Association between the Risk of Preterm Birth and Low Birth Weight with Periodontal Disease in Pregnant Women: An Umbrella Review

Padilla, Tania; Arbildo-Vega, Heber; Caballero, Luz; Cruzado-Oliva, Fredy; Mamani-Cori, Vilma; Cervantes, Sheyla; Pantoja, Evelyn del Rosario Munayco; Panda, Santosh Kumar; Vásquez-Rodrigo, Hernán; Castro-Mejía, Percy; Huaita-Acha, Delsi

doi:10.3390/dj11030074

Cited by 9 publications

(4 citation statements)

References 47 publications

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“…Regarding the methodological quality, four of five umbrella reviews used AMSTAR-1 (the first version of this tool, published in 2007), whereas only two umbrella reviews [35,37] used AMSTAR-2 as we did. Furthermore, Condylis et al [15] did not assess the methodological quality of the evidence of the included studies at all, which can be considered a serious methodological flaw.…”

Section: Agreement and Disagreement With Previous Umbrella Reviewsmentioning

confidence: 69%

“…To the best of the authors' knowledge, eight umbrella reviews addressed and summarized the available evidence in this association between periodontitis and APOS, and the effect of periodontal disease on pregnancy complications [15][16][17][18][19][35][36][37]. In all eight published umbrella reviews, the authors only analyzed and interpreted the methodological quality and described the main findings of the included systematic reviews on maternal periodontitis and APOs.…”

Section: Agreement and Disagreement With Previous Umbrella Reviewsmentioning

confidence: 99%

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Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality

Machado

Ferreira

Lopes

et al. 2023

JCM

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This umbrella review aims to appraise the methodological quality and strength of evidence on the association between maternal periodontitis and adverse pregnancy outcomes (APOs). PubMed, CENTRAL, Web-of-Science, LILACS, and Clinical Trials were searched until February 2023, without date or language restrictions. Two authors independently screened studies, extracted data, performed the risk-of-bias analysis, and estimated the meta-analytic strengths and validity and the fail-safe number (FSN). A total of 43 SRs were identified, of which 34 conducted meta-analyses. Of the 28 APOs, periodontitis had a strong association with preterm birth (PTB), low birth weight (LBW), and gestational diabetes mellitus (GDM), PTB and LBW showed all levels of strength, and pre-eclampsia showed only suggestive and weak strength. Regarding the consistency of the significant estimates, only 8.7% were likely to change in the future. The impact of periodontal treatment on APOs was examined in 15 SRs, 11 of which conducted meta-analyses. Forty-one meta-analyses were included and showed that periodontal treatment did not have a strong association with APOs, although PTB revealed all levels of strength and LBW showed only suggestive and weak evidence. Strong and highly suggestive evidence from observational studies supports an association of periodontitis with a higher risk of PTB, LBW, GDM, and pre-eclampsia. The effect of periodontal treatment on the prevention of APOs is still uncertain and requires future studies to draw definitive and robust conclusions.

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Section: Agreement and Disagreement With Previous Umbrella Reviewsmentioning

confidence: 69%

Section: Agreement and Disagreement With Previous Umbrella Reviewsmentioning

confidence: 99%

Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality

Machado

Ferreira

Lopes

et al. 2023

JCM

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“…In 1996, Offenbacher was the first to report the association between PD in pregnant women and an increased risk of PB and LBW in babies [93], with this connection being confirmed in several review studies [27,28,30]. This is because hormonal changes during pregnancy, such as elevated levels of estrogen and progesterone, increase vascular permeability in the gums, which facilitates the spread of bacteria and their products, especially anaerobic Gram-negative bacteria, to the fetus [94].…”

Section: Discussionmentioning

confidence: 99%

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Arbildo-Vega,

Padilla-Cáceres,

Caballero-Apaza

et al. 2024

Medicina

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Background: The aim of this review was to evaluate the effects of periodontal disease (PD) treatment in pregnant women to reduce the risk of preterm birth (PB) and low birth weight (LBW) by conducting an umbrella review. Methods: A comprehensive search for the literature up to April 2024 was conducted across multiple databases including PubMed, Cochrane Library, Scopus, EMBASE, Scielo, Web of Science, Google Scholar, Proquest Dissertations and Theses, and OpenGrey. We specifically targeted systematic reviews (SRs) with or without meta-analyses, irrespective of language or time constraints, focusing on primary studies examining the effect of PD treatment in pregnant women to reduce the risk of PB and LBW. Various types of non-systematic reviews, intervention studies, observational studies, preclinical and basic research, summaries, comments, case reports, protocols, personal opinions, letters, and posters were excluded from consideration. The quality and overall confidence of the included studies were assessed using the AMSTAR–2 tool. Results: After the initial search, 232 articles were identified, of which only 24 met the selection criteria after exclusion. The majority of these studies indicated that periodontal treatment reduces the risk of PB and LBW. Conclusions: According to the findings and conclusions drawn from the SRs with a high overall confidence level, PD treatment in pregnant women reduces the risk of PB and LBW.

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“…there is an association between the risk of preterm delivery and low birth weight with periodontal disease and increased oral in ammatory burden in pregnant women [14,15]. Periodontal disease can be controlled with regular dental check-ups and proper oral hygiene at home, using a toothbrush and dental oss at least twice daily; the overall prevalence of oral mucosal disorders is 11.8% in pregnant women.…”

mentioning

confidence: 99%

Knowledge and Habits on Oral Health of Highly Educated Women During Pregnancy and Their Babies. A Cross-sectional Questionnaire Survey in Northern-italy

Cagetti,

Salerno,

Ionescu

et al. 2023

Preprint

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Background: Life-long healthy behaviors are established during pregnancy and the first years of life. This cross-sectional survey aimed to interview new mothers with a high level of schooling living in Northern Italy (Lombardy Region) to assess their knowledge and habits relating to their oral health and their children’s oral health. Methods: A questionnaire (27 items) was developed to assess socio-demographic factors, knowledge, and attitudes toward mothers’ and child’s oral health. The questionnaire was disseminated in perinatal courses, private gynecological clinics, and via social media. Mothers aged ≥ 18 years, with at least a child aged 0-36 months, with a high school diploma or higher, were included in the survey. Results: Overall, 1340 women completed the questionnaire, 1297 of whom had a child aged 0-36 months, 792 were residents in Lombardy, and 600 had a high level of education and were finally included. About half of the sample (44.67%) were between 31 and 35 years, 76.50% were employed, and the majority had only one child (81.50%). During pregnancy, 28.33% of the sample reported problems with teeth and/or gums, while only 36.00% visited a dentist. More than 40% of the sample reported not being aware of a possible correlation between oral health and pregnancy, and 73.17% did not receive advice about their oral health or the future health of the baby’s mouth. Less than 20% of the women was aware of the increased caries risk due to prolonged or nocturnal breastfeeding. Better knowledge/attitude was associated with the age of the child (p<0.01), the number of children (p=0.04), and whether the mother had received advice during pregnancy (p<0.01). Conclusions: The findings of the present survey show a lack of dental care during pregnancy, a lack of information on oral health received from medical personnel during and after pregnancy, and, consequently, gaps in the knowledge needed to care for her and her child’s oral health. There is a need for training courses on oral health for pregnant women and new mothers, but also for a change in the behaviour of health professionals who care for pregnant women.

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Association between the Risk of Preterm Birth and Low Birth Weight with Periodontal Disease in Pregnant Women: An Umbrella Review

Cited by 9 publications

References 47 publications

Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality

Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Knowledge and Habits on Oral Health of Highly Educated Women During Pregnancy and Their Babies. A Cross-sectional Questionnaire Survey in Northern-italy

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