Association between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: a Meta Analysis of 5,193 Cases and 6,645 Controls

Namazi, Abolfazl; Abedinzadeh, Maryam; Nourbaksh, Parisa; Neámatzadeh, Hossein

doi:10.7314/apjcp.2015.16.6.2263

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…Heterogeneity and publication bias are potentially significant problem when interpreting results of a meta-analysis (Jafari-Nedooshan et al, 2017;Namazi et al, 2015;Sadeghiyeh et al, 2017;Yazdi et al, 2017). In this meta-analysis, there was significant between-study heterogeneity for GSTM1 and GSTP1 polymorphisms, which might be due low quality studies such as HWE-violating studies.…”

Section: Discussionmentioning

confidence: 99%

Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis

Moghimi

Sobhan

Jarahzadeh

et al. 2019

Asian Pac J Cancer Prev

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Background:Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma.Methods:Eligible articles were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled using either fixed-effects or random effects models.Results:Finally, a total of 24 case-control studies with 2,405 osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247 95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians.Conclusions:This meta-analysis demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large well-designed epidemiological studies are warranted to validate our results.

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Section: Discussionmentioning

confidence: 99%

Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis

Moghimi

Sobhan

Jarahzadeh

et al. 2019

Asian Pac J Cancer Prev

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“…Thus, one of the most important goals of the meta-analysis is to identify the source of heterogeneity (56) . Basically, between-studies variability and variability due to sampling error are main sources of heterogeneity in a set of studies in a meta-analysis (19,31,55,56) . The between-study heterogeneity in the current meta-analysis existed in overall under all genetic models and subgroup analyses in Asians.…”

Section: Study Namementioning

confidence: 99%

Association of Interleukin-10 -1082 a/G (Rs1800896) Polymorphism With Susceptibility to Gastric Cancer: Meta-Analysis of 6,101 Cases and 8,557 Controls

Namazi

Forat-Yazdi

Jafari

et al. 2018

Arq. Gastroenterol.

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BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.

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“…In addition to mutations in hRAD51 metabolism being linked to Fanconi anemia-like disorders, heritable point mutations in hRAD51D, hRAD51C, hXRCC2, and hXRCC3 have become strongly implicated in non-hBRCA2 associated breast, ovarian, and colorectal cancer families (Blanco et al 2014; Clague et al 2011; Meindl et al 2010; Michalska et al 2015; Namazi et al 2015; Osorio et al 2012; Pelttari et al 2015; Thompson et al 2012). Understanding how these mutant alleles negatively impact hRAD51 paralogue function and protein interactions is essential for both determining how the hRAD51 paralogues normally function and how alterations in their normal biology can lead to cancer development.…”

Section: Links Between Mutations In the Rad51 Regulators Cancer Predmentioning

confidence: 99%

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication

Godin

Sullivan

Bernstein

2016

Biochem. Cell Biol.

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In this review we focus on new insights that challenge our understanding of homologous recombination (HR) and Rad51 regulation. Recent advances using high resolution microscopy and single molecule techniques have broadened our knowledge of Rad51 filament formation and strand invasion at double-strand break (DSB) sites and at replication forks, which are one of most physiologically relevant forms of HR from yeast to humans. Rad51 filament formation and strand invasion is regulated by many mediator proteins such as the Rad51 paralogues and the Shu complex, consisting of a Shu2/SWS1 family member and additional Rad51 paralogues. Importantly, a novel RAD-51 paralogue was discovered in C. elegans and its in vitro characterization has demonstrated a new function for the worm RAD-51 paralogues during HR. Conservation of the human RAD51 paralogues function during HR and repair of replicative damage demonstrate how the RAD51 mediators play a critical role in human health and genomic integrity. Together, these new findings provide a framework for understanding RAD51 and its mediators in DNA repair during multiple cellular contexts.

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Association between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: a Meta Analysis of 5,193 Cases and 6,645 Controls

Cited by 20 publications

References 28 publications

Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis

Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis

Association of Interleukin-10 -1082 a/G (Rs1800896) Polymorphism With Susceptibility to Gastric Cancer: Meta-Analysis of 6,101 Cases and 8,557 Controls

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication

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