Association between trace elements and preeclampsia: A retrospective cohort study

Chen, Ying; Ou, Qi Xin; Chen, Yu; Zhu, Qiao; Tan, Min Hua; Zhang, Miao Miao; Wu, Su Zhen; Xu, Huan

doi:10.1016/j.jtemb.2022.126971

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…21 In 2010, a study reported significant differences in zinc level between pregnant women with preeclampsia and control (8.6 ± 1.4 μmol/L vs 9.4 ± 0.8 μmol/L; p < 0.05). 9 In addition, there were significant differences in zinc level between pregnant women with preeclampsia and control (0.77 ± 0.05 mg/dL versus 0.98 ± 0.03 mg/dL; p = 0.000). 22 In this study, there was lower zinc level compared with other studies.…”

Section: P-value Pe Yes Nomentioning

confidence: 87%

“…Hypertension in pregnancy is used to describe blood pressure disorders in patients who may only experience an increase in mild blood pressure or severe hypertension with some organ dysfunctions including chronic hypertension, gestational hypertension, superimposed preeclampsia, preeclampsia, eclampsia, and hemolytic syndrome in the form of an increase in liver enzymes and a decrease in the number of platelets (HELLP syndrome). 9 Severe preeclampsia criteria is when there are one or more symptoms of systolic blood pressure of more than 160 mmHg and diastolic equal to or more than 110 mmHg, proteinuria more than 2 grams/24 hours or +2. 10 Age has an important influence on the incidence of hypertensive disorder in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Level of maternal zinc serum as risk factor of preeclampsia

Kaprianti¹,

Mirani²,

Martadiansyah³

et al. 2022

Indones J Obstet Gynecol

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Objective : To know the relationship of serum zinc levels with preeclampsia (PE) Method: This observational research uses a type of case control research. The population of this study is all pregnant women with a single pregnancy, gestational age of 28-42 weeks who were treated at the Department of Obstetrics and Gynecology of RSUP Dr. Mohammad Hoesin Palembang from August 2020 to November 2020. The study divided into 2 group, a case group of 30 pregnant women with PE and a control group of 60 pregnant women non PE. Serum zinc level examination is performed on all samples that match the research criteria. The data is processed by using SPSS software program version 20.0 Windows. Result: Both case and control groups had no meaningful differences to the general characteristics of the patient. There were significant differences in average zinc levels of maternal serum in both research groups (p=0.013; 43.90 plus-minus 15.79 pg/dL). The value of serum zinc levels that have the best sensitivity and specificity is at 45.5 pg/dL. Conclusion: There is a meaningful relationship between serum zinc levels and PE events. Pregnant women with serum zinc levels greater than or equal to 45.5 pg /dL were significantly at 3.2 times more risk of PE than pregnant women with serum zinc levels less than or equal to 45.5 pg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia. Keywords: preeclampsia, zinc, case-control studies

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Section: P-value Pe Yes Nomentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Level of maternal zinc serum as risk factor of preeclampsia

Kaprianti¹,

Mirani²,

Martadiansyah³

et al. 2022

Indones J Obstet Gynecol

View full text Add to dashboard Cite

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“…Previous investigations into the impact of metal exposure and its association with preeclampsia primarily relied on human biomonitoring samples, specifically monitoring metal concentrations in maternal blood or urine [ 6 , 7 , 25 , 40 , 41 ]. For example, an analysis conducted by Liu et al utilizing the Boston Birth Cohort found that Mn levels in the red blood cells of pregnant women had a protective effect against the development of preeclampsia; however, no protective effect was found for Se [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another case–control study, conducted in Bangladesh, found significantly lower serum levels of Fe and Zn in preeclampsia patients compared to healthy pregnant women [ 25 ]. Similarly, a retrospective cohort study involving 2186 women in Guangdong, China, reported that elevated levels of blood Mg during mid-term pregnancy were associated with a decreased risk of developing preeclampsia [ 40 ]. Furthermore, a recent meta-analysis comparing Se levels in women with preeclampsia and normotensive controls found a significant correlation between low Se levels and preeclampsia [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study

Hao,

Yu,

et al. 2024

Nutrients

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Preeclampsia is a primary placental disorder, with impaired placental vascularization leading to uteroplacental hypoperfusion. We aimed to investigate differences in metal and metalloid content between the placentas of women with preeclampsia and healthy controls. This was a case–control study in 63 women with preeclampsia and 113 healthy women. Clinical data were obtained from medical records. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure the placental metals and metalloids content. Compared with healthy control subjects, preeclampsia was associated with a significantly lower concentration of essential elements (magnesium, calcium, iron, copper, zinc, and selenium) in the placental tissue. After multivariable adjustment, an interquartile range (IQR) increase in selenium concentration was associated with a reduced risk of preeclampsia with an OR of 0.50 (95% CI: 0.33–0.77). The joint effects of multiple selected metals and metalloids were associated with a reduced risk of preeclampsia. The lower placental magnesium, chromium, iron, zinc, and selenium concentrations of preeclampsia cases indicate a potential link to its pathogenesis. It also provides an intriguing avenue for future research in revealing the underlying mechanisms and potential intervention strategies for preeclampsia.

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“…Hence, Maternal malnutrition can have profound effects on fetal development and pregnancy outcomes, including the occurrence of preterm birth (10,11). Minerals, as important nutrition elements, play a variety of roles in the body, such as construction of bones, cofactor for the enzyme activity, and regulation of blood sugar (8,12). Deficiency in minerals may lead to several consequences, including increased risk of pregnancy complications and perinatal mortality, fetal growth retardation, preterm birth, low birth weight, and infants being small for gestational age (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Association of maternal mineral status with the risk of preterm birth: a retrospective cohort study

Hong,

Jiang,

Lin

et al. 2024

Front. Nutr.

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BackgroundThere has been a gradual increase in the proportion of preterm birth in China during the past several decades. Maternal malnutrition is a significant determinant for preterm birth. Nevertheless, comprehensive studies investigating serum mineral levels during pregnancy associated with preterm birth remain scarce. This study aims to assess the associations between maternal serum mineral levels and the risk of preterm birth.MethodsThis retrospective cohort study of 18,048 pregnant women used data from a tertiary hospital in China from January 2016 to December 2022. Demographic data and serum mineral concentrations in the second and third trimesters of mothers were collected from the hospital information system. Analysis was performed using restricted cubic splines and logistic regression models.ResultsThe proportion of preterm birth in this study was 6.01%. Phosphorus [P for overall = 0.005; P for nonlinear = 0.490; OR (95%CI) = 1.11 (1.04, 1.18)] and chlorine [P for overall = 0.002; P for nonlinear = 0.058; OR (95%CI) = 1.11 (1.03, 1.19)] showed a significant positive correlation with preterm birth in a linear fashion. Furthermore, serum levels of potassium (P for nonlinear <0.001), sodium (P for nonlinear = 0.004), and magnesium (P for nonlinear <0.001) exhibited non-linear relationships with the risk of preterm birth.ConclusionSerum levels of some minerals during pregnancy were associated with the risk of preterm birth among pregnant women. In addition to commonly recognized micronutrients such as folic acid, iron, and vitamin D, healthcare providers should also pay attention to the levels of these minerals during pregnancy.

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Association between trace elements and preeclampsia: A retrospective cohort study

Cited by 10 publications

References 33 publications

Level of maternal zinc serum as risk factor of preeclampsia

Level of maternal zinc serum as risk factor of preeclampsia

Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study

Association of maternal mineral status with the risk of preterm birth: a retrospective cohort study

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