Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and In Vitro Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time

Zhao, Xinyang; Zhang, Xu; Wu, Shanshan; Tan, Jichun

doi:10.3389/fendo.2022.862500

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Furthermore, MCLs are associated with the number of retrieved oocytes and clinical pregnancy rate in IVF treatment [15]. According to recent study, clinicians can estimate the range of ovarian stimulation duration by calculating the original length of the follicular phase to obtain more mature oocytes and to optimize clinical outcomes [10]. Benjamins et found that women with AMH >8 ng/mL had follicular phases that were longer by 2 days [16], PCOS patients are always with a higher AMH and longer menstrual cycle length, thus the shorter ovarian stimulation may be detrimental to IVF success rate.…”

Section: Discussionmentioning

confidence: 99%

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Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol

Xiao,

Hong,

Liu

et al. 2024

Preprint

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Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with dysfunctional ovulation affecting female fertility. The purpose of this study was to determine the association between gonadotropin(Gn) duration and in vitro fertilization (IVF) outcomes in PCOS women undergoing GnRH antagonist treatment. Methods: Retrospective cohort study at a large private fertility practice. Patients with PCOS undergoing the GnRH-antagonist treatment between January 1, 2017, and July 31, 2021 were included. Patients were classified into two groups depending on their Gn duration, ≤8 days （ n=501 ） and ＞ 8 days （ n=1326). The primary outcomes measures included the clinical pregnancy, ongoing pregnancy and live birth rate between the two groups after fresh embryo transfer. In addition, the embryo quality was also evaluated. Result(s): There was no significant difference in baseline characteristics between groups. However, the total Gn dosage was lower in PCOS women in the ≤8 days group. In addition, the oocytes retrieved,2PN embryos and D3 high quality embryos were compared between groups. The clinical pregnancy rate, ongoing pregnancy and live birth rate were significantly decreased in the ≤8 days group in fresh embryo transfer（50.00% vs % 66.20%, 45.56% vs 59.08%,40.00% vs 56.49% ). After logistic regression, PCOS women with Gn duration ≤8 days were associated with poor clinical pregnancy，ongoing pregnancy and live birth rate. Conclusion(s): PCOS women with shorter Gn duration(≤8 days) were not associated with impaired embryo outcomes in GnRH antagonist protocol. However, the shorter Gn stimulation was detrimental to clinical pregnancy outcomes in fresh embryo transfer cycle.

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Section: Discussionmentioning

confidence: 99%

“…Recently study has demonstrated that menstrual cycle length (MCL) was associated with ART outcomes [10]. However, it is unclear how stimulation duration affect clinical outcomes in PCOS patients as these patients are always with a longer menstruation and with high ovarian reserve.…”

Section: Introductionmentioning

confidence: 99%

Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol

Xiao,

Hong,

Liu

et al. 2024

Preprint

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“…The duration of ovarian stimulation largely depends on the ovarian response to hormonal stimulation. Age is a critical factor influencing ovarian response in females, so Group 2 had the shortest stimulation duration (10.19 ± 1.73 days, P = 0.008) [ 38 ]. We performed comparisons of the clinical outcomes between the 2 groups.…”

Section: Discussionmentioning

confidence: 99%

Should non-invasive prenatal testing be recommended for patients who achieve pregnancy with PGT?

Liang,

Li,

Fei

et al. 2024

BMC Pregnancy Childbirth

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Objective To determine whether non-invasive prenatal testing is an alternative testing option to preimplantation genetic testing (PGT) in pregnant patients. Methods This was a retrospective study of the clinical outcomes of patients who underwent PGT and invasive or non-invasive pregnancy testing after euploid blastocyst transfer at our IVF centre between January 2017 and December 2022. Results In total, 321 patients were enrolled in this study, 138 (43.0%) received invasive pregnancy testing, and 183 (57.0%) patients underwent non-invasive testing. The mean age of the patients in Group 2 was higher than that of the patients in Group 1 (35.64 ± 4.74 vs. 31.04 ± 4.15 years, P < 0.001). The basal LH and AMH levels were higher in Group 1 than in Group 2 (4.30 ± 2.68 vs. 3.40 ± 1.88, P = 0.003; 5.55 ± 11.22 vs. 4.09 ± 3.55, P = 0.012), but the clinical outcomes were not significantly different. Furthermore, the clinical outcomes of patients undergoing invasive testing were similar to those of patients undergoing non-invasive testing with the same PGT indication. Conclusion Our results suggest that non-invasive pregnancy testing is a suitable alternative option for detecting the foetal chromosomal status in a PGT cycle. However, the usefulness of non-invasive testing in PGT-M patients is still limited.

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A new method of non-ultrasound monitoring of ovarian stimulation (NUMOS): Mission possible!—A pilot study

Vladimirov,

Tacheva,

Gatev

et al. 2024

Global Reproductive Health

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Purpose: This study aims to establish the viability of monitoring an appropriate and safe ovarian stimulation without the use of ultrasound and serum hormone testing. Method: As a primary marker for monitoring the ovarian response, we used urinary estrone-3-glucuronide (E1-3G) growth rate, which was self-measured by patients daily at home, with a portable analyzer, during the stimulation. For an adequate ovarian response, an average daily rate of increase of E1-3G was estimated to be within 25%–77%. Ovulation trigger day was determined based on the length of the menstrual cycle. The study included 24 women. Inclusion criteria were age below 41 years and AMH >1 ng/mL. A progestin-primed ovarian stimulation protocol (PPOS) with fixed doses of gonadotropins was used. Results: The average female age was 32.9 years (±4.4), BMI 22.7 kg/m2 (±4.3), AMH 3.7 ng/mL (±2.6), stimulation days 10.6 (±1.1), collected oocytes 12.5 (±8.5), MII oocytes 10.6 (±7.8), fertilization rate 83.6% (±22.5), blastocyst 66.4% (±28.6), good quality blastocysts 31.6% (±16.9). Absence of oocyte aspiration was found in one of the cases. There were no cases of OHSS and ovarian stimulation cancellation. Conclusions: This is the first pilot study to successfully apply a new marker for ovarian stimulation monitoring.

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Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and In Vitro Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time

Cited by 4 publications

References 48 publications

Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol

Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol

Should non-invasive prenatal testing be recommended for patients who achieve pregnancy with PGT?

A new method of non-ultrasound monitoring of ovarian stimulation (NUMOS): Mission possible!—A pilot study

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