Association between Trichomonas vaginalis infection and cervical lesions: a population-based, nested case-control study in Taiwan

Ho, Ling‐Jun; Yang, Hung-Yi; Chung, Chi‐Hsiang; Yang, Sung-Sen; Cheng, Cheng‐Yi; Chien, Wu-Chien; Lin, Hsin‐Chung

doi:10.1007/s00436-020-06759-4

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…As demonstrated in our results, cervical lesions were the most common clinical symptom followed by patchy erythema and vaginal discharge. Similarly, a previous study confirmed that there is a significantly higher risk of developing cervical lesions in women exposed to T. vaginalis compared to those who were not exposed (28).…”

Section: Discussionmentioning

confidence: 52%

Identification of Trichomonas Vaginalis Genotypes Using by Actin Gene and Molecular Based Methods in Southwest of Iran

et al. 2021

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Background:Trichomonas vaginalis (T. vaginalis) is a sexually transmitted protozoan parasite and the causative agent of trichomoniasis. The genetic characterization of T. vaginalis isolates shows notable genetic variation in this parasite. In the present study, we aimed to identify the T. vaginalis genotypes based on analyzing of actin gene in women specimens referred to health centers of Ilam city, southwest Iran. Methods: A total of 1765 female samples were collected from gynecology clinics in the city of Ilam. DNA was extracted from positive samples and nested polymerase chain reaction (Nested PCR) was used to amplify the actin gene. Then, partial sequencing and genotyping of the actin gene was performed. A phylogenetic tree was drawn using the detected genotypes of T. vaginalis and reference sequences. Results: Twenty-one of the 1765 urine and vaginal samples were positive for T. vaginalis. All infected individuals were married and their age in years was between 25 to 34. Further, the majority of infected women had cervical lesions, patchy erythema, and white color discharge. According to sequencing analysis, the isolates were identified as genotype G (n= 8) and genotype E (n= 2). Conclusions: From the collected samples, we were able to distinguish at least two genotypes (G and E) of T. vaginalis. However, lesser is known about these genotypes in the city of Ilam. Further studies with a higher number of isolates should be performed in order to understand the implications of these results in this region.

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Section: Discussionmentioning

confidence: 52%

Identification of Trichomonas Vaginalis Genotypes Using by Actin Gene and Molecular Based Methods in Southwest of Iran

et al. 2021

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“…The studies included in the meta-analysis, published from 1985 to 2021, comprised 67,856 women with cervical neoplasia in different stages and 933,697 healthy controls. Of the 35 studies, 11 were conducted in the Western Pacific [ 24 , 28 , 29 , 47 , 48 , 57 , 59 , 62 – 65 ], 9 in Europe and North America [ 27 , 41 – 44 , 46 , 49 , 51 , 52 ], 7 in South America [ 23 , 26 , 50 , 54 , 55 , 66 , 67 ], 4 in South-East Asia [ 22 , 56 , 58 , 60 ], and 4 in the Middle East and Africa [ 25 , 45 , 53 , 61 ]. All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , …”

Section: Resultsmentioning

confidence: 99%

Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Fazlollahpour-Naghibi

Bagheri

Almukhtar³

et al. 2023

PLoS ONE

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Objectives The evidence in the literature regarding the relationship between Trichomonas vaginalis (TV) infection and cervical neoplasia is conflicting. The main aim of this study was to evaluate the magnitude of the risk of cervical neoplasia associated with TV infection. Methods A meta-analysis of observational studies, which provided raw data on the association of TV infection with cervical neoplasia, was performed. For this aim, we searched scientific databases (PubMed/Medline, Scopus, the Web of Sciences, and Embase) from inception to March 15, 2023. A random-effects model was applied by Stata 17.0 to calculate the pooled and adjusted odds ratios (ORs) with 95% confidence intervals (CI), including subgroup, sensitivity, and cumulative analyses to explore sources of heterogeneity. Results Of the 2584 records initially identified, 35 eligible studies contributed data for 67,856 women with cervical neoplasia, and 933,697 healthy controls from 14 countries were included. The pooled (2.15; 1.61–2.87; I2 = 87.7%) and adjusted (2.17; 1.82–2.60; I2 = 31.27%) ORs indicated a significant positive association between TV infection and the development of cervical neoplasia. There was no significant change in pooled and adjusted ORs by applying sensitivity and cumulative analyses, indicating the robustness of our findings. The pooled OR was significant in most sub-group analyses. There was no publication bias in the included studies. Conclusion Our findings indicated that women with a TV infection are at significantly greater risk of cervical neoplasia. Future research, particularly longitudinal and experimental studies, should be done to better understand the various aspects of this association.

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“…conducted in Korea, trichomoniasis was found in 1.0% of women with ASCUS, 1.0% of women with LSIL, and 0.5% of women with HSIL. The prevalence of trichomoniasis in patients with cervical cancer was discovered to be the lowest in the study by Su et al, 2020 in Taiwan. In this study, trichomoniasis was found in 0.022% of women with cervical lesions.…”

Section: Introductionmentioning

confidence: 88%

“…In this study, trichomoniasis was found in 0.022% of women with cervical lesions. [9][10][11] Based on these data, the prevalence of trichomoniasis in cervical cancer patients ranged from 0.022% to 87.7%. The first factor that influences the difference in prevalence is demographic differences.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Trichomoniasis in Cervical Cancer Patients

Ayuning

Risma

Utami

2022

MHSJ

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Backgroud: Trichomoniasis is the most frequent non-viral sexually transmitted disease in the world, and it can lead to persistent HPV infection. Trichomonas vaginalis infection causes damage to the vaginal mucosa, activation of oncogenes and inactivation of tumor suppressor proteins, and production of non-specific oxidants that lead to cervical cancer. This study aims to determine the prevalence of trichomoniasis in cervical cancer patients. Methods: This study uses systematic literature review method and uses 10 international journals obtained through machine learning and indexed in Scimago. Journals are screened through PRISMA and have gone through a critical appraisal process.This study took place from April to September 2021. Results: The prevalence of trichomoniasis in cervical cancer patients ranged from 0.022% to 87.7%, according to the findings of this study. The prevalence results vary due to differences in demographics and diagnostic methods used. Statistical analysis of the association between trichomoniasis and cervical cancer varied between significant and insignificant. Differences in the association are influenced by the research design used, diagnostic methods, and sample of the research. Conclusions: The conclusion of this study is that the prevalence of trichomoniasis in cervical cancer patients was discovered to be the highest in the study by Ghosh et al. in Kolkata, India (72.6% women with CIN 1, 71.0% women with CIN 2 or CIN 3, and 87.7% women with invasive cancer) and the lowest in the study by Su et al. in Taiwan (0.022%). The association between trichomoniasis and cervical cancer was found to be varied.

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Association between Trichomonas vaginalis infection and cervical lesions: a population-based, nested case-control study in Taiwan

Cited by 9 publications

References 26 publications

Identification of Trichomonas Vaginalis Genotypes Using by Actin Gene and Molecular Based Methods in Southwest of Iran

Identification of Trichomonas Vaginalis Genotypes Using by Actin Gene and Molecular Based Methods in Southwest of Iran

Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Prevalence of Trichomoniasis in Cervical Cancer Patients

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