Association between the visceral adiposity index and risks of all-cause and cause-specific mortalities in a large cohort: Findings from the UK biobank

He, Qida; Liu, Siyuan; Feng, Zhaolong; Li, Tongxing; Chu, Jiadong; Hu, Wei; Chen, Xuanli; Han, Qiang; Sun, Na; Sun, Hongpeng; Shen, Yueping

doi:10.1016/j.numecd.2022.05.020

Cited by 13 publications

(12 citation statements)

References 42 publications

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“…A large-scale nationwide study from the UK reported that VAI was significantly correlated with an increased risk of all-cause mortality. 49 Although this finding is consistent with our study, a J-shaped link correlation was observed in a sample of elderly Americans with a mean age of 73.4 years. 50 Nevertheless, the latter could not be confidently compared with our results due to the significant differ- Furthermore, we did not find any significant difference between LAP and VAI for CVD incidence, CVD mortality, or all-cause mortality.…”

Section: Discussionsupporting

confidence: 93%

Lipid accumulation product and visceral adiposity index for incidence of cardiovascular diseases and mortality; results from 13 years follow‐up in Isfahan cohort study

Fakhrolmobasheri,

Abhari,

Heidarpour

et al. 2023

Obesity Science & Practice

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Background/AimsVisceral adiposity index (VAI) and lipid accumulation product (LAP) are novel anthropometric indices that have shown an association with metabolic syndrome; however, limited data are available regarding the predictive performance of these indices for the incidence of cardiovascular diseases (CVD) and mortality.MethodsThis study was performed on the data retrieved from Isfahan Cohort Study (ICS). ICS is an ongoing population‐based cohort study conducted in 3 counties in central Iran. Pearson correlation analysis was performed between LAP, VAI, and metabolic parameters. Cox regression analysis and receiver operative characteristics (ROC) curve analysis were performed in order to evaluate the ability of VAI and LAP for the incidence of CVD, CVD‐associated mortality, and all‐cause mortality. We further compared the predictive performance of VAI and LAP with body mass index (BMI).ResultsLAP and VAI were significantly correlated with all metabolic variables, including blood pressure, fasting blood glucose, and lipid profile components. Univariate regression analysis indicated a significant association between LAP and VAI with CVD incidence. In multivariate analysis, only VAI was significantly associated with CVD incidence. Regarding CVD mortality, only VAI in the multivariate analysis revealed a significant association. Interestingly, Both VAI and LAP were negatively associated with all‐cause mortality. ROC curve analysis indicated the superior performance of LAP and VAI for predicting CVD incidence compared to BMI; however, BMI was better in predicting all‐cause mortality.ConclusionCompared to BMI, LAP and VAI are of better predictive performance for the incidence of CVD. In contrast, BMI was superior to VAI and LAP in the prediction of all‐cause mortality.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 93%

Lipid accumulation product and visceral adiposity index for incidence of cardiovascular diseases and mortality; results from 13 years follow‐up in Isfahan cohort study

Fakhrolmobasheri,

Abhari,

Heidarpour

et al. 2023

Obesity Science & Practice

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“… 10 , 11 Notably, direct measurements of VAT are not usually feasible in large epidemiological studies because sophisticated devices are needed, such as dual‐energy X‐ray absorptiometry (DEXA). Some studies (three using devices and two using a prediction model) have measured the associations between VAT mass and mortality, 12 , 13 , 14 , 15 , 16 and the studies that used devices to measure VAT showed inconsistent results. 13 , 14 , 15 Moreover, these studies had some shortcomings, including a relatively short time of follow‐up time, relatively small sample size, specific populations (e.g.…”

Section: Introductionmentioning

confidence: 99%

Age‐specific and sex‐specific associations of visceral adipose tissue mass and fat‐to‐muscle mass ratio with risk of mortality

Sun

et al. 2022

J cachexia sarcopenia muscle

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Background Limited studies have explored the association between visceral adipose tissue (VAT) mass and fat‐to‐muscle mass ratio (FMR) and mortality. We aimed to evaluate the sex‐specific association of VAT and FMR with all‐cause and cause‐specific mortality by age. Methods A total of 438 896 participants (49.8% men, mean age ± standard deviation: 57 ± 8 years for men; 56 ± 8 years for women) were included from the UK Biobank cohort. The nature of VAT was predictive, as obtained by sex‐stratified, non‐linear prediction models. Fat and muscle mass were estimated using a bioelectrical impedance assessment device. FMR was calculated as the fat mass divided by the muscle mass in the whole body. VAT and FMRs were divided into quintiles in ascending order, and the 3rd quintile was used as the reference. Cox regression analyses were used to estimate the associations between VAT, FMR and mortality. Results During a median of 12.4 years of follow‐up, we documented 29 903 deaths. After adjusting for various covariates, the individuals in the highest quintiles of VAT and FMR had the highest hazard ratios (HRs) of all‐cause mortality [1.24 (95% confidence interval: 1.17–1.33) for VAT and 1.24 (1.17–1.31) for FMR in men; and 1.11 (1.03–1.21) for VAT in women], except that the 1st quintile of FMR in women had the greatest HR [1.18 (1.09–1.27)]. Significant interactions were observed in both sexes according to age category (P for interaction < 0.05). Among men <50 years, participants in the 1st and 5th quintiles of VAT and FMR had significantly higher risks of mortality [1.30 (1.02–1.66) and 1.67 (1.27–2.19) in VAT; 1.25 (0.99–1.56) and 1.41 (1.11–1.79) in FMR, respectively]; in women, this phenomenon was observed in the ≥60 age group [1.16 (1.06–1.27) and 1.19 (1.08–1.31) in VAT; 1.18 (1.08–1.29) and 1.11 (1.01–1.22) in FMR, respectively]. VAT showed a linear positive association with mortality in women <60 years and a J‐shaped association from respiratory disease in both sexes ≥60 years. FMR showed a linear positive association with mortality from cancer in men <60 years and a J‐shaped association with mortality from cause‐specific mortality in both sexes ≥60 years, except for mortality from cardiovascular disease in men. Conclusions Most associations of VAT and FMR with all‐cause mortality were J‐shaped and were significantly modified by age status (<50, 50–59 and ≥60 years). The clinical implication is that regarding body composition and VAT mass, different health strategies may be adopted for people of different sexes and ages.

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“…First, we found different associations between CVAI and CVD and cancer mortality. Mounting evidence indicates that visceral adipose tissue (VAT), as measured by machines or calculated by predictive models, is strongly associated with risk of mortality in different populations 18–28 . However, this remains controversial, and little is known about the relationship between visceral fat and mortality in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21][22][23][24][25][26][27][28] However, this remains controversial, and little is known about the relationship between visceral fat and mortality in the Chinese population. Some studies have reported that the presence of greater VAT increases the risk of CVD mortality, 19,27 which was consistent with our findings. Qida et al found that VAI score was significantly correlated with an increased risk of CVD mortality (HR 1.459, 95% CI 1.148-1.255).…”

Section: Discussionmentioning

confidence: 99%

Associations between Chinese visceral adiposity index and risks of all‐cause and cause‐specific mortality: A population‐based cohort study

Wu,

Wang,

et al. 2024

Diabetes Obesity Metabolism

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AimTo determine the associations between the Chinese visceral adiposity index (CVAI) and the risks of all‐cause and cause‐specific mortality.Materials and MethodsA total of 3 916 214 Chinese adults were enrolled in a nationwide population cohort covering all 31 provinces of mainland China. The CVAI was calculated based on age, body mass index, waist circumference, and triglyceride and high‐density lipoprotein cholesterol concentrations. We used a Cox proportional hazards regression model to determine the hazard ratios and 95% confidence intervals (CIs) for risk of mortality associated with different CVAI levels.ResultsThe median follow‐up duration was 3.8 years. A total of 86 158 deaths (34 867 cardiovascular disease [CVD] deaths, 29 884 cancer deaths, and 21 407 deaths due to other causes) were identified. In general, after adjusting for potential confounding factors, a U‐shaped relationship between CVAI and all‐cause mortality was observed by restricted cubic spline (RCS). Compared with participants in CVAI quartile 1, those in CVAI quartile 4 had a 23.0% (95% CI 20.0%–25.0%) lower risk of cancer death, but a 23.0% (95% CI 19.0–27.0) higher risk of CVD death. In subgroup analysis, a J‐shaped and inverted U‐shaped relationship for all‐cause mortality and cancer mortality was observed in the group aged < 60 years.ConclusionsThe CVAI, an accessible indicator reflecting visceral obesity among Chinese adults, has predictive value for all‐cause, CVD, and cancer mortality risks. Moreover, the CVAI carries significance in the field of health economics and secondary prevention. In the future, it could be used for early screening purposes.

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Association between the visceral adiposity index and risks of all-cause and cause-specific mortalities in a large cohort: Findings from the UK biobank

Cited by 13 publications

References 42 publications

Lipid accumulation product and visceral adiposity index for incidence of cardiovascular diseases and mortality; results from 13 years follow‐up in Isfahan cohort study

Lipid accumulation product and visceral adiposity index for incidence of cardiovascular diseases and mortality; results from 13 years follow‐up in Isfahan cohort study

Age‐specific and sex‐specific associations of visceral adipose tissue mass and fat‐to‐muscle mass ratio with risk of mortality

Associations between Chinese visceral adiposity index and risks of all‐cause and cause‐specific mortality: A population‐based cohort study

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