Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

Abstract

ABSTRACT. The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295-8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.

Tumour necrosis factor-α gene -308 G > A and -238 G > A polymorphisms are associated with susceptibility to irritable bowel syndrome and drug efficacy in children

“…Currently, single‐nucleotide polymorphism (SNP) associated with tumour necrosis factor‐α (TNF‐α) that can cause inflammation has been reported to play a role in IBS among the Asian population . TNF‐α gene, a major cytokine, is located at chromosome 6q11.3 with 3 kilobase in length, consisting of four exons and can regulate the response to inflammation . TNF‐α is one of the major stress‐induced pro‐inflammatory cytokines of heart failure, and its sustained expression can contribute to the development of heart failure .…”

“…It has previously been discussed that the alternation of TNF‐α could potentially result in a number of gut biological functions through its impacts on neuronal activity . Moreover, elevated TNF‐α level caused by A alleles at ‐308 G > A and ‐238 G > A may be predisposing factors to certain disease and could worsen the situation in cases such as colorectal cancer . This paper intends to explore the relationship between SNPs in the TNF‐α gene (‐308 G > A and ‐238 G > A) and the disease susceptibility and drug efficacy in IBS.…”

“…5 TNF-α gene, a major cytokine, is located at chromosome 6q11.3 with 3 kilobase in length, consisting of four exons and can regulate the response to inflammation. 6,7 TNF-α is one of the major stress-induced pro-inflammatory cytokines of heart failure, and its sustained expression can contribute to the development of heart failure. 8 In addition, in IBS patients with diarrhoea, it is accompanied with the release of enhanced pro-inflammatory cytokine, including TNF-α.…”

TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A mutation genes in Mexican colorectal cancer patients

“…Colorectal cancer (CRC) is one of the most common diseases in the world and presents a significant public health problem due to its social implications, high healthcare costs, and increasing rates of diagnosis (Pourhoseingholi, 2014;Alberts et al, 2016;Gutiérrez et al, 2016). Approximately 60% of all CRC cases are diagnosed in the developed countries, and its incidence varies between different ethnic groups (Pourhoseingholi, 2014;Siegel et al, 2014;Gutiérrez et al, 2016;Ferlay et al, 2015). In Mexico, CRC is responsible for 4% of all cancer-related mortalities and is considered as one of the major causes of mortality (García et al, 2015).…”

“…CRC is also considered to be a multifactor disease that may result from interactions among genes, proteins and environmental factors. It develops through a gradual accumulation of genetic and epigenetic changes that transform normal colonic mucosa into invasive cancer tissue, while also modifying the chemotherapy response (Alberts et al, 2016;Gutiérrez et al, 2016;Song et al, 2016). Chemotherapy resistance has been associated with factors that can influence the therapeutic potential of a given drug (Tecza et al, 2016).…”