Association between the platelet‐lymphocyte ratio and short‐term mortality in patients with non‐ST‐segment elevation myocardial infarction

Abstract

Background Previous studies have shown that inflammation plays an important role in atherosclerosis and cardiovascular disease. Platelet to lymphocyte ratio (PLR) has been reported as a novel inflammatory marker. However, it is not clear whether PLR is associated with short‐term all‐cause mortality in critically ill patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). Methods The data for the study is from the Medical Information Mart for Intensive Care III database. The primary outcome in our study was 28‐day mortality. Kapan‐Meier curve, lowess smoother curve, and multivariate Cox regression models were used to determine whether the association between PLR and 28‐day mortality of critically ill patients with NSTEMI. Results A total of 1273 critically ill patients with NSTEMI were included in this analysis. Kapan‐Meier curve and lowess smoother curve show that high PLR is associated with an increased risk of 28‐day all‐cause mortality. The study population is divided into two groups according to the cut‐off value of PLR level. In the Cox model, high PLR levels (PLR≥195.8) were significantly associated with increased 28‐day mortality (HR 1.54; 95%CI 1.09–2.18, p = .013). In quartile analyses, the HR (95% CI) for the third (183 ≤ PLR < 306) and fourth quartile (PLR≥306) was 1.55 (1.05–2.29) and 1.61 (1.03–2.52), respectively, compared to the reference group(111 ≤ PLR < 183). In subgroup analyses, there is no interaction effect in most of the subgroups except for respiratory failure and vasopressor use. Conclusion High PLR is associated with an increased risk of short‐term mortality in critically ill patients with NSTEMI.

Associations of systemic inflammatory markers with the risks of chronic heart failure: A case-control study

“…These markers are simple to calculate according to routine blood indicators and have the advantage of being inexpensive and easy to detect, which thus have been used in many clinical studies for early assessment of the prognostic risk of various cardiovascular diseases. 11 , 12 , 13 This study aims to explore the potential connections between inflammation and CHF, and the diagnostic value of systemic inflammatory indicators for CHF.…”

Platelet-to-Lymphocyte Ratio as Marker of Platelet Activation in Patients on Potent P2Y12 Inhibitors

“…13 Also, PLR has been associated with the extent of coronary and carotid artery disease, 24,25 and repeatedly linked to adverse outcomes in ACS patients. 26,27 Further, high PLR was associated with disease severity and longer hospitalizations during the current pandemia in patients infected with SARS-CoV-2. 28,29…”

“…13 Also, PLR has been associated with the extent of coronary and carotid artery disease, 24,25 and repeatedly linked to adverse outcomes in ACS patients. 26,27 Further, high PLR was associated with disease severity and longer hospitalizations during the current pandemia in patients infected with SARS-CoV-2. 28,29 Potent platelet inhibition is a mainstay in the pharmacological treatment of patients with atherosclerotic disease, 30 particularly when undergoing stent implantation, and on-treatment residual platelet reactivity has been numerously linked to adverse outcomes.…”

Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study

“…In cardiovascular disease, Akboga et al showed that PLR was an independent predictor of severe coronary artery disease (OR 1.043 [1.036–1.049], p < 0.001) and determined that an PLR > 109.5 had a sensitivity of 70%, specificity of 58% for predicting the presence of severe coronary atherosclerosis (AUC: 0.708, 95% CI: (0.68–0.73), p < 0.001) [ 16 ]. Meng et al observed that in an acute non-ST-segment elevation myocardial infarction, a PLR ≥ 195.8 was significantly associated with increased 28-day mortality (HR 1.54; 95% CI: (1.09–2.18); p = 0.013) [ 17 ].…”