2020
DOI: 10.1186/s12944-020-01403-7
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Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Abstract: Background Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults. Methods This retrospective cohort study was conducted using data from the health… Show more

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Cited by 51 publications
(41 citation statements)
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“…In addition, the levels of TG and LDL-C in the T2DM group were higher than those in the NC group. The free fatty acids produced by TG were able to further reduce insulin sensitivity, forming a vicious circle between TG levels and insulin resistance (14)(15)(16).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the levels of TG and LDL-C in the T2DM group were higher than those in the NC group. The free fatty acids produced by TG were able to further reduce insulin sensitivity, forming a vicious circle between TG levels and insulin resistance (14)(15)(16).…”
Section: Discussionmentioning
confidence: 99%
“…16,17 Clearly, accurate measurement of IR can improve the prediction of T2DM progression. 18 The most common direct method for measuring IR is the hyperinsulinemic-euglycemic clamp, which is complex, impractical, and invasive. 19 The homeostasis model assessment for insulin resistance (HOMA-IR) index is the most widely used indirect method, but is susceptible to the accuracy of insulin measurements and has poor reproducibility.…”
Section: Introductionmentioning
confidence: 99%
“…We performed statistical analysis based on the CDC guidelines ( https://wwwn.cdc.gov/nchs/nhanes/tutorials/default.aspx ). We first dealt with missing data of covariates: for categorical variables (education, physical activity, drinking status and smoking status), missing data were regarded as an independent group 29 . For continuous variables, if missing data were small (< 5%), such as BMI, calcium supplementation, energy and protein intake, then the corresponding mean was used to supplement; and if missing data were large (> 20%), such as 1,25D and PTH, the dummy variables were employed to represent missing values 30 .…”
Section: Methodsmentioning
confidence: 99%