Association between triglyceride glucose index and risk of cancer: A meta-analysis

Wang, Huan; Yan, F.; Cui, Yani; Chen, Feinan; Wang, Guixia; Cui, Weiwei

doi:10.3389/fendo.2022.1098492

Cited by 14 publications

(11 citation statements)

References 65 publications

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“…It is well known that TyG index has been used as a useful method to detect insulin resistance 14 , and it has recently been reported to be strongly associated with diseases such as diabetes and coronary heart disease 15,16 .Recently, several reports have shown that the TyG Index can predict the risk of many types of cancer 17 .A report analyzing 774 patients with endometrial cancer reported that TyG index was strongly linked to the development and progression of endometrial cancer 18 .A cohort study of 27,944 participants showed that TyG index was strongly associated with the risk of colorectal cancer 13 .Recently,as shown in many epidemiologic and clinical studies, metabolic dysfunction is recognized as a risk factor for poor cancer prognosis 19 .And insulin resistance is considered to be one of the important causes of metabolic dysfunction 20 .Therefore, in order to address this point, we further analyzed the correlation between the TyG index and the three-year prognosis and progression among patients, and concluded that there is a relevance of elevated TyG index to the poor prognosis of colorectal cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and colorectal cancer risk and prognosis - a retrospective study

Wang,

Guo

et al. 2024

Preprint

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OBJECTIVE To verify the correlation of triglyceride-glucose index with the incidence of colorectal cancer and to further determine the correlation of triglyceride-glucose index with the prognosis of colorectal cancer, so as to infer whether the TyG index can be predictive of the incidence and prognosis of colorectal cancer. METHODS This is a retrospective study that evaluated the link with TyG index and the incidence and progression of colorectal cancer. We discussed the connection among TyG index and colorectal cancer risk using logistic regression modeling, respectively, by adjusting for covariates such as gender, age, level of alcohol consumption, and level of smoking. We depicted the ROC curve by analyzing and comparing the size of the area under the curve (AUC) of each risk factor.And we analyzed the correlation between TyG index and pathological stage and three-year prognostic outcome of colorectal cancer patients, respectively. RESULTS Among the 609 participants surveyed, the TyG index was significantly higher in patients with colorectal cancer than in those with normal colorectal function (p < 0.001) ).By adjusting for confounders, the OR for TyG index was 2.001 (95% CI 1.367–2.929, p < 0.001). The area under the curve (AUC) for TyG in the ROC curve analysis was 0.584 (95% CI 0.539–0.629, p < 0.001). Furthermore, the TyG index was correlated and analyzed with three-year prognosis of patients with colorectal cancer, and the OR for TyG was 2.123 (95% CI 1.014–4.445, p = 0.046). CONCLUSION TyG index can be one of the predictors of colorectal cancer incidence. Also TyG index can be one of the indicators to predict poor prognosis of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and colorectal cancer risk and prognosis - a retrospective study

Wang,

Guo

et al. 2024

Preprint

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“…At the same time, MetS, which is closely related to IR, was not identified in 2 meta-analyses as a factor promoting the development of lung cancer [ 83 , 84 ]. However, the triglyceride glucose index (TyG), a more convenient index of IR, was proven to be related to cancer risk (RR = 1.14, 95% CI 1.08–1.20, P < 0.001) [ 85 ]. Our study found a high positive association between IR and lung cancer risk in 463 lung cancer patients out of 1,175 participants.…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Liu,

Wang,

Tan

et al. 2024

Diabetol Metab Syndr

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Background A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. Methods A systematic search was conducted through PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) and Wanfang databases for the corresponding studies. Each study reported the risk estimate and 95% confidence intervals (CI) for lung cancer, and a fixed effects model or random effects model was used for outcome. Results We included 31 publications involving 6,589,383 people with 62,246 cases of lung cancer. Diabetes mellitus (DM) (RR = 1.11, 95% CI 1.06–1.16, P = 0.000) and IR (RR = 2.35, 95% CI 1.55–3.58, P = 0.000) showed a positive association with lung cancer risk. BMI (RR = 0.66, 95% CI 0.54–0.81, P = 0.000) and HDL-C (RR = 0.88, 95% CI 0.79–0.97, P = 0.010) were negatively correlated with lung cancer. MetS(RR = 0.99, 95% CI 0.90–1.09, P = 0.801), TC (RR = 0.93, 95% CI 0.81–1.06, P = 0.274), TG (RR = 0.99, 95% CI 0.88–1.12,P = 0.884), LDL-C (RR = 1.01, 95% CI 0.87–1.16, P = 0.928), hypertension (RR = 1.01, 95% CI 0.88–1.15, P = 0.928), FBG (RR = 1.02, 95% CI 0.92–1.13, P = 0.677) and obesity (RR = 1.11, 95% CI 0.92–1.35, P = 0.280) were not associated with lung cancer. Conclusion Our study showed that the risk of lung cancer is correlated with DM, IR, BMI, and HDL-C. Timely control of these metabolic disorders may have a positive effect on preventing lung cancer. Trial registration Our study has been registered in the Prospective Register of Systematic Reviews (PROSPERO), ID: CRD42023390710.

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“…Diabetes mellitus is a metabolic disorder and has the characteristics of decreased insulin secretion and/or insulin resistance (IR) 1,14 . According to existed researches, IR increases the risk of various types of cancer, such as prostate cancer, 15 non‐small cell lung cancer, 16 gastric cancer, 17 and obesity‐related cancers 18 . And it is also associated with a higher mortality rate 19 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 14 According to existed researches, IR increases the risk of various types of cancer, such as prostate cancer, 15 non‐small cell lung cancer, 16 gastric cancer, 17 and obesity‐related cancers. 18 And it is also associated with a higher mortality rate. 19 However, it remains unclear whether IR is correlated with patients' prognosis for PC patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of glucose‐lipid metabolic index in pancreatic cancer patients with diabetes mellitus

Wang,

Ruan,

et al. 2024

Cancer Medicine

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BackgroundThe incidence of pancreatic cancer (PC) is higher in diabetic patients due to disturbances in glucose and lipid metabolism caused by insulin resistance (IR). However, the effect of diabetes as well as IR on the prognosis of PC patients remains inconclusive. Our study aims to assess the impact of IR on the prognosis of PC patients with diabetes.MethodsWe conducted a retrospective analysis of 172 PC patients with diabetes in our institute from 2015 to 2021. Prognostic assessment was performed using univariate/multifactorial analysis and survival analysis. The predictive efficacy of metabolic indices was compared using receiver operator characteristic (ROC) curve analysis.ResultsOne hundred twenty‐one of 172 patients died during follow‐up, with a median follow‐up of 477 days and a median overall survival (OS) of 270 days. Survival analysis showed a significant difference in OS by IR related parameters, which were triglyceride‐glucose index (TyG), triglyceride‐glucose index‐body mass index (TyG‐BMI), and triglyceride/high‐density lipoprotein cholesterol ratio (TG/HDL‐c). The ROC curve indicated that TyG, TyG‐BMI, and TG/HDL‐c had prognostic efficacy for PC with diabetes. We next optimized TyG‐BMI and obtained a new parameter, namely glucose‐lipid metabolism index (GLMI), and the patients were classified into GLMI low group and high group based on the calculated cutoff value. The GLMI high group had higher TyG, TyG‐BMI, TyG/HDL‐c, BMI, TG, total cholesterol (TC), TC/HDL‐c, fasting plasma glucose, CA199, and more advanced tumor stage compared to low group. Univariate and multivariate analyses showed that GLMI was an independent prognostic factor. Furthermore, the patients of GLMI high group had worse OS compared to low group and the ROC curves showed GLMI had better predictive ability than TyG and TyG‐BMI.ConclusionsIR is associated with the outcome of PC patients with diabetes and higher level of IR indicates worse prognosis. GLMI has a good predictive value for PC with diabetes.

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Association between triglyceride glucose index and risk of cancer: A meta-analysis

Cited by 14 publications

References 65 publications

Triglyceride-glucose index and colorectal cancer risk and prognosis - a retrospective study

Triglyceride-glucose index and colorectal cancer risk and prognosis - a retrospective study

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Prognostic significance of glucose‐lipid metabolic index in pancreatic cancer patients with diabetes mellitus

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