Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Amouzegar, Atieh; Davoodi, Sayed Hossein; Gharibzadeh, Safoora; Mehran, Ladan; Tohidi, Maryam; Azizi, Fereidoun

doi:10.1016/j.diabet.2015.04.004

Cited by 32 publications

(23 citation statements)

References 39 publications

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“…In the current study, abdominal obesity and dyslipidemia were more prevalent in the clinically hypothyroid group and overt hypothyroidism was a significant predictor of MetS, only in men, a gender difference may be due to the fact that most women in this study are under menopausal age (77 %), with mean age of 39.2 ± 13; therefore, the advantageous effects of estrogen in this age group may inhibit progression to MetS in clinically hypothyroid women; in other words, menopause may interact with the effect of thyroid hormones on metabolic abnormalities. A review article reported higher insulin resistance in men compared to women due to greater amounts of visceral and hepatic adipose tissue and lack of the protective effect of estrogen [38], results consistent with those of our previous survey [39]. A review of 30 population based studies in Europe showed a larger casual effect of adiposity on fasting insulin in men, compared to women and sex heterogeneity in the effect of adiposity on CVD risk factors, which could have been a result of differences in adipose endocrine function [40,41].…”

Section: Discussionsupporting

confidence: 90%

Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study

et al. 2017

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The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated. Body weight, waist circumference, and blood pressure were measured. Fasting blood glucose and concentrations of lipids and lipoproteins, free T4, and TSH were assayed. Mean age of the participants was 40.3±14.4 of whom 101 (2%) had overt hypothyroidism, 294 (5%) subclinical hypothyroidism, 82 (2%) overt hyperthyroidism, and 178 (3%) had subclinical hyperthyroidism; 1 704 (32%) had MetS. Clinically hypothyroid subjects had the highest prevalence of MetS (41.6%), abdominal obesity (45%), and hypertriglyceridemia (58%) compared to other groups (p<0.05). Significant odds ratio for prevalent MetS was observed only in clinically hypothyroid men [OR: 2.9, 95% CI: 1.04, 8.4, p=0.04]. In women, the association between overt hypothyroidism and MetS was marginally significant only in the crude model [OR: 0.068, 95% CI (0.97-2.42), p=0.06]. There was higher risk of Mets in subclinically hypothyroid subjects, aged>50. Overt and subclinical hyperthyroidism had significantly higher odds of hyperglycemia in men and women after full adjustment for age, smoking, and BMI. Overt hypothyroidism and subclinical hypothyroidism especially in the elderly could be associated with MetS. Hyperthyroidism may induce hyperglycemia.

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Section: Discussionsupporting

confidence: 90%

Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study

et al. 2017

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“…However, another study found no significant difference in HOMA-IR and BMI values among a population including patients with subclinical hypothyroidism who were classified according to TSH levels [20]. A larger study of 2758 male subjects also suggested a negative association of T4 with insulin resistance in Iranians [21]. We did not see this association in this study, but a larger sample size may be needed.…”

Section: Discussioncontrasting

confidence: 59%

The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

Sun

Chen

Rong-zhen

et al. 2020

Preprint

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Background: This study compared the relationship between thyroid hormones and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus (T2DM) in China. Methods: A total of 64 male patients who were diagnosed as T2DM and 64 non-diabetic males who underwent health examination were matched according to age at a 1:1 ratio. Results: The 32 subjects in each sub-group showed differences in age, body mass index (BMI), mean arterial pressure, waist circumference, visceral fat content, body fat percentage, HbA1c, HOMA-IR, FT3, TSH, HDL-c, adiponectin, leptin, visfatin and TNF-α (all P < 0.05). In the overall population, FT3 was positively correlated with body fat percentage (r=0.21, P=0.02), and negatively correlated with HOMA-IR (r=-0.18, P=0.04) and visfatin (r=-0.47, P <0.01); TSH was positively correlated with body fat percentage (r=0.23, P=0.01). In the T2DM-OB group FT3 was positively correlated with BMI (r=0.45, P <0.05), visceral fat content (r=0.50, P <0.05), and body fat percentage (r=0.44, P <0.05); FT4 was positively correlated with visceral fat content (r=0.38, P <0.05); and TSH was positively correlated with HOMA-IR (r=0.39, P <0.05). Conclusion: TSH increased in obese people and FT3 was lower in patients with T2DM.

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“…Evidence on the link between thyroid autoimmunity and MetS (or its components) is also lacking. Positivity for thyroid antibodies has not been associated with insulin resistance [44] or with MetS and its components, specifically in obesity [45] and in postmenopausal women [46].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

Raposo

Martins

Ferreira

et al. 2019

EMIDDT

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Background The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, the national prevalence of the metabolic syndrome remains high. The association of thyroid pathology with cardiovascular risk has been addressed but is still unclear. Our study aimed to evaluate the prevalence of thyroid dysfunction and autoimmunity and to assess the associations of thyroid-stimulating hormone and thyroid hormones and antibodies with metabolic syndrome, its components, and other possible determinants in a national sample. Material and methods The present study included a subsample of 486 randomly selected participants from a nationwide cross-sectional study sample of 4095 adults. A structured questionnaire was administered on past medical history and socio-demographic and behavioural characteristics. Blood pressure (BP) and anthropometric measurements were collected, and the serum lipid profile, glucose, insulin, hs-CRP, TSH, FT4, FT3 and thyroid antibodies were measured. Results In our sample, the prevalence of hypothyroidism, hyperthyroidism and undiagnosed dysfunction was 4.9%, 2.5% and 72.2%, respectively. Overall, the prevalence of positivity for the thyroid peroxidase and thyroglobulin antibodies was 11.9% and 15.1%, respectively. A positive association was found between free triiodothyronine and metabolic syndrome (OR: 2.019; 95% CI: 1.196, 3.410). Additionally, thyroid peroxidase antibodies had a negative association with metabolic syndrome (OR: 0.465; 95% CI: 0.236, 0.917) and its triglyceride component (OR: 0.321; 95% CI: 0.124, 0.836). Conclusion The prevalence of undiagnosed thyroid dysfunction and autoimmunity was high. Thyroid peroxidase antibodies were negatively associated with metabolic syndrome and its triglyceride component, whereas the free triiodothyronine level was positively associated with metabolic syndrome.

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Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Cited by 32 publications

References 39 publications

Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study

Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study

The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

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