Association between the Pattern of IGFBP-1 Alteration and the Glucose/Insulin Metabolic Control

Nedić, Olgica; Masnikosa, Romana; Lagundžin, Dragana

doi:10.1055/s-0030-1267963

Cited by 3 publications

(2 citation statements)

References 18 publications

(25 reference statements)

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“…The converse is also true since infusion of a high concentration of IGFBP1 into normal rats resulted in a modest rise in plasma glucose (Lewitt & Baxter 1991). In addition to regulating IGFBP1 concentrations, glucose and insulin regulate IGFBP1 phosphorylation (Nedić et al 2011). Since phosphorylation increases the affinity of IGFBP1 for IGF1, this biochemical change regulates free IGF1 concentrations.…”

Section: Carbohydrate Metabolism and Diabetes Igfbp1mentioning

confidence: 99%

40 YEARS OF IGF1: Role of IGF-binding proteins in regulating IGF responses to changes in metabolism

Clemmons

2018

Journal of Molecular Endocrinology

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The IGF-binding protein family contains six members that share significant structural homology. Their principal function is to regulate the actions of IGF1 and IGF2. These proteins are present in plasma and extracellular fluids and regulate access of both IGF1 and II to the type I IGF receptor. Additionally, they have functions that are independent of their ability to bind IGFs. Each protein is regulated independently of IGF1 and IGF2, and this provides an important mechanism by which other hormones and physiologic variables can regulate IGF actions indirectly. Several members of the family are sensitive to changes in intermediary metabolism. Specifically the presence of obesity/insulin resistance can significantly alter the expression of these proteins. Similarly changes in nutrition or catabolism can alter their synthesis and degradation. Multiple hormones such as glucocorticoids, androgens, estrogen and insulin regulate IGFBP synthesis and bioavailability. In addition to their ability to regulate IGF access to receptors these proteins can bind to distinct cell surface proteins or proteins in extracellular matrix and several cellular functions are influenced by these interactions. IGFBPs can be transported intracellularly and interact with nuclear proteins to alter cellular physiology. In pathophysiologic states, there is significant dysregulation between the changes in IGFBP synthesis and bioavailability and changes in IGF1 and IGF2. These discordant changes can lead to marked alterations in IGF action. Although binding protein physiology and pathophysiology are complex, experimental results have provided an important avenue for understanding how IGF actions are regulated in a variety of physiologic and pathophysiologic conditions.

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Section: Carbohydrate Metabolism and Diabetes Igfbp1mentioning

confidence: 99%

40 YEARS OF IGF1: Role of IGF-binding proteins in regulating IGF responses to changes in metabolism

Clemmons

2018

Journal of Molecular Endocrinology

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“…Altered patterns of IGFBP-1 multimerisation have been reported in type 2 diabetes [74]. Levels of soluble IGF2R in the circulation are increased [6,75].…”

Section: Impaired Glucose Tolerance and Type 2 Diabetesmentioning

confidence: 99%

The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus

Lewitt

Dent

Hall

2014

JCM

120

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The insulin-like growth factor (IGF) system, acting in concert with other hormone axes, is important in normal metabolism. In obesity, the hyperinsulinaemia that accompanies peripheral insulin resistance leads to reduced growth hormone (GH) secretion, while total IGF-I levels are relatively unchanged due to increased hepatic GH sensitivity. IGF-binding protein (IGFBP)-1 levels are suppressed in relation to the increase in insulin levels in obesity and low levels predict the development of type 2 diabetes several years later. Visceral adiposity and hepatic steatosis, along with a chronic inflammation, contribute to the IGF system phenotype in individuals with metabolic syndrome and type 2 diabetes mellitus, including changes in the normal inverse relationship between IGFBP-1 and insulin, with IGFBP-1 concentrations that are inappropriately normal or elevated. The IGF system is implicated in the vascular and other complications of these disorders and is therefore a potential therapeutic target.

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Role of Cholesterol in Heart Disease

Vučić¹,

Masnikosa²

2017

Reference Module in Food Science

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Association between the Pattern of IGFBP-1 Alteration and the Glucose/Insulin Metabolic Control

Cited by 3 publications

References 18 publications

40 YEARS OF IGF1: Role of IGF-binding proteins in regulating IGF responses to changes in metabolism

40 YEARS OF IGF1: Role of IGF-binding proteins in regulating IGF responses to changes in metabolism

The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus

Role of Cholesterol in Heart Disease

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