Association between trichlorophenols and neurodegenerative diseases: A cross-sectional study from NHANES 2003–2010

Zhao, Jianhe; Li, Fengquan; Wu, Qihui; Cheng, Yiping; Liang, Guorui; Wang, Xue; Fang, Shuhuan; Wang, Qi; Fan, Xiude; Fang, Jiansong

doi:10.1016/j.chemosphere.2022.135743

Cited by 14 publications

(7 citation statements)

References 51 publications

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“…In the NHANES database, combined with previous literature [ 23 – 25 ], participants with Parkinson’s disease were identified by using “ANTIPAKINSON AGENTS”; this determination was made based on the responses to prescription medication questions. Due to the limitations of medications and codes included in the NHANES, an individual had to be receiving treatment for PD to be classified as having it, and others were identified with non-Parkinson’s disease.…”

Section: Methodsmentioning

confidence: 99%

Dietary Copper Intake and Risk of Parkinson’s Disease: a Cross-sectional Study

Zeng

Cen

Xiong

et al. 2023

Biol Trace Elem Res

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Copper is an essential trace element for the human body. The epidemiological evidence for the association of dietary intake of copper with the risk of Parkinson’s disease (PD) is limited. We conducted an evaluation of the cross-sectional data gathered from the National Health and Nutrition Examination Surveys spanning from 2007 to 2018, which comprised a total of 17,948 participants. To discern the distinct characteristics of the participants, we performed a univariate analysis and utilized a 1:2 ratio propensity score matching method to minimize the effects of selection bias. We employed weighted univariate as well as three multivariate logistic regression models both prior to and following matching, with the aim of examining the association between dietary copper intake and PD risk. Finally, we used the restricted cubic spline (RCS) methodology in order to investigate possible non-linear relationships. Furthermore, subgroup analysis was undertaken to elicit further understanding concerning the association between copper intake and PD. A negative correlation resulted between dietary copper intake and PD risk in both univariate and multivariate logistic regression models, prior to and following matching. Our findings demonstrate that there is a nonlinear, dose-dependent relationship between copper intake and PD, according to our RCS analysis. In subgroup analysis, copper intake was identified as an important protective factor for individuals who were non-Hispanic White, unmarried, and had completed higher education. Dietary copper intake was associated with the risk of PD. Supplementation of dietary copper may have potentially beneficial effects.

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Section: Methodsmentioning

confidence: 99%

Dietary Copper Intake and Risk of Parkinson’s Disease: a Cross-sectional Study

Zeng

Cen

Xiong

et al. 2023

Biol Trace Elem Res

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“…For example, the Canadian Study of Health and Aging, which followed individuals over a period of 10 years, found no significant association between PCB or OCP levels and incident dementia or AD risk; however, elevated levels of PCBs 118, 153, 156, and 163 and OCPs, dichlorodiphenyltrichloroethane and p,p'‐DDE, were significantly associated with lower cognitive performance scores 135 . Work in agricultural sectors also did not confer increased risk for AD in a population with dementia, 132 but a study of trichlorophenol levels in the USA revealed that individuals with higher urinary levels of the agricultural chemical, 2,4,6‐trichlorophenol, had increased risk of AD and of all‐cause mortality 134 . Metals exposure studies, in contrast, support increased AD risk from higher aluminum, cadmium, chromium, copper, and iron 130,136 .…”

Section: The Neural Exposome and Admentioning

confidence: 99%

“…126 Pesticide and metal exposures, as in ALS, have likewise gained interest for their potential association with AD risk, [127][128][129][130][131] but equivocal results for pesticides indicate that additional studies are needed. [132][133][134][135] For example, the Canadian Study of Health and Aging, which followed individuals over a period of 10 years, found no significant association between PCB or OCP levels and incident dementia or AD risk; however, elevated levels of PCBs 118, 153, 156, and 163 and OCPs, dichlorodiphenyltrichloroethane and p,p'-DDE, were significantly associated with lower cognitive performance scores. 135 Work in agricultural sectors also did not confer increased risk for AD in a population with dementia, 132 but a study of trichlorophenol levels in the USA revealed that individuals with higher urinary levels of the agricultural chemical, 2,4,6-trichlorophenol, had increased risk of AD and of all-cause mortality.…”

Section: The Neural Exposome and Admentioning

confidence: 99%

“…135 Work in agricultural sectors also did not confer increased risk for AD in a population with dementia, 132 but a study of trichlorophenol levels in the USA revealed that individuals with higher urinary levels of the agricultural chemical, 2,4,6-trichlorophenol, had increased risk of AD and of all-cause mortality. 134 Metals exposure studies, in contrast, support increased AD risk from higher aluminum, cadmium, chromium, copper, and iron. 130,136 Lead, in particular, is considered neurotoxic and aggravates pathology.…”

Section: The Neural Exposome and Admentioning

confidence: 99%

“…Pesticide and metal exposures, as in ALS, have likewise gained interest for their potential association with AD risk, 127–131 but equivocal results for pesticides indicate that additional studies are needed 132–135 . For example, the Canadian Study of Health and Aging, which followed individuals over a period of 10 years, found no significant association between PCB or OCP levels and incident dementia or AD risk; however, elevated levels of PCBs 118, 153, 156, and 163 and OCPs, dichlorodiphenyltrichloroethane and p,p'‐DDE, were significantly associated with lower cognitive performance scores 135 .…”

Section: The Neural Exposome and Admentioning

confidence: 99%

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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

Sakowski,

Koubek,

Chen

et al. 2024

Annals of Neurology

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Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024

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