Association between traditional Chinese Medicine and osteoarthritis outcome: A 5-year matched cohort study

Zhou, Qiao; Liu, Jian; Xin, Ling; Fang, Yanyan; Hu, Yuedi; Qi, Yajun; He, Mingyu; Fang, Dahai; Chen, Xiaolu; Cong, Chengzhi

doi:10.1016/j.heliyon.2024.e26289

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e26289

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Association between traditional Chinese Medicine and osteoarthritis outcome: A 5-year matched cohort study

Qiao Zhou,

Jian Liu,

Ling Xin

et al.

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Cited by 2 publications

References 45 publications

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Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway

Zhou,

Liu,

et al. 2025

Journal of Ethnopharmacology

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Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway

Zhou,

Liu,

et al. 2025

Journal of Ethnopharmacology

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Development of Proniosome Gel Formulation for CHIKV Infection

Altay Benetti,

Thwin,

Suhaimi

et al. 2024

Pharmaceutics

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Given the increasing aging population and the rising prevalence of musculoskeletal diseases due to obesity and injury, urgent research is needed to formulate new treatment alternatives, as current options remain inadequate. Viruses can exacerbate arthritis and worsen symptoms in patients with pre-existing osteoarthritis. Over the past decade, the chikungunya virus (CHIKV) has emerged as a significant public health concern, especially in Asia and South America. Exploring natural products, such as berberine, has shown promise due to its anticatabolic, antioxidative, and anti-inflammatory effects. However, berberine’s low stability and bioavailability limit its efficacy. We hypothesized that encapsulating berberine into a proniosome gel, known for its ease of preparation and stability, could enhance its bioavailability and efficacy when applied topically, potentially treating CHIKV infection. Our investigation focused on how varying berberine loads and selected excipients in the proniosome gel influenced its physical properties, stability, and skin permeability. We also examined the biological half-life of berberine in plasma upon topical administration in mice to assess the potential for controlled and sustained drug release. Additionally, we analyzed the antioxidant stress activity and cell viability of HaCaT keratinocytes and developed a lipopolysaccharide-stimulated cell culture model to evaluate anti-inflammatory effects using pro-inflammatory cytokines. Overall, the research aims to transform the treatment landscape for arthritis by leveraging berberine’s therapeutic potential.

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Association between traditional Chinese Medicine and osteoarthritis outcome: A 5-year matched cohort study

Cited by 2 publications

References 45 publications

Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway

Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway

Development of Proniosome Gel Formulation for CHIKV Infection

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