Association between TOP2A, RRM1, HER2, ERCC1 expression and response to chemotherapy in patients with non-muscle invasive bladder cancer

Liu, Zhifei; Xing, Liyong; Zhu, Yanfeng; Shi, Peng; Deng, Gang

doi:10.1016/j.heliyon.2022.e09643

Cited by 2 publications

(2 citation statements)

References 29 publications

(31 reference statements)

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“…In contrast, the knockdown of TOP2A was similarly found to inhibit GBM cell proliferation and invasion and induce apoptosis in primary and recurrent glioma samples [19]. In addition, TOP2A also turned out to be of high biological signi cance in a variety of cancers such as breast and bladder cancers [20,21].…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition

Zhang

Zhou

Wei

et al. 2023

Preprint

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Objective To investigate whether there is an association between immune abnormalities and hepatocellular carcinogenesis in patients with the autoimmune disease systemic lupus erythematosus (SLE), and to explore the possible mechanisms of the association. Methods Based on the mRNA-Seq data of SLE and hepatocellular carcinoma in the public database, we screened the differentially expressed genes using GEO2R, R "Limm" package, and weighted gene co-expression network analysis (WGCNA), respectively, and used random forest tree algorithm to screen out the common genes in both diseases. A random forest(RF) tree algorithm was used to screen out the common genes in the two diseases, to investigate the biological functions of the genes in hepatocellular carcinoma, to construct a nomogram risk prediction model for hepatocellular carcinoma, and to evaluate the predictive efficiency of the model. The immune profile in hepatocellular carcinoma was evaluated based on CIBERSORT and ssGSEA algorithms, and the association of signature genes with the level of tumor immune cell infiltration and the correlation of immune checkpoints in hepatocellular carcinoma were also explored. Results The expression levels of 2 SLE signature genes, CCNB2 and TOP2A, were significantly upregulated in hepatocellular carcinoma, and showed good diagnostic efficacy and clinical prognostic efficacy for hepatocellular carcinoma, suggesting that they may be potential biological targets for hepatocellular carcinoma, and the hepatocellular carcinoma risk prediction model based on the expression levels of CCNB2 and TOP2A showed good risk prediction for hepatocellular carcinoma and has good potential for clinical application. In addition, it was found that the up-regulation of CCNB2 expression may accelerate the G2/M transition of the hepatocellular carcinoma cell cycle, inhibit the apoptotic process, and promote the rate of tumor cell appreciation through the mediation of the p53 signaling pathway, thus contributing to the development and progression of hepatocellular carcinoma. Conclusion The SLE signature genes CCNB2 and TOP2A are potential predictive targets for new-onset hepatocellular carcinoma in SLE patients, and the upregulation of CCNB2 expression may promote hepatocellular carcinoma development and progression through the mediation of the p53 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition

Zhang

Zhou

Wei

et al. 2023

Preprint

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“…Several studies have demonstrated that increased TOP2A expression in glioma cells is strongly associated with tumor metastasis and reduced survival in patients with glioma and that TOP2A is a prominent Wnt pathway activator in glioma, boosting cell growth, motility, and penetration 25 , 39 . Other studies also demonstrated a link between TOP2A and the Wnt signaling pathway 7 , 9 .…”

Section: Discussionmentioning

confidence: 99%

Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer

Wu,

Li,

Zhang

et al. 2024

Sci Rep

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DNA topoisomerase II alpha (TOP2A) expression, gene alterations, and enzyme activity have been studied in various malignant tumors. Abnormal elevation of TOP2A expression is considered to be related to the development of non-small cell lung cancer (NSCLC). However, its association with tumor metastasis and its mode of action remains unclear. Bioinformatics, real-time quantitative PCR, immunohistochemistry and immunoblotting were used to detect TOP2A expression in NSCLC tissues and cells. Cell migration and invasion assays as well as cytoskeletal staining were performed to analyze the effects of TOP2A on the motility, migration and invasion ability of NSCLC cells. Cell cycle and apoptosis assays were used to verify the effects of TOP2A on apoptosis as well as cycle distribution in NSCLC. TOP2A expression was considerably upregulated in NSCLC and significantly correlated with tumor metastasis and the occurrence of epithelial–mesenchymal transition (EMT) in NSCLC. Additionally, by interacting with the classical ligand Wnt3a, TOP2A may trigger the canonical Wnt signaling pathway in NSCLC. These observations suggest that TOP2A promotes EMT in NSCLC by activating the Wnt/β-catenin signaling pathway and positively regulates malignant events in NSCLC, in addition to its significant association with tumor metastasis. TOP2A promotes the metastasis of NSCLC by stimulating the canonical Wnt signaling pathway and inducing EMT. This study further elucidates the mechanism of action of TOP2A, suggesting that it might be a potential therapeutic target for anti-metastatic therapy.

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Association between TOP2A, RRM1, HER2, ERCC1 expression and response to chemotherapy in patients with non-muscle invasive bladder cancer

Cited by 2 publications

References 29 publications

Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition

Systemic lupus erythematosus promotes HCC by promoting cell cycle C2/M transition

Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer

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