Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

Abstract

ObjectiveUric acid to high-density lipoprotein cholesterol ratio (UHR), the ratio of uric acid to high-density lipoprotein cholesterol, is a newly proposed marker of metabolic abnormalities. There are few previous studies directly investigating the relationship between UHR and alanine aminotransferase (ALT), especially in short stature populations, however, short stature children and adolescents are more likely to have metabolic disorders. This research aimed to investigate the relationship between the UHR and ALT in children and adolescents with short stature.MethodsIn this cross-sectional analysis, the clinical data of 1,510 children with height below −2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from 1 March 2013 to 31 December 2021, were selected. Anthropometric and biochemical indicators were measured. The relationship between UHR and ALT was analysed.ResultsThe univariate analysis results showed that UHR was positively associated with ALT (β = 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors, a non-linear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β = 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229).ConclusionOur study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.

Association between serum uric acid to high density lipoprotein-cholesterol ratio and arterial stiffness in a Japanese population

“…[19] Additionally, there is emerging evidence suggesting a potential association between UHR and the regulation of ALT levels in Chinese children and adolescents with short stature. [20]…”

“…[19] Additionally, there is emerging evidence suggesting a potential association between UHR and the regulation of ALT levels in Chinese children and adolescents with short stature. [20] UHR is a marker combining UA and HDL-C. Thus, increased UHR is caused by either decreased serum HDL cholesterol, increased serum UA, or both.…”

Uric acid to high-density lipoprotein cholesterol ratio and osteoporosis: evidence from the National Health and Nutrition Examination Survey

“…The uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR), a novel marker indicating metabolic and in ammatory conditions, has been linked to an increased risk of different illnesses in previous research and has been demonstrated to have the ability to serve as a predictor for several clinical outcomes [17][18][19][20]. Xie et al discovered that high UHR levels were independently linked to the risk and severity of nonalcoholic fatty liver disease in the American population, with varying correlations based on gender [20].…”

“…Furthermore, numerous studies have suggested that utilizing these risk factors to identify and predict the likelihood of developing osteoporosis is an e cacious method for early prevention and screening [15, 16]. Therefore, there is a growing emphasis on investigating the factors linked to osteoporosis in current research.The uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR), a novel marker indicating metabolic and in ammatory conditions, has been linked to an increased risk of different illnesses in previous research and has been demonstrated to have the ability to serve as a predictor for several clinical outcomes [17][18][19][20]. Xie et al discovered that high UHR levels were independently linked to the risk and severity of nonalcoholic fatty liver disease in the American population, with varying correlations based on gender [20].…”