Association between the single-nucleotide polymorphism rs12425791 and ischemic stroke in Chinese populations: new data and meta-analysis

Gu, Lian; Su, Li; Chen, Qing; Xie, Jingui; Yan, Yan; Wu, Guangliang; Tan, Jinjing; Liang, Baoyun; Dou, Weihua; Chen, Wei; Wu, Peng; Wang, Jinping; Tang, Nong

doi:10.3109/00207454.2012.761217

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…In 2012, evidence from meta-analysis revealed that the rs12425791 was significantly associated with the risk of IS under a dominant genetic model [26, 27]. In contrast, an updated meta-analysis carried out in 2013 showed that no significant association between the rs12425791 and IS risk [28]. Similar to the negative data, we found in this study that the rs12425791 did not confer a substantial risk for IS in the Chinese Han population.…”

Section: Discussionsupporting

confidence: 70%

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke

et al. 2019

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Genome-wide association study (GWAS) identified chromosome 12p13 rs12425791 and rs11833579 as susceptibility loci of ischemic stroke (IS) in a European population. However, conflicting results were obtained in subsequent replication analysis. miR-200c, located on chromosome 12p13, was found to have a neuroprotective effect on ischemia. Our aim of this study was to investigate the association of the rs12425791, rs11833579 and rs12904 in the binding site of miR-200c with the risk of IS. The rs12425791, rs11833579, and rs12904 were genotyped using a TaqMan allelic discrimination assay. The results were verified by Sanger sequencing. We found that the rs12904 AG/GG genotypes and G allele were associated with a decreased risk of IS (AG/GG vs. AA: adjusted OR = 0.64; 95% CI, 0.44–0.95; G vs. A: adjusted OR = 0.65; 95% CI, 0.46–0.93). The combined genotypes of the rs11833579AG/AA and rs12904AG/GG were also associated with a reduced risk of IS (OR = 0.65; 95% CI, 0.46–0.93). These findings suggest that the rs12904 may have a jointly protective effect against the risk of IS.

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Section: Discussionsupporting

confidence: 70%

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke

et al. 2019

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“…Previous studies showed that rs12425791 is relative to ischemic stroke risk in Asian population (Lian et al, 2012;Zhang et al, 2016). However, the contradictory studies about association between rs12425791 or NINJ2 gene and ischemic stroke also emerge in Chinese Han population (Chen et al, 2010;Ding et al, 2011;Tong et al, 2011;Wan Gu et al, 2013;Xie et al, 2013). In our study, we found variants rs12425791 of the NINJ2 gene to be strongest associated with ischemic stroke in Chinese Mongolian ethnicity, and A alleles increase the risk of ischemic stroke, indicating the rs12425791 of the NINJ2 gene might play function in the insult of ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China

Wu¹,

Wu²,

Orlov³

et al. 2017

Vestn. VOGiS

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Ишемический инсульт, вызванный прерыванием потока крови в мозг, представляет серьезную медицинскую проблему, являясь фактором риска смерти и потери трудоспособности. Недавние исследования геномных ассоциаций (genome-wide association studies -GWAS) определили более 40 общих вари-антов геномных последовательностей, связанных с ишемиче-ским инсультом. Однако результаты не могут быть одинаково применимы для различных мировых популяций. В данной ра-боте мы рассматриваем гипотезу о том, что население Север-ной Азии, живущее в суровых условиях окружающей среды, может иметь уникальный спектр генов риска развития заболе-ваний сердечно-сосудистой системы. Исследованы гены-кан-дидаты предрасположенности к ишемическому инсульту в по -пуляции монголов Китая, которая не была изучена ранее. В ис-следование были включены в общей сложности 167 больных с инсультом и 176 здоровых лиц. Генотипирование выполне-но с помощью секвенирования ампликонов. Обнаружена ассоциация развития ишемического инсульта с одиночными нуклеотидными полиморфизмами в генах NINJ2 (rs12425791) и ALDH2 (rs2238151), а также в межгенном участке rs9536591. Среди генов-кандидатов наибольший вклад в развитие ин-сульта вносит NINJ2 (rs12425791). Ген ALDH2 кодирует митохон-дриальный фермент альдегиддегидрогеназу, вовлеченную в оксида тивный путь метаболизма алкоголя. Пол, возраст, индекс массы тела и высокое кровяное давление также могут быть факто рами риска. Данная работа показала существующую гетеро генность между китайской и другими популяционными выбор ками. Наше исследование предлагает новый взгляд на взаимо действие генотипа и факторов окружающей среды при развитии ишемического инсульта в монгольском населении.Ключевые слова: популяционная генетика; геном человека; однонуклеотидные замены; монгольская популяция Китая; ишемический инсульт. Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. however, the results are not always the same in populations with different genetic backgrounds. In the present study, we evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions would develop unique genetic risks. We investigated the candidate genes for ischemic stroke and risk factors in a Chinese Mongolian population which has not been explored previously. A total of 167 stroke cases and 176 controls were included in the study. Genotyping was performed by amplicon sequencing. The association was detected with single nucleotide polymorphisms (SNPs) located within genes NINJ2 (rs12425791) and ALDH2 (rs2238151) as well as intergenic rs9536591 were significantly associated with ischemic stroke, of which SNP rs12425791 of the NINJ2 gene was the strongest association. ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, involved in the oxidative pathway of alcohol metabolism. Sex, age, body mass index and high ...

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Impact of chromosome 12p13 variants on ischemic stroke risk

Zhang

Wei

et al. 2015

International Journal of Neuroscience

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Association between the single-nucleotide polymorphism rs12425791 and ischemic stroke in Chinese populations: new data and meta-analysis

Abstract: The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in Chinese populations.

Cited by 3 publications

References 22 publications

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke

Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China

Impact of chromosome 12p13 variants on ischemic stroke risk

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