Association between the presence of brown adipose tissue and non‐alcoholic fatty liver disease in adult humans

Yılmaz, Yusuf; Öneş, Tunç; Pürnak, Tuğrul; Özgüven, Salih; Kurt, Ramazan; Atuğ, Özlen; Turoğlu, Halil Turgut; İmeryüz, Neşe

doi:10.1111/j.1365-2036.2011.04723.x

Cited by 51 publications

(43 citation statements)

References 24 publications

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“…It is well known that NAFLD is the most common form of chronic liver disease and the most common cause of elevated levels of liver enzymes in healthy individuals [25]. Considering the inverse relationship between the presence of ABAT and NAFLD, our results indicating an association between the presence of ABAT and decreased levels of ALT and AST are consistent with previous reports [5,25].…”

Section: Discussionsupporting

confidence: 95%

“…It includes a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis, and cirrhosis. Recently, Yilmaz et al showed an inverse correlation between the presence of ABAT and the prevalence of NAFLD on CT scans in their study including 30 ABAT(+) subjects [5]. Our results were in agreement with those of Yilmaz et al, indicating a direct correlation between the absence of ABAT and the incidence of NAFLD.…”

Section: Discussionsupporting

confidence: 94%

“…An inverse relationship between the presence of NAFLD and ABAT has been reported [5]. Based on these data, it could be speculated that ABAT and dyslipidaemia, which is one of the factors implicated in the development of NAFLD, are negatively correlated.…”

Section: Discussionmentioning

confidence: 93%

“…In 2009, Van Marken Lichtenbelt et al found that BAT activity is negatively associated with body fat percentage and is positively associated with the basal metabolic rate under cold stress [4], and in 2011, Yilmaz et al demonstrated a reduction in the prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with ABAT [5]. In the light of these results, it has been suggested that ABAT has a positive effect on human metabolism, and that triggering BAT activity or increasing the formation of ABAT may be a useful strategy to target obesity, NAFLD, and dyslipidaemia in adults.…”

Section: Introductionmentioning

confidence: 98%

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The role of active brown adipose tissue in human metabolism

Özgüven

Öneş

Yılmaz

et al. 2015

Eur J Nucl Med Mol Imaging

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

The role of active brown adipose tissue in human metabolism

Özgüven

Öneş

Yılmaz

et al. 2015

Eur J Nucl Med Mol Imaging

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“…Insufficient activity of this tissue can play a role in collective pathogenesis of intra-liver triglyceride. In other words, a decrease in brown adipose tissue can increase the risk of NAFLD (48).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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Emerging Concepts on the Pathogenesis of Non‐Alcoholic Steatohepatitis (NASH)

Leclercq

2013

Non‐Alcoholic Fatty Liver Disease

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Association between the presence of brown adipose tissue and non‐alcoholic fatty liver disease in adult humans

Abstract: SUMMARY BackgroundThe presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans.

Cited by 51 publications

References 24 publications

The role of active brown adipose tissue in human metabolism

The role of active brown adipose tissue in human metabolism

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Emerging Concepts on the Pathogenesis of Non‐Alcoholic Steatohepatitis (NASH)

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