Association between thyroid function tests and anti-thyroid peroxidase (TPO) antibodies in pregnancy

Loh, Tze Ping; Tee, John C. S.; Tee, Nancy Wen Sim; Cheng, Wan Ling; Thevarajah, M.; Sabir, Nada; Chew, Yee Yean; Sethi, Sunil; Khoo, Chin Meng

doi:10.1007/s12020-015-0844-y

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…A recent study by Loh et al found that TSH levels were significantly higher (2.0 vs. 1.6 mIU/L, p ¼ 0.04) and TT3 concentrations were significantly lower (1.3 vs. 1.4 pmol/L, p ¼ 0.032) when comparing pregnant women with TPO antibodies to those without TPO antibodies. 37 There was also a trend for FT4, TT4, FT3, and TT3 concentrations to be lower in pregnant women with positive TPO antibodies in the second and third trimesters compared with pregnant women without TPO antibodies. 37 Thus, the authors suggest monitoring of women with positive TPO antibodies in pregnancy for the development of subclinical or overt hypothyroidism.…”

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 90%

“…37 There was also a trend for FT4, TT4, FT3, and TT3 concentrations to be lower in pregnant women with positive TPO antibodies in the second and third trimesters compared with pregnant women without TPO antibodies. 37 Thus, the authors suggest monitoring of women with positive TPO antibodies in pregnancy for the development of subclinical or overt hypothyroidism. 37 Multiple studies have demonstrated an increased risk of miscarriage for women with thyroid autoantibodies.…”

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 90%

“…38 TPO antibodies are found in Hashimoto's thyroiditis and Grave's disease, with prevalence of 90% and 60 to 80%, respectively. 37 These antibodies have also been associated with SCH. A recent study by Loh et al found that TSH levels were significantly higher (2.0 vs. 1.6 mIU/L, p ¼ 0.04) and TT3 concentrations were significantly lower (1.3 vs. 1.4 pmol/L, p ¼ 0.032) when comparing pregnant women with TPO antibodies to those without TPO antibodies.…”

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 99%

“…Anti-TPO antibodies are autoimmune antibodies against a hemoglycoprotein in membranes of thyroid cells. 37 The prevalence of TPO antibodies in the general population is 5.4 to 20%. 38 TPO antibodies are found in Hashimoto's thyroiditis and Grave's disease, with prevalence of 90% and 60 to 80%, respectively.…”

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 99%

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Subclinical Hypothyroidism: Impact on Fertility, Obstetric and Neonatal Outcomes

Usadi

Merriam

2016

Semin Reprod Med

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The incidence of subclinical hypothyroidism (SCH) in pregnancy was classically thought to be low; however, with new definition of normal TSH range in pregnancy, there has been an increase in the percentage of women who meet classification for SCH. The diagnosis of SCH is important not only for monitoring for maternal conversion to overt hypothyroidism, but also for identifying obstetric and neonatal outcomes related to SCH. Although there have been proven associations between maternal overt hypothyroidism and adverse obstetric and neonatal outcomes, there has been conflicting data on the correlation between SCH and these outcomes. Recent data from a meta-analysis found an increased risk of pregnancy loss, placental abruption, premature rupture of membranes, and neonatal death for women with SCH compared to euthyroidism in pregnancy. Research studies have not demonstrated a distinct benefit from treatment of SCH, and the professional societies are divided on their recommendations for treating SCH. Additionally, universal screening of SCH is controversial at present.

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Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 90%

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 90%

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 99%

Section: Thyroid Peroxidase Antibodies and Schmentioning

confidence: 99%

See 2 more Smart Citations

Subclinical Hypothyroidism: Impact on Fertility, Obstetric and Neonatal Outcomes

Usadi

Merriam

2016

Semin Reprod Med

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“…Although the prevalence of thyroid antibody is comparable across ethnic groups (Benhadi et al 2007), there may be differences in sensitivity to TPO antibody depending on race. Additionally, recent reports have indicated that clinically euthyroid pregnant women with TPO antibody have relative hypothyroidism (Loh et al 2016), and that there is a dose dependency of TPO antibody concentration in relation to thyroid function (Korevaar et al 2018). Recently, it has been shown that both low and high TSH levels in early pregnancy affect fetal brain volume (Jansen et al 2019).…”

Section: Discussionmentioning

confidence: 99%

The Presence of Thyroid Peroxidase Antibody Is Associated with Lower Placental Weight in Maternal Thyroid Dysfunction

Ushijima

Furukawa

Sameshima

2019

Tohoku J. Exp. Med.

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Thyroid dysfunction (TD) is caused by thyroid peroxidase (TPO) antibody, as seen in Hashimoto's disease. TD is a common problem of reproductive age and may impair fetal development. Here, we determined the effect of TPO antibody on perinatal outcomes in Japanese women with TD before conception. A retrospective study involving cases of maternal TD with term singleton birth was conducted. The subjects with TD were divided into two groups according to the presence (n = 22) or absence (n = 20) of TPO antibody. The control groups matched for age, parity, and gestational weeks were selected for TPO antibody-positive (n = 44) and -negative TD subjects (n = 40), respectively. Using the standard curve of Japanese placental weight, the frequency of placental weight less than the 50th percentile (small placenta) was examined. Placental weight was lower among TPO antibody-positive TD subjects, compared with TPO antibody-negative TD subjects (p < 0.01). However, other outcomes were similar between the groups. Importantly, compared with control mothers, placental weight was significantly lower (p < 0.01), birth weight tended to be lower (p = 0.07), and the incidence of gestational diabetes mellitus was higher (p = 0.02) among TPO antibody-positive subjects. There was no significant difference in placental weight between TPO antibody-negative subjects and controls. The frequency of small placenta was significantly higher in TPO antibody-positive subjects (odds ratio: 16.7) even when considering diabetes and pregnancy induced hypertension. Thus, the presence of TPO antibody is associated with lower placental weight among Japanese women having TD.

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Immune System

Guan

2021

Clinical Molecular Diagnostics

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Association between thyroid function tests and anti-thyroid peroxidase (TPO) antibodies in pregnancy

Cited by 15 publications

References 9 publications

Subclinical Hypothyroidism: Impact on Fertility, Obstetric and Neonatal Outcomes

Subclinical Hypothyroidism: Impact on Fertility, Obstetric and Neonatal Outcomes

The Presence of Thyroid Peroxidase Antibody Is Associated with Lower Placental Weight in Maternal Thyroid Dysfunction

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