: One More Oocyte Matterssupporting

confidence: 70%

Individualized controlled ovarian stimulation in expected poor-responders: an update

Haahr

Esteves

Humaıdan

2018

Reprod Biol Endocrinol

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“…The probability of each individual existing is very low. Each human comes from one spermatozoon out of approximately 200 million [13], that merges with one of approximately 300 thousand potential ovules [14]. To this, we add the improbability that the parents of that individual existed, and also their grandparents, great grandparents, and so on, for generations.…”

Section: Who Are We?mentioning

confidence: 99%

Human Relationships with Domestic and Other Animals: One Health, One Welfare, One Biology

Tarazona

Ceballos

Broom

2019

Animals

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Excessive human population growth, uncontrolled use of natural resources, including deforestation, mining, wasteful systems, biodiversity reduction by agriculture, and damaging climate change affect the existence of all animals, including humans. This discussion is now urgent and people are rethinking their links with the animals we use for clothing, food, work, companionship, entertainment, and research. The concepts of one health, one welfare, and one biology are discussed as a background to driving global change. Nothing should be exploited without considering the ethics of the action and the consequences. This review concerns domesticated animals, including those used for human consumption of meat, eggs, and milk; horses kept for work; and dogs kept for company. Animal welfare includes health, emotional state, and comfort while moving and resting, and is affected by possibilities to show behavior and relationships with others of the same species or with humans. We show some examples of the relations between humans and domesticated animals in the environmental context, including zoonotic diseases, and consider the consequences and the new paradigms resulting from current awareness.

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“…In other studies, some researchers also observed that the optimal number of oocytes retrieved for good CLBR and avoiding severe OHSS was 6-15 in the GnRH-antagonist protocols of non PCOS patients [9]. However, the ideal number of oocytes retrieved was 10-14 in another study of women aged 35-40 [28]. At the same time, there was a signi cant positive correlation between the number of oocytes retrieved and CLBR in a retrospective analysis of IVF-ET treatment in PCOS patients.…”

Section: Discussionmentioning

confidence: 94%

The key factors affecting cumulative live birth rate after single oocyte retrieved in women during IVF/ICSI-ET: a retrospective analysis of 1380 PCOS patients

Xia

Tan

et al. 2021

Preprint

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Background: The factors affecting the cumulative live birth rate (CLBR) of PCOS patients who received in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) are unknown.Methods: Here we carried out a retrospective analysis of 1380 PCOS patients who received IVF/ICSI-ET for the first time from January 2014 to December 2016. According to the cumulative live births of PCOS patients after single oocyte collection, they were divided into cumulative live births group (group A) and non-cumulative live births group (group B).Results: The conservative cumulative live birth rate was 63.48%. There were 876 cumulative live births (group A) and 504 non-cumulative live births (group B) according to whether the patients had live births or not. Competition analysis showed that duration of infertility, primary/secondary type of infertility, stimulation protocols, starting dose of gonadotrophins and oocyte retrieved numbers were significantly correlated with CLBR. The Cox proportional risk regression model of PCOS patients showed that stimulation protocols had a significant impact on CLBR. Patients in the GnRH-antagonist protocol group and the mild stimulation protocol had lower CLBR than those in the Prolonged GnRH-agonist protocol, which was statistically significant. PCOS patients with the starting dose of gonadotrophins greater than 112.5u had lower CLBR than those with less than 100u, which was statistically significant. Women with 11-15 oocytes and 16-20 oocytes had higher CLBR than women with 1-9 oocytes, which was statistically significant.Conclusions: According to our statistical results, patients with PCOS represent a challenge for reproductive medicine.

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Association between the number of oocytes retrieved and cumulative live birth rate in women aged 35–40 years undergoing long GnRH agonist IVF/ICSI cycles

Abstract: The ideal number of oocytes retrieved in women aged 35-40 years is 10-14 oocytes, which achieves a high cumulative LBR while maintaining an acceptable low OHSS rate.

Cited by 24 publications

References 29 publications

Individualized controlled ovarian stimulation in expected poor-responders: an update

Individualized controlled ovarian stimulation in expected poor-responders: an update

Human Relationships with Domestic and Other Animals: One Health, One Welfare, One Biology

The key factors affecting cumulative live birth rate after single oocyte retrieved in women during IVF/ICSI-ET: a retrospective analysis of 1380 PCOS patients

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